CAGE 1CLT6 - UNIVERSITY OF TEXAS MEDICAL BRANCH
USA

UNIVERSITY OF TEXAS MEDICAL BRANCH

AT GALVESTON

DBA UNIVERSITY OF TEXAS MEDICAL BR

CAGE Code: 1CLT6
DUNS: 800771149
301 UNIVERSITY BLVD
GALVESTON TX 77555-5302
UNITED STATES

Telephone: 409-266-9400
Fax: 409-266-9470

UNIVERSITY OF TEXAS MEDICAL BRANCH, AT GALVESTON, DBA UNIVERSITY OF TEXAS MEDICAL BR is an Active Commercial Supplier with the Cage Code 1CLT6 and is tracked by Dun & Bradstreet under DUNS Number 800771149.

Additional Data For CAGE 1CLT6

SIC Code 1:8071
Status:A
Type:F
Size:E
Primary Business:N
Type of Business:N
Woman Owned:N
CAO:S4402A
ADP CNT CT:HQ0339

USA Government Contracting Activity for 1CLT6

Tuesday, December 19, 2017
$0.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
HIGHLY ENERGETIC HEAVY IONS (HZE), OF THE TYPE FOUND IN GALACTIC COSMIC RAYS, DEPOSIT ENERGY IN CLOSELY SPACED AREAS ALONG THE PATHS (TRACKS) THESE IONS TAKE AS THEY PASS THROUGH CELLS. THIS TIGHT SPACING MAKES THESE PARTICLES PARTICULARLY DAMAGING TO IMPORTANT CELLULAR COMPONENTS SUCH AS CHROMOSOMES. SOME OF THE ENERGY OF THE HZE PARTICLE CAN BE TRANSFERRED TO ELECTRONS (DELTA RAYS) WHICH CAN TRAVEL RELATIVELY LONG DISTANCES AND PRODUCE DAMAGE IN CELLS FAR REMOVED FROM THE ORIGINAL PARTICLE TRACK. THE CELL HAS MECHANISMS THAT CAN REJOIN BROKEN CHROMOSOMES BUT THESE PROCESSES CAN MAKE MISTAKES CAUSING SEGMENTS OF THE CHROMOSOMES INVOLVED TO EXCHANGE. IT IS OUR HYPOTHESIS THAT DAMAGE PRODUCED BY DELTA RAYS FROM HZE PARTICLE TRACKS CAN INTERACT WITH DAMAGE NEAR THE CENTER OF AN INDEPENDENT PARTICLE TRACK AND ADD MORE BREAKS TO AN EXCHANGE THAT MIGHT BE FORMING CLOSE TO THE CENTER OF THE SECOND TRACK. SUCH INTERACTIONS WILL ADD CURVATURE TO THE CHROMOSOME EXCHANGE BREAKPOINT DOSE RESPONSE. WE PLAN TO TEST THIS HYPOTHESIS BY IRRADIATING HUMAN FIBROBLASTS AND LYMPHOCYTES WITH PARTICLES OF DIFFERENT ENERGY CHOSEN IN SUCH A WAY THAT THEY DEPOSIT THE SAME AMOUNT OF ENERGY ALONG A SPECIFIC LENGTH OF THEIR TRACK AND MEASURE THE RESULTING CHROMOSOME EXCHANGES. THE ENERGY IMPARTED TO THE DELTA RAYS WILL BE PROPORTIONAL TO THE ENERGY OF THE HZE PARTICLE SO THAT THE DELTA RAYS FROM A HIGHER ENERGY PARTICLE CAN POTENTIALLY TRAVEL LONGER DISTANCES. THIS SUGGESTS TO US THAT THEY MAY BE ABLE TO ADD MORE BREAKS TO EXCHANGES AND INCREASE THE CURVATURE OF THE DOSE RESPONSE. CHROMOSOME ABERRATIONS ARE IMPORTANT CHANGES IN CELLS THOUGHT TO BE CAUSATIVE OR DIAGNOSTIC OF RADIATION CARCINOGENESIS. A BETTER UNDERSTANDING OF THE MECHANISMS OF THEIR FORMATION WILL REDUCE UNCERTAINTIES IN MODELS USED BY NASA TO DESIGN SPACECRAFT BETTER ABLE TO PROTECT ASTRONAUTS FROM RADIATION.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX14AC76G  
Tuesday, December 19, 2017
$147,278.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
HIGHLY ENERGETIC HEAVY IONS (HZE), OF THE TYPE FOUND IN GALACTIC COSMIC RAYS, DEPOSIT ENERGY IN CLOSELY SPACED AREAS ALONG THE PATHS (TRACKS) THESE IONS TAKE AS THEY PASS THROUGH CELLS. THIS TIGHT SPACING MAKES THESE PARTICLES PARTICULARLY DAMAGING TO IMPORTANT CELLULAR COMPONENTS SUCH AS CHROMOSOMES. SOME OF THE ENERGY OF THE HZE PARTICLE CAN BE TRANSFERRED TO ELECTRONS (DELTA RAYS) WHICH CAN TRAVEL RELATIVELY LONG DISTANCES AND PRODUCE DAMAGE IN CELLS FAR REMOVED FROM THE ORIGINAL PARTICLE TRACK. THE CELL HAS MECHANISMS THAT CAN REJOIN BROKEN CHROMOSOMES BUT THESE PROCESSES CAN MAKE MISTAKES CAUSING SEGMENTS OF THE CHROMOSOMES INVOLVED TO EXCHANGE. IT IS OUR HYPOTHESIS THAT DAMAGE PRODUCED BY DELTA RAYS FROM HZE PARTICLE TRACKS CAN INTERACT WITH DAMAGE NEAR THE CENTER OF AN INDEPENDENT PARTICLE TRACK AND ADD MORE BREAKS TO AN EXCHANGE THAT MIGHT BE FORMING CLOSE TO THE CENTER OF THE SECOND TRACK. SUCH INTERACTIONS WILL ADD CURVATURE TO THE CHROMOSOME EXCHANGE BREAKPOINT DOSE RESPONSE. WE PLAN TO TEST THIS HYPOTHESIS BY IRRADIATING HUMAN FIBROBLASTS AND LYMPHOCYTES WITH PARTICLES OF DIFFERENT ENERGY CHOSEN IN SUCH A WAY THAT THEY DEPOSIT THE SAME AMOUNT OF ENERGY ALONG A SPECIFIC LENGTH OF THEIR TRACK AND MEASURE THE RESULTING CHROMOSOME EXCHANGES. THE ENERGY IMPARTED TO THE DELTA RAYS WILL BE PROPORTIONAL TO THE ENERGY OF THE HZE PARTICLE SO THAT THE DELTA RAYS FROM A HIGHER ENERGY PARTICLE CAN POTENTIALLY TRAVEL LONGER DISTANCES. THIS SUGGESTS TO US THAT THEY MAY BE ABLE TO ADD MORE BREAKS TO EXCHANGES AND INCREASE THE CURVATURE OF THE DOSE RESPONSE. CHROMOSOME ABERRATIONS ARE IMPORTANT CHANGES IN CELLS THOUGHT TO BE CAUSATIVE OR DIAGNOSTIC OF RADIATION CARCINOGENESIS. A BETTER UNDERSTANDING OF THE MECHANISMS OF THEIR FORMATION WILL REDUCE UNCERTAINTIES IN MODELS USED BY NASA TO DESIGN SPACECRAFT BETTER ABLE TO PROTECT ASTRONAUTS FROM RADIATION.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX14AC76G  
Tuesday, December 5, 2017
($27,730.00)
1200: Department of Agriculture
126395: USDA APHIS MRPBS

A: BPA CALL
IGF::OT::IGF UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON WILL TEST CERVID SAMPLES FOR 5 ARBOVIRUSES INCLUDING (1) LACROSSE VIRUS, (2) BLUETONGUE VIRUS, (3) EASTERN EQUINE ENCEPHALITIS,(4) ST. LOUIS ENCEPHALITIS, AND (5) POWASSAN OR DEER TICK VIRUS
Q301: MEDICAL- LABORATORY TESTING

  AG6395K160267     AG6395B160061  
Monday, October 30, 2017
$5,000.00
7500: Department of Health and Human Services
75N980: NATIONAL INSTITUTES OF HEALTH OLAO

C: DELIVERY ORDER
TEST NAICS CODE
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN26300001     HHSN272201700040I     NIHAI2016059  
Friday, October 27, 2017
$417,060.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
1700040I UNIVERSITY OF TEXAS MEDICAL BRANCH; TO A7 VB--17 TASK ORDER FUNDING; BIOD CAN 8470038 $417,060
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200007     HHSN272201700040I     NIHAI2016059  
Thursday, October 26, 2017
$875,449.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
PURPOSE: TO ISSUE TASK A04 BASE TASK ORDER AWARD, "EVALUATION OF THERAPEUTICS AND VACCINES IN MOUSE MODELS OF DENGUE VIRUS"
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200006     HHSN272201700040I     NIHAI2016059  
Thursday, October 19, 2017
$2,909.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
1700040I UNIVERSITY OF TEXAS MEDICAL BRANCH; TO B1 OBRA--13 BASE IDIQ CONTRACT KICK-OFF BASE FUNDING; BIOD CAN 8470038 $2,909
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200004     HHSN272201700040I     NIHAI2016059  
Thursday, October 19, 2017
$1,455.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
1700040I UNIVERSITY OF TEXAS MEDICAL BRANCH; TO C1 OBRA--8 BASE IDIQ CONTRACT KICK-OFF BASE FUNDING; BIOD CAN 8470038 $1,455
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200005     HHSN272201700040I     NIHAI2016059  
Wednesday, September 27, 2017
($78,935.20)
7500: Department of Health and Human Services
75A501: OFFICE OF ACQ MGMT POLICY

C: DELIVERY ORDER
IGF::OT::IGF ANIMAL MODEL DEVELOPMENT AND TECHNICAL REPORTS ON TASK ORDERS
AN13: R&D- MEDICAL: BIOMEDICAL (ADVANCED DEVELOPMENT)

  HHSO10033001T     HHSO100201100015I     10100SOL00025  
Monday, September 25, 2017
$57,475.46
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

F: COOPERATIVE AGREEMENT
THE TRAINING REQUIREMENTS FOR SPACE MEDICINE OPERATIONAL AND RESEARCH PROVIDERS ARE UNIQUE. AS PARTNERS IN THIS SPACE MEDICINE FOCUSED RESIDENCY PROGRAM, NASA AND THE UNIVERSITY OF TEXAS MEDICAL BRANCH (UTMB) HAVE A 21-YEAR TRACK RECORD OF SUCCESSFULLY SELECTING AND TRAINING OUTSTANDING PHYSICIANS WHO PROGRESS TO ACTIVELY SUPPORT NASA AND MEET NEEDS OF THE U.S. SPACE PROGRAM. NOT ONLY ARE THE RESIDENTS TRAINED FOR SPACE MEDICINE SUPPORT AT NASA, THEY ALSO COMPLETE THE CORE COMPETENCIES SET BY THE ACCREDITATION COUNCIL ON GRADUATE MEDICAL EDUCATION (ACGME), LEADING TO CERTIFICATION IN AEROSPACE MEDICINE BY THE AMERICAN BOARD OF PREVENTIVE MEDICINE. UTMB OFFERS GRADUATE COURSES AS PART OF THE APPROVED MASTER OF PUBLIC HEALTH (MPH) WITH AN AEROSPACE MEDICINE TRACK AND PRACTICUM ACTIVITIES. OTHER EDUCATIONAL ACTIVITIES, SUCH AS JOURNAL CLUB AND AEROSPACE GRAND ROUNDS ARE ESSENTIAL TO SPACE MEDICINE PRACTITIONERS, AND ARE AVAILABLE LOCALLY AND REMOTELY FOR PHYSICIANS AT ALL THE NASA CENTERS, SATELLITE LOCATIONS, AND STREAMED LIVE. THIS ALLOWS PRACTICING PHYSICIANS TO TAKE ADVANTAGE OF OPPORTUNITIES TO IMPROVE THEIR CLINICAL AND ACADEMIC SKILLS AND MEET THE CONTINUING MEDICAL EDUCATION (CME) REQUIREMENTS OF STATE LICENSING BOARDS. UTMB ALSO COORDINATES OTHER ACTIVITIES FOR NASA PHYSICIANS AND RESIDENTS, SUCH AS VOLUNTEER SERVICE PROJECTS, PROVIDING MEDICAL SUPPORT FOR THE WINGS OVER HOUSTON AIRSHOW AND THE HOUSTON MARATHON, CME TRAINING SUCH AS ADVANCED CARDIAC LIFE SUPPORT, BASIC LIFE SUPPORT, AND PRE-HOSPITAL TRAUMA LIFE SUPPORT TRAINING, AS WELL AS OPPORTUNITIES FOR ADJUNCT FACULTY APPOINTMENTS, MEDICAL CREDENTIALING, AND TEACHING. NO OTHER ACADEMIC INSTITUTION PROVIDES ACADEMIC AND PRACTICUM ACTIVITIES SO CLOSELY TIED TO MEDICAL OPERATIONS AND SCIENCE SUPPORT IN THE SPACE PROGRAM. UTMB ALSO MAINTAINS AFFILIATION AGREEMENTS WITH MILITARY AND FEDERAL AVIATION-RELATED INSTITUTIONS SUCH AS THE USAF SCHOOL OF AEROSPACE MEDICINE, WRIGHT-PATTERSON AIR FORCE BASE, THE US ARMY SCHOOL OF AVIATION MEDICINE, AND THE FAA CIVIL AEROSPACE MEDICAL INSTITUTE THAT BENEFIT NOT ONLY NASA BUT THE MILITARY AND CIVILIAN CREWMEMBERS THESE PHYSICIANS EVENTUALLY SUPPORT. RESIDENT PHYSICIANS SUPPORTED BY THIS AGREEMENT ARE TRAINED IN ALL ASPECTS OF AEROSPACE MEDICINE, AND UPON GRADUATION ARE ABLE TO FUNCTION IN ENVIRONMENTS AS DIVERSE AS GENERAL AVIATION, COMMERCIAL AVIATION, SPACE FLIGHT, AND IN GOVERNMENTAL AND ACADEMIC INSTITUTIONS. IN PREPARATION FOR FUTURE INCREASED COOPERATION WITH THE COMMERCIAL SPACEFLIGHT INDUSTRY, RESIDENTS ARE GIVEN EXPERIENCE IN THIS ARENA AS WELL. GRADUATES OF THE AEROSPACE MEDICINE RESIDENCY PROGRAM ARE IN DEMAND, AND IT IS PREDICTED THAT THIS DEMAND WILL CONTINUE THROUGH THE LIFE CYCLE OF THE ISS AND ON TO FUTURE EXPLORATION MISSIONS. TO DATE, 30 OF THE 40 PROGRAM'S GRADUATES HAVE BEEN EMPLOYED BY NASA OR ONE OF ITS PRIMARY CONTRACTORS. THE TRAINING PARTNERSHIP PRODUCES GRADUATES THAT ARE IMMEDIATELY PRODUCTIVE WHEN HIRED. NASA AND UTMB HAVE A UNIQUE OPPORTUNITY TO CONTINUE THIS PRODUCTIVE PARTNERSHIP IN TRAINING THE NEXT GENERATION OF SPACE MEDICINE PHYSICIANS TO LEAD THE FIELD IN RESEARCH AND OPERATIONAL SUPPORT. UTMB PROPOSES TO CONTINUE PRODUCING GRADUATES TRAINED AND BOARD ELIGIBLE IN AEROSPACE MEDICINE, WITH AN EMPHASIS IN SPACE. UTMB IS REQUESTING NASA'S CONTINUED FINANCIAL SUPPORT FOR GRADUATE MEDICAL EDUCATION TRAINING IN AEROSPACE MEDICINE. IN ORDER TO FACILITATE LONG TERM PLANNING, UTMB IS SEEKING A NEW FIVE YEAR COOPERATIVE AGREEMENT.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX16AC91A  
Friday, September 15, 2017
$7,500.00
9700: Department of Defense
W91ZLK: W6QK ACC-APG DIR

B: PURCHASE ORDER
IGF::OT::IGF TRAINING - BIO SAFETY
U099: EDUCATION/TRAINING- OTHER

  W91ZLK17P0200     W91ZLK17T0224  
Thursday, September 7, 2017
$627,668.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
IGF::OT::IGF PURPOSE: TO OBLIGATE BASE PERIOD FOR TASK A02 TO THE UNIVERSITY OF TEXAS MEDICAL BRANCH.
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200001     HHSN272201700040I     NIHAI2016059  
Tuesday, August 22, 2017
$110,789.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
HIGHLY ENERGETIC HEAVY IONS (HZE), OF THE TYPE FOUND IN GALACTIC COSMIC RAYS, DEPOSIT ENERGY IN CLOSELY SPACED AREAS ALONG THE PATHS (TRACKS) THESE IONS TAKE AS THEY PASS THROUGH CELLS. THIS TIGHT SPACING MAKES THESE PARTICLES PARTICULARLY DAMAGING TO IMPORTANT CELLULAR COMPONENTS SUCH AS CHROMOSOMES. SOME OF THE ENERGY OF THE HZE PARTICLE CAN BE TRANSFERRED TO ELECTRONS (DELTA RAYS) WHICH CAN TRAVEL RELATIVELY LONG DISTANCES AND PRODUCE DAMAGE IN CELLS FAR REMOVED FROM THE ORIGINAL PARTICLE TRACK. THE CELL HAS MECHANISMS THAT CAN REJOIN BROKEN CHROMOSOMES BUT THESE PROCESSES CAN MAKE MISTAKES CAUSING SEGMENTS OF THE CHROMOSOMES INVOLVED TO EXCHANGE. IT IS OUR HYPOTHESIS THAT DAMAGE PRODUCED BY DELTA RAYS FROM HZE PARTICLE TRACKS CAN INTERACT WITH DAMAGE NEAR THE CENTER OF AN INDEPENDENT PARTICLE TRACK AND ADD MORE BREAKS TO AN EXCHANGE THAT MIGHT BE FORMING CLOSE TO THE CENTER OF THE SECOND TRACK. SUCH INTERACTIONS WILL ADD CURVATURE TO THE CHROMOSOME EXCHANGE BREAKPOINT DOSE RESPONSE. WE PLAN TO TEST THIS HYPOTHESIS BY IRRADIATING HUMAN FIBROBLASTS AND LYMPHOCYTES WITH PARTICLES OF DIFFERENT ENERGY CHOSEN IN SUCH A WAY THAT THEY DEPOSIT THE SAME AMOUNT OF ENERGY ALONG A SPECIFIC LENGTH OF THEIR TRACK AND MEASURE THE RESULTING CHROMOSOME EXCHANGES. THE ENERGY IMPARTED TO THE DELTA RAYS WILL BE PROPORTIONAL TO THE ENERGY OF THE HZE PARTICLE SO THAT THE DELTA RAYS FROM A HIGHER ENERGY PARTICLE CAN POTENTIALLY TRAVEL LONGER DISTANCES. THIS SUGGESTS TO US THAT THEY MAY BE ABLE TO ADD MORE BREAKS TO EXCHANGES AND INCREASE THE CURVATURE OF THE DOSE RESPONSE. CHROMOSOME ABERRATIONS ARE IMPORTANT CHANGES IN CELLS THOUGHT TO BE CAUSATIVE OR DIAGNOSTIC OF RADIATION CARCINOGENESIS. A BETTER UNDERSTANDING OF THE MECHANISMS OF THEIR FORMATION WILL REDUCE UNCERTAINTIES IN MODELS USED BY NASA TO DESIGN SPACECRAFT BETTER ABLE TO PROTECT ASTRONAUTS FROM RADIATION.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX14AC76G  
Thursday, August 17, 2017
$199,316.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
DURING DEEP SPACE EXPLORATION, PERSONNEL WILL BE EXPOSED TO LOW-FLUENCES OF DENSELY-IONIZING CHARGED PARTICLES OF INTERMEDIATE AND HIGH ATOMIC NUMBER. FOR A GIVEN DOSE THESE ARE ALMOST CERTAINLY MORE LIKELY TO CAUSE CANCER THAN THE SPARSELY IONIZING TYPES OF RADIATION TYPICALLY ENCOUNTERED ON EARTH, SUCH AS X- AND GAMMA-RAYS. IT IS NOT POSSIBLE TO DETERMINE THE CARCINOGENIC POTENTIAL OF SUCH RADIATIONS DIRECTLY IN ASTRONAUTS, SO IT BECOMES NECESSARY TO RELY ON SURROGATE EXPERIMENTAL SYSTEMS TO PROVIDE THIS INFORMATION. BECAUSE THEY CAUSE CANCER, BECAUSE THEY FOUND IN VIRTUALLY ALL CANCERS, AND BECAUSE THEY RESPOND TO DOSE IN BIOPHYSICALLY PREDICTABLE WAYS, THE FORMATION NONLETHAL (TRANSMISSIBLE) CHROMOSOME ABERRATIONS REPRESENTS AN EXCELLENT SURROGATE MODEL TO STUDY RADIATION CARCINOGENESIS. AND YET, ONLY RECENTLY HAVE WE BEGUN TO REALLY UNDERSTAND THE MOLECULAR PROCESSES GOVERNING ABERRATION FORMATION, INCLUDING DIFFERENCES THAT PROBABLY EXIST IN THE WAY THAT THEY ARE PRODUCED BY SPARSELY- VERSUS DENSELY-IONIZING RADIATIONS. WE PROPOSE USING WHOLE GENOME SEQUENCING TO CHARACTERIZE STRUCTURAL CHANGES TO THE DNA OF NORMAL HUMAN CELLS THAT ACCOMPANY THE FORMATION OF TRANSMISSIBLE CHROMOSOME ABERRATIONS. WE FOCUS OUR STUDY ON PORTIONS OF THE GCR SPECTRA THAT ARE LIKELY TO BE ENCOUNTERED IN DEEP SPACE, AND WHICH WE HYPOTHESIZE WILL ELICIT DIFFERENT BIOLOGICAL RESPONSES AT THE DNA LEVEL.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX15AG74G  
Thursday, August 17, 2017
$24,824.04
3600: Department of Veterans Affairs
36C24E: SAO EAST (00240E)

D: DEFINITIVE CONTRACT
IGF::OT::IGF MICE BREEDING
AJ92: R&D- GENERAL SCIENCE/TECHNOLOGY: OTHER (APPLIED RESEARCH/EXPLORATORY DEVELOPMENT)

  VA26815C0041     VA268-15-Q-0106  
Wednesday, August 16, 2017
$200,000.00
9700: Department of Defense
HDTRA1: DEFENSE THREAT REDUCTION AGENCY

D: DEFINITIVE CONTRACT
IGF::OT::IGF INCREMENTAL FUNDING
AD92: R&D- DEFENSE OTHER: OTHER (APPLIED RESEARCH/EXPLORATORY DEVELOPMENT)

  HDTRA117C0015  
Tuesday, August 8, 2017
$17,186.00
9700: Department of Defense
N0622A: NAVY MEDICINE PROFESSIONAL

C: DELIVERY ORDER
IGF::OT::IGF TUITION AND FEES
U005: EDUCATION/TRAINING- TUITION/REGISTRATION/MEMBERSHIP FEES

  N0622A17F00XA     N0014098G2541  
Friday, August 4, 2017
$17,186.00
9700: Department of Defense
N0622A: NAVY MEDICINE PROFESSIONAL

C: DELIVERY ORDER
IGF::OT::IGF TUITION AND FEES
U005: EDUCATION/TRAINING- TUITION/REGISTRATION/MEMBERSHIP FEES

  N0622A17F00XA     N0014098G2541  
Wednesday, August 2, 2017
$165,632.86
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

F: COOPERATIVE AGREEMENT
THE TRAINING REQUIREMENTS FOR SPACE MEDICINE OPERATIONAL AND RESEARCH PROVIDERS ARE UNIQUE. AS PARTNERS IN THIS SPACE MEDICINE FOCUSED RESIDENCY PROGRAM, NASA AND THE UNIVERSITY OF TEXAS MEDICAL BRANCH (UTMB) HAVE A 21-YEAR TRACK RECORD OF SUCCESSFULLY SELECTING AND TRAINING OUTSTANDING PHYSICIANS WHO PROGRESS TO ACTIVELY SUPPORT NASA AND MEET NEEDS OF THE U.S. SPACE PROGRAM. NOT ONLY ARE THE RESIDENTS TRAINED FOR SPACE MEDICINE SUPPORT AT NASA, THEY ALSO COMPLETE THE CORE COMPETENCIES SET BY THE ACCREDITATION COUNCIL ON GRADUATE MEDICAL EDUCATION (ACGME), LEADING TO CERTIFICATION IN AEROSPACE MEDICINE BY THE AMERICAN BOARD OF PREVENTIVE MEDICINE. UTMB OFFERS GRADUATE COURSES AS PART OF THE APPROVED MASTER OF PUBLIC HEALTH (MPH) WITH AN AEROSPACE MEDICINE TRACK AND PRACTICUM ACTIVITIES. OTHER EDUCATIONAL ACTIVITIES, SUCH AS JOURNAL CLUB AND AEROSPACE GRAND ROUNDS ARE ESSENTIAL TO SPACE MEDICINE PRACTITIONERS, AND ARE AVAILABLE LOCALLY AND REMOTELY FOR PHYSICIANS AT ALL THE NASA CENTERS, SATELLITE LOCATIONS, AND STREAMED LIVE. THIS ALLOWS PRACTICING PHYSICIANS TO TAKE ADVANTAGE OF OPPORTUNITIES TO IMPROVE THEIR CLINICAL AND ACADEMIC SKILLS AND MEET THE CONTINUING MEDICAL EDUCATION (CME) REQUIREMENTS OF STATE LICENSING BOARDS. UTMB ALSO COORDINATES OTHER ACTIVITIES FOR NASA PHYSICIANS AND RESIDENTS, SUCH AS VOLUNTEER SERVICE PROJECTS, PROVIDING MEDICAL SUPPORT FOR THE WINGS OVER HOUSTON AIRSHOW AND THE HOUSTON MARATHON, CME TRAINING SUCH AS ADVANCED CARDIAC LIFE SUPPORT, BASIC LIFE SUPPORT, AND PRE-HOSPITAL TRAUMA LIFE SUPPORT TRAINING, AS WELL AS OPPORTUNITIES FOR ADJUNCT FACULTY APPOINTMENTS, MEDICAL CREDENTIALING, AND TEACHING. NO OTHER ACADEMIC INSTITUTION PROVIDES ACADEMIC AND PRACTICUM ACTIVITIES SO CLOSELY TIED TO MEDICAL OPERATIONS AND SCIENCE SUPPORT IN THE SPACE PROGRAM. UTMB ALSO MAINTAINS AFFILIATION AGREEMENTS WITH MILITARY AND FEDERAL AVIATION-RELATED INSTITUTIONS SUCH AS THE USAF SCHOOL OF AEROSPACE MEDICINE, WRIGHT-PATTERSON AIR FORCE BASE, THE US ARMY SCHOOL OF AVIATION MEDICINE, AND THE FAA CIVIL AEROSPACE MEDICAL INSTITUTE THAT BENEFIT NOT ONLY NASA BUT THE MILITARY AND CIVILIAN CREWMEMBERS THESE PHYSICIANS EVENTUALLY SUPPORT. RESIDENT PHYSICIANS SUPPORTED BY THIS AGREEMENT ARE TRAINED IN ALL ASPECTS OF AEROSPACE MEDICINE, AND UPON GRADUATION ARE ABLE TO FUNCTION IN ENVIRONMENTS AS DIVERSE AS GENERAL AVIATION, COMMERCIAL AVIATION, SPACE FLIGHT, AND IN GOVERNMENTAL AND ACADEMIC INSTITUTIONS. IN PREPARATION FOR FUTURE INCREASED COOPERATION WITH THE COMMERCIAL SPACEFLIGHT INDUSTRY, RESIDENTS ARE GIVEN EXPERIENCE IN THIS ARENA AS WELL. GRADUATES OF THE AEROSPACE MEDICINE RESIDENCY PROGRAM ARE IN DEMAND, AND IT IS PREDICTED THAT THIS DEMAND WILL CONTINUE THROUGH THE LIFE CYCLE OF THE ISS AND ON TO FUTURE EXPLORATION MISSIONS. TO DATE, 30 OF THE 40 PROGRAM'S GRADUATES HAVE BEEN EMPLOYED BY NASA OR ONE OF ITS PRIMARY CONTRACTORS. THE TRAINING PARTNERSHIP PRODUCES GRADUATES THAT ARE IMMEDIATELY PRODUCTIVE WHEN HIRED. NASA AND UTMB HAVE A UNIQUE OPPORTUNITY TO CONTINUE THIS PRODUCTIVE PARTNERSHIP IN TRAINING THE NEXT GENERATION OF SPACE MEDICINE PHYSICIANS TO LEAD THE FIELD IN RESEARCH AND OPERATIONAL SUPPORT. UTMB PROPOSES TO CONTINUE PRODUCING GRADUATES TRAINED AND BOARD ELIGIBLE IN AEROSPACE MEDICINE, WITH AN EMPHASIS IN SPACE. UTMB IS REQUESTING NASA'S CONTINUED FINANCIAL SUPPORT FOR GRADUATE MEDICAL EDUCATION TRAINING IN AEROSPACE MEDICINE. IN ORDER TO FACILITATE LONG TERM PLANNING, UTMB IS SEEKING A NEW FIVE YEAR COOPERATIVE AGREEMENT.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX16AC91A  
Tuesday, July 25, 2017
($139.30)
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
THE LONG-TERM GOAL OF THIS PROPOSAL IS TO DETERMINE THE THERAPEUTIC EFFICACY OF TESTOSTERONE AND LEUCINE AT PRESERVING LEAN MUSCLE MASS, MUSCLE STRENGTH, AND BONE MINERAL DENSITY IN HEALTHY HUMANS DURING SPACEFLIGHT. WE PROPOSE TO EXAMINE THE INTERACTIVE OR ADDITIVE EFFECTS OF THE COMBINATION OFTESTOSTERONE OR LEUCINE AND EXERCISE ON LEAN BODY MASS (LBM), MUSCLE STRENGTH AND BONE HEALTH. OUR GENERAL HYPOTHESIS IS THAT THE MAINTENANCE OF NORMAL PHYSIOLOGIC LEVELS OF TESTOSTERONE IN MALES OR INCREASING LEUCINE AVAILABILITY IN FEMALES DURING SPACEFLIGHT WILL PROTECT AGAINST THE FUNCTIONAL LOSS OF MUSCLE AND BONE, AND WILL MAXIMIZE THE EFFICACY OF EXISTING RESISTANCE EXERCISE PROTOCOLS AT PREVENTING OR REVERSING FUNCTIONAL IMPAIRMENTS THAT OCCUR DURING 3 MONTHS OF BED REST IN BOTH MEN AND WOMEN. TO ACHIEVE THESE GOALS WE WILL TEST THE FOLLOWING SPECIFIC HYPOTHESES BEFORE, DURING AND AFTER 90 DAYS OF BED REST: 1) MONTHLY CYCLED TESTOSTERONE REPLACEMENT (DAILY TESTOSTERONE FOR 1ST MONTH, FOLLOWED BY ONE MONTH OFF, ETC.) IN CONJUNCTION WITH EXERCISE WILL HAVE AN ADDITIVE EFFECT IN PREVENTING LOSS OF MUSCLE MASS, MUSCLE STRENGTH, BONE MASS, AND MARKERS OF BONE METABOLISM IN MEN REPRESENTATIVE OFTHE ASTRONAUT POPULATION COMPARED TO EXERCISE WITH PLACEBO TESTOSTERONE. 2) DAILY LEUCINE SUPPLEMENTATION (3 X 4G TAKEN WITH MEALS) IN CONJUNCTION WITH EXERCISE WILL HAVE AN ADDITIVE EFFECT IN PREVENTING LOSS OF MUSCLE MASS AND MUSCLE STRENGTH IN WOMEN REPRESENTATIVE OF THE ASTRONAUT POPULATION COMPARED TO EXERCISE WITH PLACEBO LEUCINE. TO ADDRESS THESE HYPOTHESES WE WILL INVESTIGATE THE FOLLOWING SPECIFIC AIMS BEFORE, DURING AND AFTER 90 DAYS OF BED REST: SPECIFIC AIM LA: TO DETERMINE THE EFFECT OF MONTHLY CYCLED TESTOSTERONE REPLACEMENT IN CONJUNCTION WITH RESISTANCE EXERCISE ON MUSCLE MASS, MUSCLE STRENGTH, BONE MASS AND MARKERS OF BONE METABOLISM IN MEN AGED 35-55. SPECIFIC AIM 2B: TO DETERMINE THE EFFECT OF DAILY LEUCINE SUPPLEMENTATION IN CONJUNCTION WITH RESISTANCE EXERCISE ON MUSCLE MASS AND MUSCLE STRENGTH, BONE MASS, AND MARKERS OF BONE METABOLISM IN WOMEN AGED 35-55. CURRENT EVIDENCE SUGGESTS THAT THE COMBINATION OF TESTOSTERONE, AMINO ACIDS, AND EXERCISE WILL OPTIMIZE THE EFFECTIVENESS OF THE EXISTING EXERCISE AND NUTRITIONAL COUNTERMEASURES. RESULTS FROM THIS PROPOSAL WILL LAY THE GROUND WORK FOR THE IMPLEMENTATION OF COMBINATIONAL COUNTERMEASURES THAT WILL ADDITIVELY WORK TO MAINTAIN PREFLIGHT PHYSIOLOGY OF FEMALE AND MALE ASTRONAUTS DURING LONG-TERM SPACEFLIGHT MISSIONS.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX10AP86G  
Monday, July 24, 2017
$108,289.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
EXPOSURE TO HIGH-ENERGY HEAVY IONS (HZE) DURING SPACE TRAVEL IS A HEALTH RISK FOR ASTRONAUTS. EVEN AT LOW DOSES, EXPOSURE TO HZE CAN LEAD TO CANCER. TO BETTER UNDERSTAND THE MOLECULAR MECHANISMS OF HZE INDUCED CARCINOGENESIS WE WILL USE A MOUSE MODEL OF HZEINDUCED HEPATOCELLULAR CARCINOMA TO STUDY MICROENVIRONMENT CHANGES AFTER EXPOSURE TO LOW LEVEL HZE. A COMPREHENSIVE SYSTEMS BIOLOGY APPROACH CONSISTING OF TRANSCRIPTOMICS, LIPIDOMICS, PROTEOMICS AND METABOLOMICS WITH NOVEL DATA ANALYSIS WILL BE USED TO BUILD DETAILED BIOLOGICAL PATHWAYS AND IDENTIFY MOLECULAR MECHANISMS THAT DRIVE CARCINOGENESIS. THIS WORK WILL FURTHER OUR UNDERSTANDING OF RISK AT A MECHANISTIC LEVEL AND ALLOW THE DEVELOPMENT OF NEW MODELS FOR ESTIMATING HUMAN RISK. THIS STAGE 2 PROPOSAL IS A RESUBMISSION OF A PROPOSAL OF THE SAME TITLE SUBMITTED IN 2013 IN RESPONSE TO NASA NRA NNJ13ZSA001N WHICH INCLUDES RESPONSE TO REVIEWER COMMENTS AND ADDITIONAL NOVEL PRELIMINARY DATA ON MICROENVIRONMENTAL CHANGES OBSERVED IN AN HZE-INDUCED HCC MOUSE MODEL.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX15AD65G  
Friday, July 14, 2017
$3,500.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
IGF::OT::IGF PURPOSE: TO OBLIGATE GUARANTEED MINIMUM OF $3,500 FOR TASK AREA A FOR 1700040I UNIVERSITY OF TEXAS MEDICAL BRANCH.
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200001     HHSN272201700040I     NIHAI2016059  
Thursday, July 13, 2017
$0.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

B: IDC
IGF::OT::IGF PRE-CLINICAL MODELS OF INFECTIOUS DISEASES
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN272201700040I     NIHAI2016059  
Thursday, June 15, 2017
$25,000.00
7500: Department of Health and Human Services
75D301: CDC OFFICE OF ACQUISITION SERVICES

B: PURCHASE ORDER
YERSINIA PESTIS ANTIGENS WITH PRIMER SETS
6640: LABORATORY EQUIPMENT AND SUPPLIES

  HHSD2002017M94449P     2017Q66996  
Monday, June 12, 2017
$40,000.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
HIGHLY ENERGETIC HEAVY IONS (HZE), OF THE TYPE FOUND IN GALACTIC COSMIC RAYS, DEPOSIT ENERGY IN CLOSELY SPACED AREAS ALONG THE PATHS (TRACKS) THESE IONS TAKE AS THEY PASS THROUGH CELLS. THIS TIGHT SPACING MAKES THESE PARTICLES PARTICULARLY DAMAGING TO IMPORTANT CELLULAR COMPONENTS SUCH AS CHROMOSOMES. SOME OF THE ENERGY OF THE HZE PARTICLE CAN BE TRANSFERRED TO ELECTRONS (DELTA RAYS) WHICH CAN TRAVEL RELATIVELY LONG DISTANCES AND PRODUCE DAMAGE IN CELLS FAR REMOVED FROM THE ORIGINAL PARTICLE TRACK. THE CELL HAS MECHANISMS THAT CAN REJOIN BROKEN CHROMOSOMES BUT THESE PROCESSES CAN MAKE MISTAKES CAUSING SEGMENTS OF THE CHROMOSOMES INVOLVED TO EXCHANGE. IT IS OUR HYPOTHESIS THAT DAMAGE PRODUCED BY DELTA RAYS FROM HZE PARTICLE TRACKS CAN INTERACT WITH DAMAGE NEAR THE CENTER OF AN INDEPENDENT PARTICLE TRACK AND ADD MORE BREAKS TO AN EXCHANGE THAT MIGHT BE FORMING CLOSE TO THE CENTER OF THE SECOND TRACK. SUCH INTERACTIONS WILL ADD CURVATURE TO THE CHROMOSOME EXCHANGE BREAKPOINT DOSE RESPONSE. WE PLAN TO TEST THIS HYPOTHESIS BY IRRADIATING HUMAN FIBROBLASTS AND LYMPHOCYTES WITH PARTICLES OF DIFFERENT ENERGY CHOSEN IN SUCH A WAY THAT THEY DEPOSIT THE SAME AMOUNT OF ENERGY ALONG A SPECIFIC LENGTH OF THEIR TRACK AND MEASURE THE RESULTING CHROMOSOME EXCHANGES. THE ENERGY IMPARTED TO THE DELTA RAYS WILL BE PROPORTIONAL TO THE ENERGY OF THE HZE PARTICLE SO THAT THE DELTA RAYS FROM A HIGHER ENERGY PARTICLE CAN POTENTIALLY TRAVEL LONGER DISTANCES. THIS SUGGESTS TO US THAT THEY MAY BE ABLE TO ADD MORE BREAKS TO EXCHANGES AND INCREASE THE CURVATURE OF THE DOSE RESPONSE. CHROMOSOME ABERRATIONS ARE IMPORTANT CHANGES IN CELLS THOUGHT TO BE CAUSATIVE OR DIAGNOSTIC OF RADIATION CARCINOGENESIS. A BETTER UNDERSTANDING OF THE MECHANISMS OF THEIR FORMATION WILL REDUCE UNCERTAINTIES IN MODELS USED BY NASA TO DESIGN SPACECRAFT BETTER ABLE TO PROTECT ASTRONAUTS FROM RADIATION.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX14AC76G  
Friday, May 19, 2017
$60,000.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
HIGHLY ENERGETIC HEAVY IONS (HZE), OF THE TYPE FOUND IN GALACTIC COSMIC RAYS, DEPOSIT ENERGY IN CLOSELY SPACED AREAS ALONG THE PATHS (TRACKS) THESE IONS TAKE AS THEY PASS THROUGH CELLS. THIS TIGHT SPACING MAKES THESE PARTICLES PARTICULARLY DAMAGING TO IMPORTANT CELLULAR COMPONENTS SUCH AS CHROMOSOMES. SOME OF THE ENERGY OF THE HZE PARTICLE CAN BE TRANSFERRED TO ELECTRONS (DELTA RAYS) WHICH CAN TRAVEL RELATIVELY LONG DISTANCES AND PRODUCE DAMAGE IN CELLS FAR REMOVED FROM THE ORIGINAL PARTICLE TRACK. THE CELL HAS MECHANISMS THAT CAN REJOIN BROKEN CHROMOSOMES BUT THESE PROCESSES CAN MAKE MISTAKES CAUSING SEGMENTS OF THE CHROMOSOMES INVOLVED TO EXCHANGE. IT IS OUR HYPOTHESIS THAT DAMAGE PRODUCED BY DELTA RAYS FROM HZE PARTICLE TRACKS CAN INTERACT WITH DAMAGE NEAR THE CENTER OF AN INDEPENDENT PARTICLE TRACK AND ADD MORE BREAKS TO AN EXCHANGE THAT MIGHT BE FORMING CLOSE TO THE CENTER OF THE SECOND TRACK. SUCH INTERACTIONS WILL ADD CURVATURE TO THE CHROMOSOME EXCHANGE BREAKPOINT DOSE RESPONSE. WE PLAN TO TEST THIS HYPOTHESIS BY IRRADIATING HUMAN FIBROBLASTS AND LYMPHOCYTES WITH PARTICLES OF DIFFERENT ENERGY CHOSEN IN SUCH A WAY THAT THEY DEPOSIT THE SAME AMOUNT OF ENERGY ALONG A SPECIFIC LENGTH OF THEIR TRACK AND MEASURE THE RESULTING CHROMOSOME EXCHANGES. THE ENERGY IMPARTED TO THE DELTA RAYS WILL BE PROPORTIONAL TO THE ENERGY OF THE HZE PARTICLE SO THAT THE DELTA RAYS FROM A HIGHER ENERGY PARTICLE CAN POTENTIALLY TRAVEL LONGER DISTANCES. THIS SUGGESTS TO US THAT THEY MAY BE ABLE TO ADD MORE BREAKS TO EXCHANGES AND INCREASE THE CURVATURE OF THE DOSE RESPONSE. CHROMOSOME ABERRATIONS ARE IMPORTANT CHANGES IN CELLS THOUGHT TO BE CAUSATIVE OR DIAGNOSTIC OF RADIATION CARCINOGENESIS. A BETTER UNDERSTANDING OF THE MECHANISMS OF THEIR FORMATION WILL REDUCE UNCERTAINTIES IN MODELS USED BY NASA TO DESIGN SPACECRAFT BETTER ABLE TO PROTECT ASTRONAUTS FROM RADIATION.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX14AC76G  
Tuesday, May 16, 2017
$0.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

F: COOPERATIVE AGREEMENT
THE TRAINING REQUIREMENTS FOR SPACE MEDICINE OPERATIONAL AND RESEARCH PROVIDERS ARE UNIQUE. AS PARTNERS IN THIS SPACE MEDICINE FOCUSED RESIDENCY PROGRAM, NASA AND THE UNIVERSITY OF TEXAS MEDICAL BRANCH (UTMB) HAVE A 21-YEAR TRACK RECORD OF SUCCESSFULLY SELECTING AND TRAINING OUTSTANDING PHYSICIANS WHO PROGRESS TO ACTIVELY SUPPORT NASA AND MEET NEEDS OF THE U.S. SPACE PROGRAM. NOT ONLY ARE THE RESIDENTS TRAINED FOR SPACE MEDICINE SUPPORT AT NASA, THEY ALSO COMPLETE THE CORE COMPETENCIES SET BY THE ACCREDITATION COUNCIL ON GRADUATE MEDICAL EDUCATION (ACGME), LEADING TO CERTIFICATION IN AEROSPACE MEDICINE BY THE AMERICAN BOARD OF PREVENTIVE MEDICINE. UTMB OFFERS GRADUATE COURSES AS PART OF THE APPROVED MASTER OF PUBLIC HEALTH (MPH) WITH AN AEROSPACE MEDICINE TRACK AND PRACTICUM ACTIVITIES. OTHER EDUCATIONAL ACTIVITIES, SUCH AS JOURNAL CLUB AND AEROSPACE GRAND ROUNDS ARE ESSENTIAL TO SPACE MEDICINE PRACTITIONERS, AND ARE AVAILABLE LOCALLY AND REMOTELY FOR PHYSICIANS AT ALL THE NASA CENTERS, SATELLITE LOCATIONS, AND STREAMED LIVE. THIS ALLOWS PRACTICING PHYSICIANS TO TAKE ADVANTAGE OF OPPORTUNITIES TO IMPROVE THEIR CLINICAL AND ACADEMIC SKILLS AND MEET THE CONTINUING MEDICAL EDUCATION (CME) REQUIREMENTS OF STATE LICENSING BOARDS. UTMB ALSO COORDINATES OTHER ACTIVITIES FOR NASA PHYSICIANS AND RESIDENTS, SUCH AS VOLUNTEER SERVICE PROJECTS, PROVIDING MEDICAL SUPPORT FOR THE WINGS OVER HOUSTON AIRSHOW AND THE HOUSTON MARATHON, CME TRAINING SUCH AS ADVANCED CARDIAC LIFE SUPPORT, BASIC LIFE SUPPORT, AND PRE-HOSPITAL TRAUMA LIFE SUPPORT TRAINING, AS WELL AS OPPORTUNITIES FOR ADJUNCT FACULTY APPOINTMENTS, MEDICAL CREDENTIALING, AND TEACHING. NO OTHER ACADEMIC INSTITUTION PROVIDES ACADEMIC AND PRACTICUM ACTIVITIES SO CLOSELY TIED TO MEDICAL OPERATIONS AND SCIENCE SUPPORT IN THE SPACE PROGRAM. UTMB ALSO MAINTAINS AFFILIATION AGREEMENTS WITH MILITARY AND FEDERAL AVIATION-RELATED INSTITUTIONS SUCH AS THE USAF SCHOOL OF AEROSPACE MEDICINE, WRIGHT-PATTERSON AIR FORCE BASE, THE US ARMY SCHOOL OF AVIATION MEDICINE, AND THE FAA CIVIL AEROSPACE MEDICAL INSTITUTE THAT BENEFIT NOT ONLY NASA BUT THE MILITARY AND CIVILIAN CREWMEMBERS THESE PHYSICIANS EVENTUALLY SUPPORT. RESIDENT PHYSICIANS SUPPORTED BY THIS AGREEMENT ARE TRAINED IN ALL ASPECTS OF AEROSPACE MEDICINE, AND UPON GRADUATION ARE ABLE TO FUNCTION IN ENVIRONMENTS AS DIVERSE AS GENERAL AVIATION, COMMERCIAL AVIATION, SPACE FLIGHT, AND IN GOVERNMENTAL AND ACADEMIC INSTITUTIONS. IN PREPARATION FOR FUTURE INCREASED COOPERATION WITH THE COMMERCIAL SPACEFLIGHT INDUSTRY, RESIDENTS ARE GIVEN EXPERIENCE IN THIS ARENA AS WELL. GRADUATES OF THE AEROSPACE MEDICINE RESIDENCY PROGRAM ARE IN DEMAND, AND IT IS PREDICTED THAT THIS DEMAND WILL CONTINUE THROUGH THE LIFE CYCLE OF THE ISS AND ON TO FUTURE EXPLORATION MISSIONS. TO DATE, 30 OF THE 40 PROGRAM'S GRADUATES HAVE BEEN EMPLOYED BY NASA OR ONE OF ITS PRIMARY CONTRACTORS. THE TRAINING PARTNERSHIP PRODUCES GRADUATES THAT ARE IMMEDIATELY PRODUCTIVE WHEN HIRED. NASA AND UTMB HAVE A UNIQUE OPPORTUNITY TO CONTINUE THIS PRODUCTIVE PARTNERSHIP IN TRAINING THE NEXT GENERATION OF SPACE MEDICINE PHYSICIANS TO LEAD THE FIELD IN RESEARCH AND OPERATIONAL SUPPORT. UTMB PROPOSES TO CONTINUE PRODUCING GRADUATES TRAINED AND BOARD ELIGIBLE IN AEROSPACE MEDICINE, WITH AN EMPHASIS IN SPACE. UTMB IS REQUESTING NASA'S CONTINUED FINANCIAL SUPPORT FOR GRADUATE MEDICAL EDUCATION TRAINING IN AEROSPACE MEDICINE. IN ORDER TO FACILITATE LONG TERM PLANNING, UTMB IS SEEKING A NEW FIVE YEAR COOPERATIVE AGREEMENT.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX16AC91A  
Wednesday, May 3, 2017
$25,000.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
DURING DEEP SPACE EXPLORATION, PERSONNEL WILL BE EXPOSED TO LOW-FLUENCES OF DENSELY-IONIZING CHARGED PARTICLES OF INTERMEDIATE AND HIGH ATOMIC NUMBER. FOR A GIVEN DOSE THESE ARE ALMOST CERTAINLY MORE LIKELY TO CAUSE CANCER THAN THE SPARSELY IONIZING TYPES OF RADIATION TYPICALLY ENCOUNTERED ON EARTH, SUCH AS X- AND GAMMA-RAYS. IT IS NOT POSSIBLE TO DETERMINE THE CARCINOGENIC POTENTIAL OF SUCH RADIATIONS DIRECTLY IN ASTRONAUTS, SO IT BECOMES NECESSARY TO RELY ON SURROGATE EXPERIMENTAL SYSTEMS TO PROVIDE THIS INFORMATION. BECAUSE THEY CAUSE CANCER, BECAUSE THEY FOUND IN VIRTUALLY ALL CANCERS, AND BECAUSE THEY RESPOND TO DOSE IN BIOPHYSICALLY PREDICTABLE WAYS, THE FORMATION NONLETHAL (TRANSMISSIBLE) CHROMOSOME ABERRATIONS REPRESENTS AN EXCELLENT SURROGATE MODEL TO STUDY RADIATION CARCINOGENESIS. AND YET, ONLY RECENTLY HAVE WE BEGUN TO REALLY UNDERSTAND THE MOLECULAR PROCESSES GOVERNING ABERRATION FORMATION, INCLUDING DIFFERENCES THAT PROBABLY EXIST IN THE WAY THAT THEY ARE PRODUCED BY SPARSELY- VERSUS DENSELY-IONIZING RADIATIONS. WE PROPOSE USING WHOLE GENOME SEQUENCING TO CHARACTERIZE STRUCTURAL CHANGES TO THE DNA OF NORMAL HUMAN CELLS THAT ACCOMPANY THE FORMATION OF TRANSMISSIBLE CHROMOSOME ABERRATIONS. WE FOCUS OUR STUDY ON PORTIONS OF THE GCR SPECTRA THAT ARE LIKELY TO BE ENCOUNTERED IN DEEP SPACE, AND WHICH WE HYPOTHESIZE WILL ELICIT DIFFERENT BIOLOGICAL RESPONSES AT THE DNA LEVEL.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX15AG74G  
Wednesday, May 3, 2017
$145,000.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
EXPOSURE TO HIGH-ENERGY HEAVY IONS (HZE) DURING SPACE TRAVEL IS A HEALTH RISK FOR ASTRONAUTS. EVEN AT LOW DOSES, EXPOSURE TO HZE CAN LEAD TO CANCER. TO BETTER UNDERSTAND THE MOLECULAR MECHANISMS OF HZE INDUCED CARCINOGENESIS WE WILL USE A MOUSE MODEL OF HZEINDUCED HEPATOCELLULAR CARCINOMA TO STUDY MICROENVIRONMENT CHANGES AFTER EXPOSURE TO LOW LEVEL HZE. A COMPREHENSIVE SYSTEMS BIOLOGY APPROACH CONSISTING OF TRANSCRIPTOMICS, LIPIDOMICS, PROTEOMICS AND METABOLOMICS WITH NOVEL DATA ANALYSIS WILL BE USED TO BUILD DETAILED BIOLOGICAL PATHWAYS AND IDENTIFY MOLECULAR MECHANISMS THAT DRIVE CARCINOGENESIS. THIS WORK WILL FURTHER OUR UNDERSTANDING OF RISK AT A MECHANISTIC LEVEL AND ALLOW THE DEVELOPMENT OF NEW MODELS FOR ESTIMATING HUMAN RISK. THIS STAGE 2 PROPOSAL IS A RESUBMISSION OF A PROPOSAL OF THE SAME TITLE SUBMITTED IN 2013 IN RESPONSE TO NASA NRA NNJ13ZSA001N WHICH INCLUDES RESPONSE TO REVIEWER COMMENTS AND ADDITIONAL NOVEL PRELIMINARY DATA ON MICROENVIRONMENTAL CHANGES OBSERVED IN AN HZE-INDUCED HCC MOUSE MODEL.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX15AD65G  
Friday, April 14, 2017
($275.00)
1200: Department of Agriculture
126395: USDA APHIS MRPBS

B: PURCHASE ORDER
IGF::OT::IGF
Q301: MEDICAL- LABORATORY TESTING

  AG6395P150461  
Tuesday, March 21, 2017
($69,301.38)
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
OTHER FUNCTION: TITLE - ANIMAL MODELS OF INFECTIOUS DISEASES. THE PURPOSE OF THIS MODIFICATION IS TO CLOSE OUT THE TASK AND DE-OBLIGATE THE REMAINING FUNDING IN THE AMOUNT OF $69,301.38.
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200004     HHSN272201000040I  
Tuesday, March 21, 2017
$0.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
IGF::OT::IGF - TITLE _ ANIMAL MODELS OF INFECTIOUS DISEASES; TASK A104
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200012     HHSN272201000040I  
Tuesday, March 21, 2017
($68,601.31)
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
IGF::OT::IGF THE PURPOSE OF THIS MODIFICATION IS TO CLOSE OUT THE TASK ORDER AND DE-OBLIGATE THE REMAINING FUNDS IN THE AMOUNT OF $68,601.31.
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200007     HHSN272201000040I  
Tuesday, March 21, 2017
$0.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
IGF::OT::IGF THE PURPOSE OF THIS MODIFICATION IS TO: (1) EXTEND THE COMPLETION DATE OF OPTION 2B FROM JUNE 19, 2017 TO AUGUST 31, 2017 AT NO ADDITIONAL COST TO THE GOVERNMENT; AND (2) UPDATE THE COMPLETION PERIOD IN ARTICLE F.1.
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200009     HHSN272201000040I  
Tuesday, March 21, 2017
$0.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
IGF::OT::IGF - TITLE_ANIMAL MODELS OF INFECTIOUS DISEASES; TASK A68
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200008     HHSN272201000040I  
Thursday, March 16, 2017
$689,163.00
9700: Department of Defense
HDTRA1: DEFENSE THREAT REDUCTION AGENCY

D: DEFINITIVE CONTRACT
QUANTITATIVE DOSE EBOLA IGF::OT::IGF
AD92: R&D- DEFENSE OTHER: OTHER (APPLIED RESEARCH/EXPLORATORY DEVELOPMENT)

  HDTRA117C0009  
Thursday, March 16, 2017
$270,978.00
9700: Department of Defense
HDTRA1: DEFENSE THREAT REDUCTION AGENCY

D: DEFINITIVE CONTRACT
IGF::OT::IGF - BASE PERIOD
AD92: R&D- DEFENSE OTHER: OTHER (APPLIED RESEARCH/EXPLORATORY DEVELOPMENT)

  HDTRA117C0015  
Thursday, March 16, 2017
$131,064.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
IGF::OT::IGF TITLE - TASK A94, ANIMALS MODELS OF INFECTIOUS DISEASES
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200011     HHSN272201000040I  
Thursday, March 16, 2017
$388,927.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
IGF::OT::IGF - TITLE: TASK A71, "EVALUATION OF THERAPEUTICS AND VACCINES IN MOUSE MODELS OF DENGUE VIRUS."
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200009     HHSN272201000040I  
Tuesday, February 28, 2017
$0.00
9700: Department of Defense
HDTRA1: DEFENSE THREAT REDUCTION AGENCY

D: DEFINITIVE CONTRACT
QUANTITATIVE DOSE EBOLA IGF::OT::IGF
AD92: R&D- DEFENSE OTHER: OTHER (APPLIED RESEARCH/EXPLORATORY DEVELOPMENT)

  HDTRA117C0009  
Thursday, February 23, 2017
$139,265.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
IGF::OT::IGF TITLE - TASK A94, ANIMALS MODELS OF INFECTIOUS DISEASES
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200011     HHSN272201000040I  
Tuesday, February 21, 2017
$643,620.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
IGF::OT::IGF - TITLE _ ANIMAL MODELS OF INFECTIOUS DISEASES; TASK A104
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200012     HHSN272201000040I  
Monday, February 13, 2017
$197,699.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
IGF::OT::IGF - TITLE_ANIMAL MODELS OF INFECTIOUS DISEASES; TASK A68
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200008     HHSN272201000040I  
Monday, January 30, 2017
$500,000.00
9700: Department of Defense
HDTRA1: DEFENSE THREAT REDUCTION AGENCY

D: DEFINITIVE CONTRACT
QUANTITATIVE DOSE EBOLA IGF::OT::IGF
AD92: R&D- DEFENSE OTHER: OTHER (APPLIED RESEARCH/EXPLORATORY DEVELOPMENT)

  HDTRA117C0009  
Thursday, January 26, 2017
($1,731.13)
3600: Department of Veterans Affairs
36C24E: SAO EAST (00240E)

D: DEFINITIVE CONTRACT
IGF::OT::IGF MICE BREEDING
AJ92: R&D- GENERAL SCIENCE/TECHNOLOGY: OTHER (APPLIED RESEARCH/EXPLORATORY DEVELOPMENT)

  VA26815C0041     VA268-15-Q-0106  
Wednesday, January 25, 2017
$0.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
IGF::OT::IGF - TITLE_ANIMAL MODELS OF INFECTIOUS DISEASES; TASK A68
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200008     HHSN272201000040I  
Thursday, January 19, 2017
($5,913.94)
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
OTHER FUNCTION: TITLE - ANIMAL MODELS OF INFECTIOUS DISEASES
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200004     HHSN272201000040I  
Friday, January 13, 2017
($80,891.37)
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
OTHER FUNCTION: TITLE - ANIMAL MODELS OF INFECTIOUS DISEASES
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200003     HHSN272201000040I  
Friday, January 13, 2017
$70,000.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
EXPOSURE TO HIGH-ENERGY HEAVY IONS (HZE) DURING SPACE TRAVEL IS A HEALTH RISK FOR ASTRONAUTS. EVEN AT LOW DOSES, EXPOSURE TO HZE CAN LEAD TO CANCER. TO BETTER UNDERSTAND THE MOLECULAR MECHANISMS OF HZE INDUCED CARCINOGENESIS WE WILL USE A MOUSE MODEL OF HZEINDUCED HEPATOCELLULAR CARCINOMA TO STUDY MICROENVIRONMENT CHANGES AFTER EXPOSURE TO LOW LEVEL HZE. A COMPREHENSIVE SYSTEMS BIOLOGY APPROACH CONSISTING OF TRANSCRIPTOMICS, LIPIDOMICS, PROTEOMICS AND METABOLOMICS WITH NOVEL DATA ANALYSIS WILL BE USED TO BUILD DETAILED BIOLOGICAL PATHWAYS AND IDENTIFY MOLECULAR MECHANISMS THAT DRIVE CARCINOGENESIS. THIS WORK WILL FURTHER OUR UNDERSTANDING OF RISK AT A MECHANISTIC LEVEL AND ALLOW THE DEVELOPMENT OF NEW MODELS FOR ESTIMATING HUMAN RISK. THIS STAGE 2 PROPOSAL IS A RESUBMISSION OF A PROPOSAL OF THE SAME TITLE SUBMITTED IN 2013 IN RESPONSE TO NASA NRA NNJ13ZSA001N WHICH INCLUDES RESPONSE TO REVIEWER COMMENTS AND ADDITIONAL NOVEL PRELIMINARY DATA ON MICROENVIRONMENTAL CHANGES OBSERVED IN AN HZE-INDUCED HCC MOUSE MODEL.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX15AD65G  
Wednesday, January 11, 2017
$229,504.35
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

F: COOPERATIVE AGREEMENT
THE TRAINING REQUIREMENTS FOR SPACE MEDICINE OPERATIONAL AND RESEARCH PROVIDERS ARE UNIQUE. AS PARTNERS IN THIS SPACE MEDICINE FOCUSED RESIDENCY PROGRAM, NASA AND THE UNIVERSITY OF TEXAS MEDICAL BRANCH (UTMB) HAVE A 21-YEAR TRACK RECORD OF SUCCESSFULLY SELECTING AND TRAINING OUTSTANDING PHYSICIANS WHO PROGRESS TO ACTIVELY SUPPORT NASA AND MEET NEEDS OF THE U.S. SPACE PROGRAM. NOT ONLY ARE THE RESIDENTS TRAINED FOR SPACE MEDICINE SUPPORT AT NASA, THEY ALSO COMPLETE THE CORE COMPETENCIES SET BY THE ACCREDITATION COUNCIL ON GRADUATE MEDICAL EDUCATION (ACGME), LEADING TO CERTIFICATION IN AEROSPACE MEDICINE BY THE AMERICAN BOARD OF PREVENTIVE MEDICINE. UTMB OFFERS GRADUATE COURSES AS PART OF THE APPROVED MASTER OF PUBLIC HEALTH (MPH) WITH AN AEROSPACE MEDICINE TRACK AND PRACTICUM ACTIVITIES. OTHER EDUCATIONAL ACTIVITIES, SUCH AS JOURNAL CLUB AND AEROSPACE GRAND ROUNDS ARE ESSENTIAL TO SPACE MEDICINE PRACTITIONERS, AND ARE AVAILABLE LOCALLY AND REMOTELY FOR PHYSICIANS AT ALL THE NASA CENTERS, SATELLITE LOCATIONS, AND STREAMED LIVE. THIS ALLOWS PRACTICING PHYSICIANS TO TAKE ADVANTAGE OF OPPORTUNITIES TO IMPROVE THEIR CLINICAL AND ACADEMIC SKILLS AND MEET THE CONTINUING MEDICAL EDUCATION (CME) REQUIREMENTS OF STATE LICENSING BOARDS. UTMB ALSO COORDINATES OTHER ACTIVITIES FOR NASA PHYSICIANS AND RESIDENTS, SUCH AS VOLUNTEER SERVICE PROJECTS, PROVIDING MEDICAL SUPPORT FOR THE WINGS OVER HOUSTON AIRSHOW AND THE HOUSTON MARATHON, CME TRAINING SUCH AS ADVANCED CARDIAC LIFE SUPPORT, BASIC LIFE SUPPORT, AND PRE-HOSPITAL TRAUMA LIFE SUPPORT TRAINING, AS WELL AS OPPORTUNITIES FOR ADJUNCT FACULTY APPOINTMENTS, MEDICAL CREDENTIALING, AND TEACHING. NO OTHER ACADEMIC INSTITUTION PROVIDES ACADEMIC AND PRACTICUM ACTIVITIES SO CLOSELY TIED TO MEDICAL OPERATIONS AND SCIENCE SUPPORT IN THE SPACE PROGRAM. UTMB ALSO MAINTAINS AFFILIATION AGREEMENTS WITH MILITARY AND FEDERAL AVIATION-RELATED INSTITUTIONS SUCH AS THE USAF SCHOOL OF AEROSPACE MEDICINE, WRIGHT-PATTERSON AIR FORCE BASE, THE US ARMY SCHOOL OF AVIATION MEDICINE, AND THE FAA CIVIL AEROSPACE MEDICAL INSTITUTE THAT BENEFIT NOT ONLY NASA BUT THE MILITARY AND CIVILIAN CREWMEMBERS THESE PHYSICIANS EVENTUALLY SUPPORT. RESIDENT PHYSICIANS SUPPORTED BY THIS AGREEMENT ARE TRAINED IN ALL ASPECTS OF AEROSPACE MEDICINE, AND UPON GRADUATION ARE ABLE TO FUNCTION IN ENVIRONMENTS AS DIVERSE AS GENERAL AVIATION, COMMERCIAL AVIATION, SPACE FLIGHT, AND IN GOVERNMENTAL AND ACADEMIC INSTITUTIONS. IN PREPARATION FOR FUTURE INCREASED COOPERATION WITH THE COMMERCIAL SPACEFLIGHT INDUSTRY, RESIDENTS ARE GIVEN EXPERIENCE IN THIS ARENA AS WELL. GRADUATES OF THE AEROSPACE MEDICINE RESIDENCY PROGRAM ARE IN DEMAND, AND IT IS PREDICTED THAT THIS DEMAND WILL CONTINUE THROUGH THE LIFE CYCLE OF THE ISS AND ON TO FUTURE EXPLORATION MISSIONS. TO DATE, 30 OF THE 40 PROGRAM'S GRADUATES HAVE BEEN EMPLOYED BY NASA OR ONE OF ITS PRIMARY CONTRACTORS. THE TRAINING PARTNERSHIP PRODUCES GRADUATES THAT ARE IMMEDIATELY PRODUCTIVE WHEN HIRED. NASA AND UTMB HAVE A UNIQUE OPPORTUNITY TO CONTINUE THIS PRODUCTIVE PARTNERSHIP IN TRAINING THE NEXT GENERATION OF SPACE MEDICINE PHYSICIANS TO LEAD THE FIELD IN RESEARCH AND OPERATIONAL SUPPORT. UTMB PROPOSES TO CONTINUE PRODUCING GRADUATES TRAINED AND BOARD ELIGIBLE IN AEROSPACE MEDICINE, WITH AN EMPHASIS IN SPACE. UTMB IS REQUESTING NASA'S CONTINUED FINANCIAL SUPPORT FOR GRADUATE MEDICAL EDUCATION TRAINING IN AEROSPACE MEDICINE. IN ORDER TO FACILITATE LONG TERM PLANNING, UTMB IS SEEKING A NEW FIVE YEAR COOPERATIVE AGREEMENT.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX16AC91A  
Wednesday, January 11, 2017
$0.00
7500: Department of Health and Human Services
75F401: FDA OFFICE OF ACQ GRANT SVCS

D: DEFINITIVE CONTRACT
IGF::CL::IGF STUDY FOR THE COLLECTION OF PHYSIOLOGICAL DATA PRIOR TO SHOCK
B526: SPECIAL STUDIES/ANALYSIS- OCEANOLOGICAL

  HHSF223201450003A  
Wednesday, January 11, 2017
$70,000.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
HIGHLY ENERGETIC HEAVY IONS (HZE), OF THE TYPE FOUND IN GALACTIC COSMIC RAYS, DEPOSIT ENERGY IN CLOSELY SPACED AREAS ALONG THE PATHS (TRACKS) THESE IONS TAKE AS THEY PASS THROUGH CELLS. THIS TIGHT SPACING MAKES THESE PARTICLES PARTICULARLY DAMAGING TO IMPORTANT CELLULAR COMPONENTS SUCH AS CHROMOSOMES. SOME OF THE ENERGY OF THE HZE PARTICLE CAN BE TRANSFERRED TO ELECTRONS (DELTA RAYS) WHICH CAN TRAVEL RELATIVELY LONG DISTANCES AND PRODUCE DAMAGE IN CELLS FAR REMOVED FROM THE ORIGINAL PARTICLE TRACK. THE CELL HAS MECHANISMS THAT CAN REJOIN BROKEN CHROMOSOMES BUT THESE PROCESSES CAN MAKE MISTAKES CAUSING SEGMENTS OF THE CHROMOSOMES INVOLVED TO EXCHANGE. IT IS OUR HYPOTHESIS THAT DAMAGE PRODUCED BY DELTA RAYS FROM HZE PARTICLE TRACKS CAN INTERACT WITH DAMAGE NEAR THE CENTER OF AN INDEPENDENT PARTICLE TRACK AND ADD MORE BREAKS TO AN EXCHANGE THAT MIGHT BE FORMING CLOSE TO THE CENTER OF THE SECOND TRACK. SUCH INTERACTIONS WILL ADD CURVATURE TO THE CHROMOSOME EXCHANGE BREAKPOINT DOSE RESPONSE. WE PLAN TO TEST THIS HYPOTHESIS BY IRRADIATING HUMAN FIBROBLASTS AND LYMPHOCYTES WITH PARTICLES OF DIFFERENT ENERGY CHOSEN IN SUCH A WAY THAT THEY DEPOSIT THE SAME AMOUNT OF ENERGY ALONG A SPECIFIC LENGTH OF THEIR TRACK AND MEASURE THE RESULTING CHROMOSOME EXCHANGES. THE ENERGY IMPARTED TO THE DELTA RAYS WILL BE PROPORTIONAL TO THE ENERGY OF THE HZE PARTICLE SO THAT THE DELTA RAYS FROM A HIGHER ENERGY PARTICLE CAN POTENTIALLY TRAVEL LONGER DISTANCES. THIS SUGGESTS TO US THAT THEY MAY BE ABLE TO ADD MORE BREAKS TO EXCHANGES AND INCREASE THE CURVATURE OF THE DOSE RESPONSE. CHROMOSOME ABERRATIONS ARE IMPORTANT CHANGES IN CELLS THOUGHT TO BE CAUSATIVE OR DIAGNOSTIC OF RADIATION CARCINOGENESIS. A BETTER UNDERSTANDING OF THE MECHANISMS OF THEIR FORMATION WILL REDUCE UNCERTAINTIES IN MODELS USED BY NASA TO DESIGN SPACECRAFT BETTER ABLE TO PROTECT ASTRONAUTS FROM RADIATION.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX14AC76G  
Wednesday, December 7, 2016
$11,043.59
9700: Department of Defense
N0622A: NAVY MEDICINE PROFESSIONAL

C: DELIVERY ORDER
IGF::OT::IGF TUITION AND FEES
U005: EDUCATION/TRAINING- TUITION/REGISTRATION/MEMBERSHIP FEES

  8E44     N0014098G2541  
Tuesday, November 29, 2016
$0.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
OTHER FUNCTION: TITLE - ANIMAL MODELS OF INFECTIOUS DISEASES
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200003     HHSN272201000040I  
Tuesday, November 22, 2016
$247,374.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
IGF::OT::IGF - TITLE: TASK A71, "EVALUATION OF THERAPEUTICS AND VACCINES IN MOUSE MODELS OF DENGUE VIRUS."
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200009     HHSN272201000040I  
Friday, October 14, 2016
$100,000.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
DURING DEEP SPACE EXPLORATION, PERSONNEL WILL BE EXPOSED TO LOW-FLUENCES OF DENSELY-IONIZING CHARGED PARTICLES OF INTERMEDIATE AND HIGH ATOMIC NUMBER. FOR A GIVEN DOSE THESE ARE ALMOST CERTAINLY MORE LIKELY TO CAUSE CANCER THAN THE SPARSELY IONIZING TYPES OF RADIATION TYPICALLY ENCOUNTERED ON EARTH, SUCH AS X- AND GAMMA-RAYS. IT IS NOT POSSIBLE TO DETERMINE THE CARCINOGENIC POTENTIAL OF SUCH RADIATIONS DIRECTLY IN ASTRONAUTS, SO IT BECOMES NECESSARY TO RELY ON SURROGATE EXPERIMENTAL SYSTEMS TO PROVIDE THIS INFORMATION. BECAUSE THEY CAUSE CANCER, BECAUSE THEY FOUND IN VIRTUALLY ALL CANCERS, AND BECAUSE THEY RESPOND TO DOSE IN BIOPHYSICALLY PREDICTABLE WAYS, THE FORMATION NONLETHAL (TRANSMISSIBLE) CHROMOSOME ABERRATIONS REPRESENTS AN EXCELLENT SURROGATE MODEL TO STUDY RADIATION CARCINOGENESIS. AND YET, ONLY RECENTLY HAVE WE BEGUN TO REALLY UNDERSTAND THE MOLECULAR PROCESSES GOVERNING ABERRATION FORMATION, INCLUDING DIFFERENCES THAT PROBABLY EXIST IN THE WAY THAT THEY ARE PRODUCED BY SPARSELY- VERSUS DENSELY-IONIZING RADIATIONS. WE PROPOSE USING WHOLE GENOME SEQUENCING TO CHARACTERIZE STRUCTURAL CHANGES TO THE DNA OF NORMAL HUMAN CELLS THAT ACCOMPANY THE FORMATION OF TRANSMISSIBLE CHROMOSOME ABERRATIONS. WE FOCUS OUR STUDY ON PORTIONS OF THE GCR SPECTRA THAT ARE LIKELY TO BE ENCOUNTERED IN DEEP SPACE, AND WHICH WE HYPOTHESIZE WILL ELICIT DIFFERENT BIOLOGICAL RESPONSES AT THE DNA LEVEL.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX15AG74G  
Friday, October 14, 2016
$100,000.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
HIGHLY ENERGETIC HEAVY IONS (HZE), OF THE TYPE FOUND IN GALACTIC COSMIC RAYS, DEPOSIT ENERGY IN CLOSELY SPACED AREAS ALONG THE PATHS (TRACKS) THESE IONS TAKE AS THEY PASS THROUGH CELLS. THIS TIGHT SPACING MAKES THESE PARTICLES PARTICULARLY DAMAGING TO IMPORTANT CELLULAR COMPONENTS SUCH AS CHROMOSOMES. SOME OF THE ENERGY OF THE HZE PARTICLE CAN BE TRANSFERRED TO ELECTRONS (DELTA RAYS) WHICH CAN TRAVEL RELATIVELY LONG DISTANCES AND PRODUCE DAMAGE IN CELLS FAR REMOVED FROM THE ORIGINAL PARTICLE TRACK. THE CELL HAS MECHANISMS THAT CAN REJOIN BROKEN CHROMOSOMES BUT THESE PROCESSES CAN MAKE MISTAKES CAUSING SEGMENTS OF THE CHROMOSOMES INVOLVED TO EXCHANGE. IT IS OUR HYPOTHESIS THAT DAMAGE PRODUCED BY DELTA RAYS FROM HZE PARTICLE TRACKS CAN INTERACT WITH DAMAGE NEAR THE CENTER OF AN INDEPENDENT PARTICLE TRACK AND ADD MORE BREAKS TO AN EXCHANGE THAT MIGHT BE FORMING CLOSE TO THE CENTER OF THE SECOND TRACK. SUCH INTERACTIONS WILL ADD CURVATURE TO THE CHROMOSOME EXCHANGE BREAKPOINT DOSE RESPONSE. WE PLAN TO TEST THIS HYPOTHESIS BY IRRADIATING HUMAN FIBROBLASTS AND LYMPHOCYTES WITH PARTICLES OF DIFFERENT ENERGY CHOSEN IN SUCH A WAY THAT THEY DEPOSIT THE SAME AMOUNT OF ENERGY ALONG A SPECIFIC LENGTH OF THEIR TRACK AND MEASURE THE RESULTING CHROMOSOME EXCHANGES. THE ENERGY IMPARTED TO THE DELTA RAYS WILL BE PROPORTIONAL TO THE ENERGY OF THE HZE PARTICLE SO THAT THE DELTA RAYS FROM A HIGHER ENERGY PARTICLE CAN POTENTIALLY TRAVEL LONGER DISTANCES. THIS SUGGESTS TO US THAT THEY MAY BE ABLE TO ADD MORE BREAKS TO EXCHANGES AND INCREASE THE CURVATURE OF THE DOSE RESPONSE. CHROMOSOME ABERRATIONS ARE IMPORTANT CHANGES IN CELLS THOUGHT TO BE CAUSATIVE OR DIAGNOSTIC OF RADIATION CARCINOGENESIS. A BETTER UNDERSTANDING OF THE MECHANISMS OF THEIR FORMATION WILL REDUCE UNCERTAINTIES IN MODELS USED BY NASA TO DESIGN SPACECRAFT BETTER ABLE TO PROTECT ASTRONAUTS FROM RADIATION.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX14AC76G  
Wednesday, October 12, 2016
$125,000.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
EXPOSURE TO HIGH-ENERGY HEAVY IONS (HZE) DURING SPACE TRAVEL IS A HEALTH RISK FOR ASTRONAUTS. EVEN AT LOW DOSES, EXPOSURE TO HZE CAN LEAD TO CANCER. TO BETTER UNDERSTAND THE MOLECULAR MECHANISMS OF HZE INDUCED CARCINOGENESIS WE WILL USE A MOUSE MODEL OF HZEINDUCED HEPATOCELLULAR CARCINOMA TO STUDY MICROENVIRONMENT CHANGES AFTER EXPOSURE TO LOW LEVEL HZE. A COMPREHENSIVE SYSTEMS BIOLOGY APPROACH CONSISTING OF TRANSCRIPTOMICS, LIPIDOMICS, PROTEOMICS AND METABOLOMICS WITH NOVEL DATA ANALYSIS WILL BE USED TO BUILD DETAILED BIOLOGICAL PATHWAYS AND IDENTIFY MOLECULAR MECHANISMS THAT DRIVE CARCINOGENESIS. THIS WORK WILL FURTHER OUR UNDERSTANDING OF RISK AT A MECHANISTIC LEVEL AND ALLOW THE DEVELOPMENT OF NEW MODELS FOR ESTIMATING HUMAN RISK. THIS STAGE 2 PROPOSAL IS A RESUBMISSION OF A PROPOSAL OF THE SAME TITLE SUBMITTED IN 2013 IN RESPONSE TO NASA NRA NNJ13ZSA001N WHICH INCLUDES RESPONSE TO REVIEWER COMMENTS AND ADDITIONAL NOVEL PRELIMINARY DATA ON MICROENVIRONMENTAL CHANGES OBSERVED IN AN HZE-INDUCED HCC MOUSE MODEL.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX15AD65G  
Thursday, September 8, 2016
$0.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
OTHER FUNCTION: TITLE - TASK A07, DEVELOPMENT OF A DIABETIC MOUSE MODEL FOR PROOF OF CONCEPT TESTING.
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200005     HHSN272201000040I  
Wednesday, August 24, 2016
$148,660.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
IGF::OT::IGF - TITLE: TASK A71, "EVALUATION OF THERAPEUTICS AND VACCINES IN MOUSE MODELS OF DENGUE VIRUS."
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200009     HHSN272201000040I  
Wednesday, August 24, 2016
$16,389.00
9700: Department of Defense
N0622A: NAVY MEDICINE PROFESSIONAL

C: DELIVERY ORDER
IGF::OT::IGF TUITION AND FEES
U005: EDUCATION/TRAINING- TUITION/REGISTRATION/MEMBERSHIP FEES

  8E44     N0014098G2541  
Friday, August 19, 2016
$24,750.00
3600: Department of Veterans Affairs
36C24E: SAO EAST (00240E)

D: DEFINITIVE CONTRACT
IGF::OT::IGF MICE BREEDING
AJ92: R&D- GENERAL SCIENCE/TECHNOLOGY: OTHER (APPLIED RESEARCH/EXPLORATORY DEVELOPMENT)

  VA26815C0041     VA268-15-Q-0106  
Friday, August 19, 2016
$150,000.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
HIGHLY ENERGETIC HEAVY IONS (HZE), OF THE TYPE FOUND IN GALACTIC COSMIC RAYS, DEPOSIT ENERGY IN CLOSELY SPACED AREAS ALONG THE PATHS (TRACKS) THESE IONS TAKE AS THEY PASS THROUGH CELLS. THIS TIGHT SPACING MAKES THESE PARTICLES PARTICULARLY DAMAGING TO IMPORTANT CELLULAR COMPONENTS SUCH AS CHROMOSOMES. SOME OF THE ENERGY OF THE HZE PARTICLE CAN BE TRANSFERRED TO ELECTRONS (DELTA RAYS) WHICH CAN TRAVEL RELATIVELY LONG DISTANCES AND PRODUCE DAMAGE IN CELLS FAR REMOVED FROM THE ORIGINAL PARTICLE TRACK. THE CELL HAS MECHANISMS THAT CAN REJOIN BROKEN CHROMOSOMES BUT THESE PROCESSES CAN MAKE MISTAKES CAUSING SEGMENTS OF THE CHROMOSOMES INVOLVED TO EXCHANGE. IT IS OUR HYPOTHESIS THAT DAMAGE PRODUCED BY DELTA RAYS FROM HZE PARTICLE TRACKS CAN INTERACT WITH DAMAGE NEAR THE CENTER OF AN INDEPENDENT PARTICLE TRACK AND ADD MORE BREAKS TO AN EXCHANGE THAT MIGHT BE FORMING CLOSE TO THE CENTER OF THE SECOND TRACK. SUCH INTERACTIONS WILL ADD CURVATURE TO THE CHROMOSOME EXCHANGE BREAKPOINT DOSE RESPONSE. WE PLAN TO TEST THIS HYPOTHESIS BY IRRADIATING HUMAN FIBROBLASTS AND LYMPHOCYTES WITH PARTICLES OF DIFFERENT ENERGY CHOSEN IN SUCH A WAY THAT THEY DEPOSIT THE SAME AMOUNT OF ENERGY ALONG A SPECIFIC LENGTH OF THEIR TRACK AND MEASURE THE RESULTING CHROMOSOME EXCHANGES. THE ENERGY IMPARTED TO THE DELTA RAYS WILL BE PROPORTIONAL TO THE ENERGY OF THE HZE PARTICLE SO THAT THE DELTA RAYS FROM A HIGHER ENERGY PARTICLE CAN POTENTIALLY TRAVEL LONGER DISTANCES. THIS SUGGESTS TO US THAT THEY MAY BE ABLE TO ADD MORE BREAKS TO EXCHANGES AND INCREASE THE CURVATURE OF THE DOSE RESPONSE. CHROMOSOME ABERRATIONS ARE IMPORTANT CHANGES IN CELLS THOUGHT TO BE CAUSATIVE OR DIAGNOSTIC OF RADIATION CARCINOGENESIS. A BETTER UNDERSTANDING OF THE MECHANISMS OF THEIR FORMATION WILL REDUCE UNCERTAINTIES IN MODELS USED BY NASA TO DESIGN SPACECRAFT BETTER ABLE TO PROTECT ASTRONAUTS FROM RADIATION.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX14AC76G  
Wednesday, August 17, 2016
$489,046.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
IGF::OT::IGF 1000040I UNIVERSITY OF TEXAS MEDICAL BRANCH; TO AWARD TO A104 BASE; BIOD CAN 8470038; $489,046.00
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200012     HHSN272201000040I  
Wednesday, August 3, 2016
$197,699.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
IGF::OT::IGF - TITLE_ANIMAL MODELS OF INFECTIOUS DISEASES; TASK A68
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200008     HHSN272201000040I  
Thursday, July 28, 2016
$146,766.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
IGF::OT::IGF TITLE - TASK A94, ANIMALS MODELS OF INFECTIOUS DISEASES
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200011     HHSN272201000040I  
Tuesday, July 26, 2016
$0.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
DURING DEEP SPACE EXPLORATION, PERSONNEL WILL BE EXPOSED TO LOW-FLUENCES OF DENSELY-IONIZING CHARGED PARTICLES OF INTERMEDIATE AND HIGH ATOMIC NUMBER. FOR A GIVEN DOSE THESE ARE ALMOST CERTAINLY MORE LIKELY TO CAUSE CANCER THAN THE SPARSELY IONIZING TYPES OF RADIATION TYPICALLY ENCOUNTERED ON EARTH, SUCH AS X- AND GAMMA-RAYS. IT IS NOT POSSIBLE TO DETERMINE THE CARCINOGENIC POTENTIAL OF SUCH RADIATIONS DIRECTLY IN ASTRONAUTS, SO IT BECOMES NECESSARY TO RELY ON SURROGATE EXPERIMENTAL SYSTEMS TO PROVIDE THIS INFORMATION. BECAUSE THEY CAUSE CANCER, BECAUSE THEY FOUND IN VIRTUALLY ALL CANCERS, AND BECAUSE THEY RESPOND TO DOSE IN BIOPHYSICALLY PREDICTABLE WAYS, THE FORMATION NONLETHAL (TRANSMISSIBLE) CHROMOSOME ABERRATIONS REPRESENTS AN EXCELLENT SURROGATE MODEL TO STUDY RADIATION CARCINOGENESIS. AND YET, ONLY RECENTLY HAVE WE BEGUN TO REALLY UNDERSTAND THE MOLECULAR PROCESSES GOVERNING ABERRATION FORMATION, INCLUDING DIFFERENCES THAT PROBABLY EXIST IN THE WAY THAT THEY ARE PRODUCED BY SPARSELY- VERSUS DENSELY-IONIZING RADIATIONS. WE PROPOSE USING WHOLE GENOME SEQUENCING TO CHARACTERIZE STRUCTURAL CHANGES TO THE DNA OF NORMAL HUMAN CELLS THAT ACCOMPANY THE FORMATION OF TRANSMISSIBLE CHROMOSOME ABERRATIONS. WE FOCUS OUR STUDY ON PORTIONS OF THE GCR SPECTRA THAT ARE LIKELY TO BE ENCOUNTERED IN DEEP SPACE, AND WHICH WE HYPOTHESIZE WILL ELICIT DIFFERENT BIOLOGICAL RESPONSES AT THE DNA LEVEL.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX15AG74G  
Friday, July 22, 2016
$0.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
EXPOSURE TO HIGH-ENERGY HEAVY IONS (HZE) DURING SPACE TRAVEL IS A HEALTH RISK FOR ASTRONAUTS. EVEN AT LOW DOSES, EXPOSURE TO HZE CAN LEAD TO CANCER. TO BETTER UNDERSTAND THE MOLECULAR MECHANISMS OF HZE INDUCED CARCINOGENESIS WE WILL USE A MOUSE MODEL OF HZEINDUCED HEPATOCELLULAR CARCINOMA TO STUDY MICROENVIRONMENT CHANGES AFTER EXPOSURE TO LOW LEVEL HZE. A COMPREHENSIVE SYSTEMS BIOLOGY APPROACH CONSISTING OF TRANSCRIPTOMICS, LIPIDOMICS, PROTEOMICS AND METABOLOMICS WITH NOVEL DATA ANALYSIS WILL BE USED TO BUILD DETAILED BIOLOGICAL PATHWAYS AND IDENTIFY MOLECULAR MECHANISMS THAT DRIVE CARCINOGENESIS. THIS WORK WILL FURTHER OUR UNDERSTANDING OF RISK AT A MECHANISTIC LEVEL AND ALLOW THE DEVELOPMENT OF NEW MODELS FOR ESTIMATING HUMAN RISK. THIS STAGE 2 PROPOSAL IS A RESUBMISSION OF A PROPOSAL OF THE SAME TITLE SUBMITTED IN 2013 IN RESPONSE TO NASA NRA NNJ13ZSA001N WHICH INCLUDES RESPONSE TO REVIEWER COMMENTS AND ADDITIONAL NOVEL PRELIMINARY DATA ON MICROENVIRONMENTAL CHANGES OBSERVED IN AN HZE-INDUCED HCC MOUSE MODEL.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX15AD65G  
Wednesday, July 20, 2016
$133,748.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
EXPOSURE TO HIGH-ENERGY HEAVY IONS (HZE) DURING SPACE TRAVEL IS A HEALTH RISK FOR ASTRONAUTS. EVEN AT LOW DOSES, EXPOSURE TO HZE CAN LEAD TO CANCER. TO BETTER UNDERSTAND THE MOLECULAR MECHANISMS OF HZE INDUCED CARCINOGENESIS WE WILL USE A MOUSE MODEL OF HZEINDUCED HEPATOCELLULAR CARCINOMA TO STUDY MICROENVIRONMENT CHANGES AFTER EXPOSURE TO LOW LEVEL HZE. A COMPREHENSIVE SYSTEMS BIOLOGY APPROACH CONSISTING OF TRANSCRIPTOMICS, LIPIDOMICS, PROTEOMICS AND METABOLOMICS WITH NOVEL DATA ANALYSIS WILL BE USED TO BUILD DETAILED BIOLOGICAL PATHWAYS AND IDENTIFY MOLECULAR MECHANISMS THAT DRIVE CARCINOGENESIS. THIS WORK WILL FURTHER OUR UNDERSTANDING OF RISK AT A MECHANISTIC LEVEL AND ALLOW THE DEVELOPMENT OF NEW MODELS FOR ESTIMATING HUMAN RISK. THIS STAGE 2 PROPOSAL IS A RESUBMISSION OF A PROPOSAL OF THE SAME TITLE SUBMITTED IN 2013 IN RESPONSE TO NASA NRA NNJ13ZSA001N WHICH INCLUDES RESPONSE TO REVIEWER COMMENTS AND ADDITIONAL NOVEL PRELIMINARY DATA ON MICROENVIRONMENTAL CHANGES OBSERVED IN AN HZE-INDUCED HCC MOUSE MODEL.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX15AD65G  
Friday, July 15, 2016
$50,000.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
DURING DEEP SPACE EXPLORATION, PERSONNEL WILL BE EXPOSED TO LOW-FLUENCES OF DENSELY-IONIZING CHARGED PARTICLES OF INTERMEDIATE AND HIGH ATOMIC NUMBER. FOR A GIVEN DOSE THESE ARE ALMOST CERTAINLY MORE LIKELY TO CAUSE CANCER THAN THE SPARSELY IONIZING TYPES OF RADIATION TYPICALLY ENCOUNTERED ON EARTH, SUCH AS X- AND GAMMA-RAYS. IT IS NOT POSSIBLE TO DETERMINE THE CARCINOGENIC POTENTIAL OF SUCH RADIATIONS DIRECTLY IN ASTRONAUTS, SO IT BECOMES NECESSARY TO RELY ON SURROGATE EXPERIMENTAL SYSTEMS TO PROVIDE THIS INFORMATION. BECAUSE THEY CAUSE CANCER, BECAUSE THEY FOUND IN VIRTUALLY ALL CANCERS, AND BECAUSE THEY RESPOND TO DOSE IN BIOPHYSICALLY PREDICTABLE WAYS, THE FORMATION NONLETHAL (TRANSMISSIBLE) CHROMOSOME ABERRATIONS REPRESENTS AN EXCELLENT SURROGATE MODEL TO STUDY RADIATION CARCINOGENESIS. AND YET, ONLY RECENTLY HAVE WE BEGUN TO REALLY UNDERSTAND THE MOLECULAR PROCESSES GOVERNING ABERRATION FORMATION, INCLUDING DIFFERENCES THAT PROBABLY EXIST IN THE WAY THAT THEY ARE PRODUCED BY SPARSELY- VERSUS DENSELY-IONIZING RADIATIONS. WE PROPOSE USING WHOLE GENOME SEQUENCING TO CHARACTERIZE STRUCTURAL CHANGES TO THE DNA OF NORMAL HUMAN CELLS THAT ACCOMPANY THE FORMATION OF TRANSMISSIBLE CHROMOSOME ABERRATIONS. WE FOCUS OUR STUDY ON PORTIONS OF THE GCR SPECTRA THAT ARE LIKELY TO BE ENCOUNTERED IN DEEP SPACE, AND WHICH WE HYPOTHESIZE WILL ELICIT DIFFERENT BIOLOGICAL RESPONSES AT THE DNA LEVEL.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX15AG74G  
Thursday, July 7, 2016
$50,000.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
DURING DEEP SPACE EXPLORATION, PERSONNEL WILL BE EXPOSED TO LOW-FLUENCES OF DENSELY-IONIZING CHARGED PARTICLES OF INTERMEDIATE AND HIGH ATOMIC NUMBER. FOR A GIVEN DOSE THESE ARE ALMOST CERTAINLY MORE LIKELY TO CAUSE CANCER THAN THE SPARSELY IONIZING TYPES OF RADIATION TYPICALLY ENCOUNTERED ON EARTH, SUCH AS X- AND GAMMA-RAYS. IT IS NOT POSSIBLE TO DETERMINE THE CARCINOGENIC POTENTIAL OF SUCH RADIATIONS DIRECTLY IN ASTRONAUTS, SO IT BECOMES NECESSARY TO RELY ON SURROGATE EXPERIMENTAL SYSTEMS TO PROVIDE THIS INFORMATION. BECAUSE THEY CAUSE CANCER, BECAUSE THEY FOUND IN VIRTUALLY ALL CANCERS, AND BECAUSE THEY RESPOND TO DOSE IN BIOPHYSICALLY PREDICTABLE WAYS, THE FORMATION NONLETHAL (TRANSMISSIBLE) CHROMOSOME ABERRATIONS REPRESENTS AN EXCELLENT SURROGATE MODEL TO STUDY RADIATION CARCINOGENESIS. AND YET, ONLY RECENTLY HAVE WE BEGUN TO REALLY UNDERSTAND THE MOLECULAR PROCESSES GOVERNING ABERRATION FORMATION, INCLUDING DIFFERENCES THAT PROBABLY EXIST IN THE WAY THAT THEY ARE PRODUCED BY SPARSELY- VERSUS DENSELY-IONIZING RADIATIONS. WE PROPOSE USING WHOLE GENOME SEQUENCING TO CHARACTERIZE STRUCTURAL CHANGES TO THE DNA OF NORMAL HUMAN CELLS THAT ACCOMPANY THE FORMATION OF TRANSMISSIBLE CHROMOSOME ABERRATIONS. WE FOCUS OUR STUDY ON PORTIONS OF THE GCR SPECTRA THAT ARE LIKELY TO BE ENCOUNTERED IN DEEP SPACE, AND WHICH WE HYPOTHESIZE WILL ELICIT DIFFERENT BIOLOGICAL RESPONSES AT THE DNA LEVEL.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX15AG74G  
Thursday, June 9, 2016
$701,677.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
IGF::OT::IGF UTMB, ANIMALS MODEL OF INFECTIOUS DISEASE, TASK A74
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200010     HHSN272201000040I  
Thursday, June 2, 2016
$148,660.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
IGF::OT::IGF OTHER FUNCTIONS - TASK A71, "EVALUATION OF THERAPEUTICS AND VACCINES IN MOUSE MODELS OF DENGUE VIRUS."
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200009     HHSN272201000040I  
Tuesday, May 31, 2016
$0.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
IGF::OT::IGF OTHER FUNCTIONS - THE PURPOSE OF THIS MODIFICATION IS TO: (1) EXERCISE OPTION 5A IN THE AMOUNT OF $254,802; (2) UPDATE THE COMPLETION PERIOD IN ARTICLE F.1; (3) CHANGE THE PRINCIPAL INVESTIGATOR TO DR. DAVID BEASLEY IN ARTICLE G.2; AND (4) UPDATE THE TASK ORDER CLAUSES IN ARTICLE I.1.
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200009     HHSN272201000040I  
Tuesday, May 31, 2016
$50,000.00
1200: Department of Agriculture
126395: USDA APHIS MRPBS

A: BPA CALL
IGF::OT::IGF UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON WILL TEST CERVID SAMPLES FOR 5 ARBOVIRUSES INCLUDING (1) LACROSSE VIRUS, (2) BLUETONGUE VIRUS, (3) EASTERN EQUINE ENCEPHALITIS,(4) ST. LOUIS ENCEPHALITIS, AND (5) POWASSAN OR DEER TICK VIRUS
Q301: MEDICAL- LABORATORY TESTING

  AG6395K160267     AG6395B160061  
Wednesday, May 25, 2016
$49,167.00
9700: Department of Defense
N0622A: NAVY MEDICINE PROFESSIONAL

C: DELIVERY ORDER
IGF::OT::IGF TUITION AND FEES
U005: EDUCATION/TRAINING- TUITION/REGISTRATION/MEMBERSHIP FEES

  8E44     N0014098G2541  
Thursday, May 19, 2016
($2,275.49)
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
THE GOAL OF THIS NSCOR IS TO PROVIDE THE INFORMATION REQUIRED TO DEVELOP A RATIONAL SCIENTIFIC BASIS FOR ESTIMATION OF RISKS FOR CARCINOGENESIS IN HUMANS FROM EXPOSURE TO RADIATION DURING SPACE FLIGHT. PREVIOUS RESULTS FROM THIS PROGRAM FOUND AN UNEXPECTEDLY LOW RBE VALUE FOR ACUTE MYELOID LEUKEMIA (AML) INDUCTION BY 1 GEV 56FE IONS. SYSTEMATIC CYTOGENETIC ANALYSES SUGGESTED BOTH MICRODOSIMETRIC FACTORS RELATED TO THE TRACK STRUCTURE OF 1 GEV 56FE IONS AND BIOLOGICAL FACTORS COULD ACCOUNT FOR THIS OBSERVATION. IN ADDITION - THESE STUDIES FOUND AN UNEXPECTED INCREASE IN HEPATOCELLULAR CARCINOMA (HCC) AT DOSES AS LOW AS 0.1 GY OF 1 GEV 56FE IONS BUT VERY LITTLE - IF ANY - INCREASE FOLLOWING GAMMA-RAY EXPOSURE. THESE DATA SUGGEST THAT PROCESSES ASSOCIATED WITH EXPANSION AND PROGRESSION OF INITIATED CELLS MAY PLAY A MORE PROMINENT ROLE IN HCC. IF THIS IS THE CASE - IT IS POSSIBLE THAT THERE ARE QUALITATIVE DIFFERENCES AS WELL AS QUANTITATIVE IN THE EFFECTS OF HZE IRRADIATIONS. TO EXPAND ON THESE RESULTS AND TO ADDRESS THE OVERALL GOAL OF THIS NSCOR A SERIES OF COORDINATED ACTIVITIES WILL CONDUCTED IN 5 PROJECTS AND 3 CORES AIMED AT: (1) PROVIDING QUANTITATIVE ANIMAL TUMORIGENESIS DATA ON THE RELATIVE EFFECTIVENESS OF SPECIFIC HZE PARTICLES AND SPE PROTONS COMPARED WITH GAMMA-RAYS IN MOUSE MODELS OF AML AND HCC; (2) PROVIDING A BETTER UNDERSTANDING OF THE IMPACT OF RADIATION EXPOSURE ON THE PROCESSES INVOLVED IN THE INITIATION AND IN THE PROGRESSION OF INITIATED CELLS TOWARD THE NEOPLASTIC PHENOTYPE; 3) DELINEATING POTENTIAL DIFFERENCES BETWEEN LOW LET RADIATION AND HIGH LET RADIATION SUCH AS THOSE ENCOUNTERED IN SPACE TRAVEL ON THESE PROCESSES; 4) DEVELOPING LINKS BETWEEN ANIMAL DATA AND RADIATION-INDUCED EFFECTS FOR AML IN HUMANS; AND (5) DEVELOPING BIOLOGICALLY-BASED MODELING APPROACHES WHICH ARE CRITICAL TO LINK THESE BIOLOGICAL EFFECTS TO RISKS IN HUMANS.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX09AM08G  
Wednesday, May 18, 2016
$75,328.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
THE LONG-TERM GOAL OF THIS PROPOSAL IS TO DETERMINE THE THERAPEUTIC EFFICACY OF TESTOSTERONE AND LEUCINE AT PRESERVING LEAN MUSCLE MASS, MUSCLE STRENGTH, AND BONE MINERAL DENSITY IN HEALTHY HUMANS DURING SPACEFLIGHT. WE PROPOSE TO EXAMINE THE INTERACTIVE OR ADDITIVE EFFECTS OF THE COMBINATION OFTESTOSTERONE OR LEUCINE AND EXERCISE ON LEAN BODY MASS (LBM), MUSCLE STRENGTH AND BONE HEALTH. OUR GENERAL HYPOTHESIS IS THAT THE MAINTENANCE OF NORMAL PHYSIOLOGIC LEVELS OF TESTOSTERONE IN MALES OR INCREASING LEUCINE AVAILABILITY IN FEMALES DURING SPACEFLIGHT WILL PROTECT AGAINST THE FUNCTIONAL LOSS OF MUSCLE AND BONE, AND WILL MAXIMIZE THE EFFICACY OF EXISTING RESISTANCE EXERCISE PROTOCOLS AT PREVENTING OR REVERSING FUNCTIONAL IMPAIRMENTS THAT OCCUR DURING 3 MONTHS OF BED REST IN BOTH MEN AND WOMEN. TO ACHIEVE THESE GOALS WE WILL TEST THE FOLLOWING SPECIFIC HYPOTHESES BEFORE, DURING AND AFTER 90 DAYS OF BED REST: 1) MONTHLY CYCLED TESTOSTERONE REPLACEMENT (DAILY TESTOSTERONE FOR 1ST MONTH, FOLLOWED BY ONE MONTH OFF, ETC.) IN CONJUNCTION WITH EXERCISE WILL HAVE AN ADDITIVE EFFECT IN PREVENTING LOSS OF MUSCLE MASS, MUSCLE STRENGTH, BONE MASS, AND MARKERS OF BONE METABOLISM IN MEN REPRESENTATIVE OFTHE ASTRONAUT POPULATION COMPARED TO EXERCISE WITH PLACEBO TESTOSTERONE. 2) DAILY LEUCINE SUPPLEMENTATION (3 X 4G TAKEN WITH MEALS) IN CONJUNCTION WITH EXERCISE WILL HAVE AN ADDITIVE EFFECT IN PREVENTING LOSS OF MUSCLE MASS AND MUSCLE STRENGTH IN WOMEN REPRESENTATIVE OF THE ASTRONAUT POPULATION COMPARED TO EXERCISE WITH PLACEBO LEUCINE. TO ADDRESS THESE HYPOTHESES WE WILL INVESTIGATE THE FOLLOWING SPECIFIC AIMS BEFORE, DURING AND AFTER 90 DAYS OF BED REST: SPECIFIC AIM LA: TO DETERMINE THE EFFECT OF MONTHLY CYCLED TESTOSTERONE REPLACEMENT IN CONJUNCTION WITH RESISTANCE EXERCISE ON MUSCLE MASS, MUSCLE STRENGTH, BONE MASS AND MARKERS OF BONE METABOLISM IN MEN AGED 35-55. SPECIFIC AIM 2B: TO DETERMINE THE EFFECT OF DAILY LEUCINE SUPPLEMENTATION IN CONJUNCTION WITH RESISTANCE EXERCISE ON MUSCLE MASS AND MUSCLE STRENGTH, BONE MASS, AND MARKERS OF BONE METABOLISM IN WOMEN AGED 35-55. CURRENT EVIDENCE SUGGESTS THAT THE COMBINATION OF TESTOSTERONE, AMINO ACIDS, AND EXERCISE WILL OPTIMIZE THE EFFECTIVENESS OF THE EXISTING EXERCISE AND NUTRITIONAL COUNTERMEASURES. RESULTS FROM THIS PROPOSAL WILL LAY THE GROUND WORK FOR THE IMPLEMENTATION OF COMBINATIONAL COUNTERMEASURES THAT WILL ADDITIVELY WORK TO MAINTAIN PREFLIGHT PHYSIOLOGY OF FEMALE AND MALE ASTRONAUTS DURING LONG-TERM SPACEFLIGHT MISSIONS.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX10AP86G  
Tuesday, May 17, 2016
$0.00
1200: Department of Agriculture
126395: USDA APHIS MRPBS

E: BPA
IGF::OT::IGF BPA TO FACILITATE THE PURCHASE OF LAB TESTING FROM THE UNIVERSITY OF TEXAS GALVESTON NATIONAL LABORATORY (GNL) FOR CERVID ARBOVIRUS TESTING.
Q301: MEDICAL- LABORATORY TESTING

  AG6395B160061  
Monday, May 9, 2016
$0.00
7500: Department of Health and Human Services
75A501: OFFICE OF ACQ MGMT POLICY

B: IDC
UTMB - DEVELOPMENT OF ANIMAL MODELS TO MEET THE THREATS OF CBRN AGENTS, INFLUENZA, AND EMERGING INFECTIOUS DISEASES IN SUPPORT OF THE PREPAREDNESS MISSION
AN13: R&D- MEDICAL: BIOMEDICAL (ADVANCED DEVELOPMENT)

  HHSO100201100015I     10100SOL00025  
Monday, May 9, 2016
($22.73)
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
THIS IS A STEP-2 PROPOSAL FROM A TEAM OF INVESTIGATORS FROM THE UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON, TX, IN RESPONSE TO NASA BION-ML PROJECT NRA NNH07ZTTOOIN. OUR OVERARCHING HYPOTHESIS IS THAT COMBINATION OF SEVERAL FACTORS FROM MICROGRAVITY TO STRESS, AFFECT THE HUMAN IMMUNE SYSTEM DURING SPACE FLIGHT RESULTING IN IMPAIRED HOST RESPONSE AGAINST VIRAL RESPIRATORY PATHOGENS. THE MOST PREVALENT ACUTE RESPIRATORY TRACT ILLNESSES IN THE GENERAL COMMUNITY ARE MOSTLY BENIGN, SELF-LIMITING EVENTS FOLLOWING PRIMARILY INFECTIONS OF THE UPPER RESPIRATORY TRACT (URTI). ALTHOUGH THE FACTORS THAT CONTRIBUTE TO THE PROGRESSION OF URTI TO SEVERE LOWER RESPIRATORY TRACT ILLNESS ARE NOT FULLY UNDERSTOOD, A ROBUST INNATE IMMUNE RESPONSE APPEARS TO BE CRITICAL FOR LIMITING DISEASE, BLOCKING VIRAL SHEDDING AND PERSON-TO-PERSON TRANSMISSION. TWO KEY ELEMENTS OF THE INNATE IMMUNE SYSTEM, IFN TYPE I AND DENDRITIC CELLS, HAVE BEEN REPORTED TO BE EITHER SEVERELY IMPAIRED AFTER SPACE FLIGHT OR HAVE NOT BEEN STUDIED SO FAR. BASED ON THE ABOVE STATED HYPOTHESIS WE PROPOSE A TWO-PHASE STUDY WHICH INCLUDES AN INITIAL 2-YEAR PHASE TO REFINE AN EXPERIMENTAL MODEL USING GROUND-BASED MICE IN ANTIORTHOSTATIC SUSPENSION THAT WILL BE INFECTED WITH TWO MAJOR HUMAN RESPIRATORY PATHOGENS, RESPIRATORY SYNCYTIAL VIRUS (RSV) AND HUMAN METAPNEUMOVIRUS (HMPV). THE SECOND PHASE (POST-MISSION) (DURATION 1-2 YEARS) WILL START WITH INFECTION OF A GROUP OF MICE FLOWN ONBOARD THE BION-ML SPACECRAFT, COLLECTION OF EXTENSIVE CLINICAL, VIROLOGIC AND IMMUNOLOGIC DATA, AND COMPARISON WITH DATA COLLECTED IN GROUND-BASED ANIMAL MODELS. OVERALL, THESE INVESTIGATIONS ARE LIKELY TO GENERATE NEW CRITICAL SCIENTIFIC EVIDENCE OF THE IMMUNE PATHWAYS THAT ARE AFFECTED IN ANTIVIRAL HOST RESPONSE DURING SPACE FLIGHT AND POSSIBLE PREVENTIVE OR THERAPEUTIC APPROACHES APPLICABLE TO FUTURE SPACE MISSIONS.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX10AI50G  
Wednesday, April 27, 2016
$452.96
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

F: COOPERATIVE AGREEMENT
THIS PROPOSAL ENCOMPASSES A WIDE RANGE OF EDUCATIONAL TRAINING OPPORTUNITIES TO SUPPORT NASA'S MISSION AND TO MEET THE EDUCATIONAL NEEDS OF NASA PHYSICIANS. THE AREAS INCLUDE GRADUATE MEDICAL EDUCATION TRAINING AND CONTINUING MEDICAL EDUCATION (CME). THE TRAINING REQUIREMENTS FOR A SPACE MEDICINE OPERATIONAL PROVIDER ARE UNIQUE. AS PARTNERS IN THIS SPACE MEDICINE FOCUSED RESIDENCY PROGRAM, NASA AND UTMB HAVE A 16 YEAR TRACK RECORD OF SUCCESSFULLY SELECTING AND TRAINING OUTSTANDING PHYSICIANS WHO PROGRESS TO ACTIVE SUPPORT OF NASA AND MEET NEEDS OF THE U.S. SPACE PROGRAM. NOT ONLY ARE THE RESIDENTS TRAINED FOR SPACE MEDICINE SUPPORT AT NASA, THEY ALSO COMPLETE THE CORE COMPETENCIES LEADING TO CERTIFICATION IN AEROSPACE MEDICINE BY THE AMERICAN BOARD OF PREVENTIVE MEDICINE AND ACCREDITATION COUNCIL ON GRADUATE MEDICAL EDUCATION. WE HAVE ALSO PACKAGED GRADUATE COURSES AS PART OF THE CEPH APPROVED MPH IN AEROSPACE MEDICINE AND PRACTICUM COURSES/ACTIVITIES THAT ARE ESSENTIAL TO AEROSPACE MEDICINE PRACTITIONERS AND OUR AREA OF SPECIFIC EMPHASIS, SPACE MEDICINE. NO OTHER ACADEMIC INSTITUTION PROVIDES ACADEMIC AND PRACTICUM ACTIVITIES SO CLOSELY TIED TO MEDICAL OPERATIONS AND SCIENCE IN THE SPACE PROGRAM. UTMB ALSO MAINTAINS AFFILIATION AGREEMENTS WITH MILITARY AVIATION-RELATED INSTITUTIONS SUCH AS BROOKS CITY BASE, NAS PENSACOLA, AND THE FAA CIVIL AEROSPACE MEDICAL INSTITUTE THAT BENEFIT NASA AND THE MILITARY AND CIVILIAN CREWMEMBERS THESE PHYSICIANS EVENTUALLY SUPPORT. RESIDENTS ARE TRAINED IN ALL ASPECTS OF AEROSPACE MEDICINE AND ARE ABLE TO FUNCTION IN ENVIRONMENTS AS DIVERSE AS GENERAL AVIATION, COMMERCIAL AVIATION, SPACE FLIGHT, AND IN GOVERNMENTAL AND ACADEMIC INSTITUTIONS. IN PREPARATION FOR FUTURE INCREASED COOPERATION WITH THE COMMERCIAL SPACEFLIGHT INDUSTRY, RESIDENTS ARE GIVEN EXPERIENCE IN THIS FIELD WHEN OPPORTUNITIES ARE AVAILABLE. AS PART OF THE EDUCATIONAL ACTIVITIES FOR THE RESIDENTS, SESSIONS SUCH AS AEROSPACE MEDICINE GRAND ROUNDS AND JOURNAL CLUB ARE AVAILABLE LOCALLY AND BY TELECONFERENCING WITH THE PHYSICIANS AT ALL THE NASA CENTERS. THIS ALLOWS THEM TO IMPROVE THEIR CLINICAL AND ACADEMIC SKILLS AND MEET THE CME REQUIREMENT OF THEIR STATE LICENSING BOARDS. THE GRADUATES OF THE AEROSPACE MEDICINE RESIDENCY PROGRAM ARE IN DEMAND, AND WE PREDICT THIS DEMAND TO CONTINUE THROUGH THE LIFE CYCLE OF THE ISS. TO DATE, 24 OF THE SPACE-TRACK PHYSICIAN GRADUATES OF THE PROGRAM HAVE BEEN EMPLOYED BY NASA OR ONE OF NASA'S PRIMARY CONTRACTORS. UNLIKE MANY NEW HIRES IN THE SPACE PROGRAM, OUR TRAINING PARTNERSHIP PRODUCES GRADUATES THAT ARE IMMEDIATELY PRODUCTIVE WHEN HIRED. NASA AND UTMB HAVE A UNIQUE OPPORTUNITY TO CONTINUE THIS PRODUCTIVE PARTNERSHIP TO TRAIN THE NEXT GENERATION OF SPACE MEDICINE PHYSICIANS. WE PROPOSE TO CONTINUE PRODUCING TWO-THREE RESIDENT GRADUATES PER YEAR IN THE SPACE MEDICINE TRACK. TO THIS END WE ARE REQUESTING NASA'S CONTINUED FINANCIAL SUPPORT FOR GRADUATE MEDICAL EDUCATION TRAINING IN AEROSPACE MEDICINE. IN ORDER TO FACILITATE LONG TERM PLANNING, WE ARE SEEKING A NEW FIVE YEAR COOPERATIVE AGREEMENT.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX10AT57A  
Monday, April 25, 2016
$824,854.00
7500: Department of Health and Human Services
75N97A: NATIONAL INSTITUTES OF HEALTH CIT

C: DELIVERY ORDER
IGF::OT::IGF UTMB, ANIMALS MODEL OF INFECTIOUS DISEASE,TESTING OF MICE FOR EBOLA A94
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200011     HHSN272201000040I  
Monday, April 11, 2016
($49,481.56)
8000: National Aeronautics and Space Administration
80JSC0: NASA JOHNSON SPACE CENTER

B: PURCHASE ORDER
IGF::OT::IGF BED REST STUDIES INFRASTRUCTURE AND SERVICES
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  NNJ15HP01P     NNJ15531109R  
Friday, April 1, 2016
$153,379.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

C: DELIVERY ORDER
IGF::OT::IGF - TITLE_ANIMAL MODELS OF INFECTIOUS DISEASES; TASK A68
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200008     HHSN272201000040I  
Wednesday, March 23, 2016
$196,337.09
8000: National Aeronautics and Space Administration
NSSC0: NASA SHARED SERVICES CENTER

F: COOPERATIVE AGREEMENT
THE TRAINING REQUIREMENTS FOR SPACE MEDICINE OPERATIONAL AND RESEARCH PROVIDERS ARE UNIQUE. AS PARTNERS IN THIS SPACE MEDICINE FOCUSED RESIDENCY PROGRAM, NASA AND THE UNIVERSITY OF TEXAS MEDICAL BRANCH (UTMB) HAVE A 21-YEAR TRACK RECORD OF SUCCESSFULLY SELECTING AND TRAINING OUTSTANDING PHYSICIANS WHO PROGRESS TO ACTIVELY SUPPORT NASA AND MEET NEEDS OF THE U.S. SPACE PROGRAM. NOT ONLY ARE THE RESIDENTS TRAINED FOR SPACE MEDICINE SUPPORT AT NASA, THEY ALSO COMPLETE THE CORE COMPETENCIES SET BY THE ACCREDITATION COUNCIL ON GRADUATE MEDICAL EDUCATION (ACGME), LEADING TO CERTIFICATION IN AEROSPACE MEDICINE BY THE AMERICAN BOARD OF PREVENTIVE MEDICINE. UTMB OFFERS GRADUATE COURSES AS PART OF THE APPROVED MASTER OF PUBLIC HEALTH (MPH) WITH AN AEROSPACE MEDICINE TRACK AND PRACTICUM ACTIVITIES. OTHER EDUCATIONAL ACTIVITIES, SUCH AS JOURNAL CLUB AND AEROSPACE GRAND ROUNDS ARE ESSENTIAL TO SPACE MEDICINE PRACTITIONERS, AND ARE AVAILABLE LOCALLY AND REMOTELY FOR PHYSICIANS AT ALL THE NASA CENTERS, SATELLITE LOCATIONS, AND STREAMED LIVE. THIS ALLOWS PRACTICING PHYSICIANS TO TAKE ADVANTAGE OF OPPORTUNITIES TO IMPROVE THEIR CLINICAL AND ACADEMIC SKILLS AND MEET THE CONTINUING MEDICAL EDUCATION (CME) REQUIREMENTS OF STATE LICENSING BOARDS. UTMB ALSO COORDINATES OTHER ACTIVITIES FOR NASA PHYSICIANS AND RESIDENTS, SUCH AS VOLUNTEER SERVICE PROJECTS, PROVIDING MEDICAL SUPPORT FOR THE WINGS OVER HOUSTON AIRSHOW AND THE HOUSTON MARATHON, CME TRAINING SUCH AS ADVANCED CARDIAC LIFE SUPPORT, BASIC LIFE SUPPORT, AND PRE-HOSPITAL TRAUMA LIFE SUPPORT TRAINING, AS WELL AS OPPORTUNITIES FOR ADJUNCT FACULTY APPOINTMENTS, MEDICAL CREDENTIALING, AND TEACHING. NO OTHER ACADEMIC INSTITUTION PROVIDES ACADEMIC AND PRACTICUM ACTIVITIES SO CLOSELY TIED TO MEDICAL OPERATIONS AND SCIENCE SUPPORT IN THE SPACE PROGRAM. UTMB ALSO MAINTAINS AFFILIATION AGREEMENTS WITH MILITARY AND FEDERAL AVIATION-RELATED INSTITUTIONS SUCH AS THE USAF SCHOOL OF AEROSPACE MEDICINE, WRIGHT-PATTERSON AIR FORCE BASE, THE US ARMY SCHOOL OF AVIATION MEDICINE, AND THE FAA CIVIL AEROSPACE MEDICAL INSTITUTE THAT BENEFIT NOT ONLY NASA BUT THE MILITARY AND CIVILIAN CREWMEMBERS THESE PHYSICIANS EVENTUALLY SUPPORT. RESIDENT PHYSICIANS SUPPORTED BY THIS AGREEMENT ARE TRAINED IN ALL ASPECTS OF AEROSPACE MEDICINE, AND UPON GRADUATION ARE ABLE TO FUNCTION IN ENVIRONMENTS AS DIVERSE AS GENERAL AVIATION, COMMERCIAL AVIATION, SPACE FLIGHT, AND IN GOVERNMENTAL AND ACADEMIC INSTITUTIONS. IN PREPARATION FOR FUTURE INCREASED COOPERATION WITH THE COMMERCIAL SPACEFLIGHT INDUSTRY, RESIDENTS ARE GIVEN EXPERIENCE IN THIS ARENA AS WELL. GRADUATES OF THE AEROSPACE MEDICINE RESIDENCY PROGRAM ARE IN DEMAND, AND IT IS PREDICTED THAT THIS DEMAND WILL CONTINUE THROUGH THE LIFE CYCLE OF THE ISS AND ON TO FUTURE EXPLORATION MISSIONS. TO DATE, 30 OF THE 40 PROGRAM'S GRADUATES HAVE BEEN EMPLOYED BY NASA OR ONE OF ITS PRIMARY CONTRACTORS. THE TRAINING PARTNERSHIP PRODUCES GRADUATES THAT ARE IMMEDIATELY PRODUCTIVE WHEN HIRED. NASA AND UTMB HAVE A UNIQUE OPPORTUNITY TO CONTINUE THIS PRODUCTIVE PARTNERSHIP IN TRAINING THE NEXT GENERATION OF SPACE MEDICINE PHYSICIANS TO LEAD THE FIELD IN RESEARCH AND OPERATIONAL SUPPORT. UTMB PROPOSES TO CONTINUE PRODUCING GRADUATES TRAINED AND BOARD ELIGIBLE IN AEROSPACE MEDICINE, WITH AN EMPHASIS IN SPACE. UTMB IS REQUESTING NASA'S CONTINUED FINANCIAL SUPPORT FOR GRADUATE MEDICAL EDUCATION TRAINING IN AEROSPACE MEDICINE. IN ORDER TO FACILITATE LONG TERM PLANNING, UTMB IS SEEKING A NEW FIVE YEAR COOPERATIVE AGREEMENT.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX16AC91A  
Wednesday, March 23, 2016
$118,000.00
8000: National Aeronautics and Space Administration
NSSC0: NASA SHARED SERVICES CENTER

F: COOPERATIVE AGREEMENT
THIS PROPOSAL ENCOMPASSES A WIDE RANGE OF EDUCATIONAL TRAINING OPPORTUNITIES TO SUPPORT NASA'S MISSION AND TO MEET THE EDUCATIONAL NEEDS OF NASA PHYSICIANS. THE AREAS INCLUDE GRADUATE MEDICAL EDUCATION TRAINING AND CONTINUING MEDICAL EDUCATION (CME). THE TRAINING REQUIREMENTS FOR A SPACE MEDICINE OPERATIONAL PROVIDER ARE UNIQUE. AS PARTNERS IN THIS SPACE MEDICINE FOCUSED RESIDENCY PROGRAM, NASA AND UTMB HAVE A 16 YEAR TRACK RECORD OF SUCCESSFULLY SELECTING AND TRAINING OUTSTANDING PHYSICIANS WHO PROGRESS TO ACTIVE SUPPORT OF NASA AND MEET NEEDS OF THE U.S. SPACE PROGRAM. NOT ONLY ARE THE RESIDENTS TRAINED FOR SPACE MEDICINE SUPPORT AT NASA, THEY ALSO COMPLETE THE CORE COMPETENCIES LEADING TO CERTIFICATION IN AEROSPACE MEDICINE BY THE AMERICAN BOARD OF PREVENTIVE MEDICINE AND ACCREDITATION COUNCIL ON GRADUATE MEDICAL EDUCATION. WE HAVE ALSO PACKAGED GRADUATE COURSES AS PART OF THE CEPH APPROVED MPH IN AEROSPACE MEDICINE AND PRACTICUM COURSES/ACTIVITIES THAT ARE ESSENTIAL TO AEROSPACE MEDICINE PRACTITIONERS AND OUR AREA OF SPECIFIC EMPHASIS, SPACE MEDICINE. NO OTHER ACADEMIC INSTITUTION PROVIDES ACADEMIC AND PRACTICUM ACTIVITIES SO CLOSELY TIED TO MEDICAL OPERATIONS AND SCIENCE IN THE SPACE PROGRAM. UTMB ALSO MAINTAINS AFFILIATION AGREEMENTS WITH MILITARY AVIATION-RELATED INSTITUTIONS SUCH AS BROOKS CITY BASE, NAS PENSACOLA, AND THE FAA CIVIL AEROSPACE MEDICAL INSTITUTE THAT BENEFIT NASA AND THE MILITARY AND CIVILIAN CREWMEMBERS THESE PHYSICIANS EVENTUALLY SUPPORT. RESIDENTS ARE TRAINED IN ALL ASPECTS OF AEROSPACE MEDICINE AND ARE ABLE TO FUNCTION IN ENVIRONMENTS AS DIVERSE AS GENERAL AVIATION, COMMERCIAL AVIATION, SPACE FLIGHT, AND IN GOVERNMENTAL AND ACADEMIC INSTITUTIONS. IN PREPARATION FOR FUTURE INCREASED COOPERATION WITH THE COMMERCIAL SPACEFLIGHT INDUSTRY, RESIDENTS ARE GIVEN EXPERIENCE IN THIS FIELD WHEN OPPORTUNITIES ARE AVAILABLE. AS PART OF THE EDUCATIONAL ACTIVITIES FOR THE RESIDENTS, SESSIONS SUCH AS AEROSPACE MEDICINE GRAND ROUNDS AND JOURNAL CLUB ARE AVAILABLE LOCALLY AND BY TELECONFERENCING WITH THE PHYSICIANS AT ALL THE NASA CENTERS. THIS ALLOWS THEM TO IMPROVE THEIR CLINICAL AND ACADEMIC SKILLS AND MEET THE CME REQUIREMENT OF THEIR STATE LICENSING BOARDS. THE GRADUATES OF THE AEROSPACE MEDICINE RESIDENCY PROGRAM ARE IN DEMAND, AND WE PREDICT THIS DEMAND TO CONTINUE THROUGH THE LIFE CYCLE OF THE ISS. TO DATE, 24 OF THE SPACE-TRACK PHYSICIAN GRADUATES OF THE PROGRAM HAVE BEEN EMPLOYED BY NASA OR ONE OF NASA'S PRIMARY CONTRACTORS. UNLIKE MANY NEW HIRES IN THE SPACE PROGRAM, OUR TRAINING PARTNERSHIP PRODUCES GRADUATES THAT ARE IMMEDIATELY PRODUCTIVE WHEN HIRED. NASA AND UTMB HAVE A UNIQUE OPPORTUNITY TO CONTINUE THIS PRODUCTIVE PARTNERSHIP TO TRAIN THE NEXT GENERATION OF SPACE MEDICINE PHYSICIANS. WE PROPOSE TO CONTINUE PRODUCING TWO-THREE RESIDENT GRADUATES PER YEAR IN THE SPACE MEDICINE TRACK. TO THIS END WE ARE REQUESTING NASA'S CONTINUED FINANCIAL SUPPORT FOR GRADUATE MEDICAL EDUCATION TRAINING IN AEROSPACE MEDICINE. IN ORDER TO FACILITATE LONG TERM PLANNING, WE ARE SEEKING A NEW FIVE YEAR COOPERATIVE AGREEMENT.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX10AT57A  
Monday, March 14, 2016
$254,802.00
7500: Department of Health and Human Services
00272: NIH, NIAID DEA OA OFC ACQUISITIONS

C: DELIVERY ORDER
IGF::OT::IGF OTHER FUNCTIONS - THE PURPOSE OF THIS MODIFICATION IS TO: (1) EXERCISE OPTION 5A IN THE AMOUNT OF $254,802; (2) UPDATE THE COMPLETION PERIOD IN ARTICLE F.1; (3) CHANGE THE PRINCIPAL INVESTIGATOR TO DR. DAVID BEASLEY IN ARTICLE G.2; AND (4) UPDATE THE TASK ORDER CLAUSES IN ARTICLE I.1.
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200009     HHSN272201000040I  
Friday, March 11, 2016
$53,000.00
8000: National Aeronautics and Space Administration
NSSC0: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
THE LONG-TERM GOAL OF THIS PROPOSAL IS TO DETERMINE THE THERAPEUTIC EFFICACY OF TESTOSTERONE AND LEUCINE AT PRESERVING LEAN MUSCLE MASS, MUSCLE STRENGTH, AND BONE MINERAL DENSITY IN HEALTHY HUMANS DURING SPACEFLIGHT. WE PROPOSE TO EXAMINE THE INTERACTIVE OR ADDITIVE EFFECTS OF THE COMBINATION OFTESTOSTERONE OR LEUCINE AND EXERCISE ON LEAN BODY MASS (LBM), MUSCLE STRENGTH AND BONE HEALTH. OUR GENERAL HYPOTHESIS IS THAT THE MAINTENANCE OF NORMAL PHYSIOLOGIC LEVELS OF TESTOSTERONE IN MALES OR INCREASING LEUCINE AVAILABILITY IN FEMALES DURING SPACEFLIGHT WILL PROTECT AGAINST THE FUNCTIONAL LOSS OF MUSCLE AND BONE, AND WILL MAXIMIZE THE EFFICACY OF EXISTING RESISTANCE EXERCISE PROTOCOLS AT PREVENTING OR REVERSING FUNCTIONAL IMPAIRMENTS THAT OCCUR DURING 3 MONTHS OF BED REST IN BOTH MEN AND WOMEN. TO ACHIEVE THESE GOALS WE WILL TEST THE FOLLOWING SPECIFIC HYPOTHESES BEFORE, DURING AND AFTER 90 DAYS OF BED REST: 1) MONTHLY CYCLED TESTOSTERONE REPLACEMENT (DAILY TESTOSTERONE FOR 1ST MONTH, FOLLOWED BY ONE MONTH OFF, ETC.) IN CONJUNCTION WITH EXERCISE WILL HAVE AN ADDITIVE EFFECT IN PREVENTING LOSS OF MUSCLE MASS, MUSCLE STRENGTH, BONE MASS, AND MARKERS OF BONE METABOLISM IN MEN REPRESENTATIVE OFTHE ASTRONAUT POPULATION COMPARED TO EXERCISE WITH PLACEBO TESTOSTERONE. 2) DAILY LEUCINE SUPPLEMENTATION (3 X 4G TAKEN WITH MEALS) IN CONJUNCTION WITH EXERCISE WILL HAVE AN ADDITIVE EFFECT IN PREVENTING LOSS OF MUSCLE MASS AND MUSCLE STRENGTH IN WOMEN REPRESENTATIVE OF THE ASTRONAUT POPULATION COMPARED TO EXERCISE WITH PLACEBO LEUCINE. TO ADDRESS THESE HYPOTHESES WE WILL INVESTIGATE THE FOLLOWING SPECIFIC AIMS BEFORE, DURING AND AFTER 90 DAYS OF BED REST: SPECIFIC AIM LA: TO DETERMINE THE EFFECT OF MONTHLY CYCLED TESTOSTERONE REPLACEMENT IN CONJUNCTION WITH RESISTANCE EXERCISE ON MUSCLE MASS, MUSCLE STRENGTH, BONE MASS AND MARKERS OF BONE METABOLISM IN MEN AGED 35-55. SPECIFIC AIM 2B: TO DETERMINE THE EFFECT OF DAILY LEUCINE SUPPLEMENTATION IN CONJUNCTION WITH RESISTANCE EXERCISE ON MUSCLE MASS AND MUSCLE STRENGTH, BONE MASS, AND MARKERS OF BONE METABOLISM IN WOMEN AGED 35-55. CURRENT EVIDENCE SUGGESTS THAT THE COMBINATION OF TESTOSTERONE, AMINO ACIDS, AND EXERCISE WILL OPTIMIZE THE EFFECTIVENESS OF THE EXISTING EXERCISE AND NUTRITIONAL COUNTERMEASURES. RESULTS FROM THIS PROPOSAL WILL LAY THE GROUND WORK FOR THE IMPLEMENTATION OF COMBINATIONAL COUNTERMEASURES THAT WILL ADDITIVELY WORK TO MAINTAIN PREFLIGHT PHYSIOLOGY OF FEMALE AND MALE ASTRONAUTS DURING LONG-TERM SPACEFLIGHT MISSIONS.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX10AP86G  
Wednesday, February 17, 2016
$0.00
7500: Department of Health and Human Services
00272: NIH, NIAID DEA OA OFC ACQUISITIONS

C: DELIVERY ORDER
IGF::OT::IGF THE PURPOSE OF THIS MODIFICATION IS TO CHANGE ATTACHMENT 3 - DELIVERY SCHEDULE IN SECTION J.
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200008     HHSN272201000040I  
Friday, February 12, 2016
$163,322.00
8000: National Aeronautics and Space Administration
NSSC0: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
HIGHLY ENERGETIC HEAVY IONS (HZE), OF THE TYPE FOUND IN GALACTIC COSMIC RAYS, DEPOSIT ENERGY IN CLOSELY SPACED AREAS ALONG THE PATHS (TRACKS) THESE IONS TAKE AS THEY PASS THROUGH CELLS. THIS TIGHT SPACING MAKES THESE PARTICLES PARTICULARLY DAMAGING TO IMPORTANT CELLULAR COMPONENTS SUCH AS CHROMOSOMES. SOME OF THE ENERGY OF THE HZE PARTICLE CAN BE TRANSFERRED TO ELECTRONS (DELTA RAYS) WHICH CAN TRAVEL RELATIVELY LONG DISTANCES AND PRODUCE DAMAGE IN CELLS FAR REMOVED FROM THE ORIGINAL PARTICLE TRACK. THE CELL HAS MECHANISMS THAT CAN REJOIN BROKEN CHROMOSOMES BUT THESE PROCESSES CAN MAKE MISTAKES CAUSING SEGMENTS OF THE CHROMOSOMES INVOLVED TO EXCHANGE. IT IS OUR HYPOTHESIS THAT DAMAGE PRODUCED BY DELTA RAYS FROM HZE PARTICLE TRACKS CAN INTERACT WITH DAMAGE NEAR THE CENTER OF AN INDEPENDENT PARTICLE TRACK AND ADD MORE BREAKS TO AN EXCHANGE THAT MIGHT BE FORMING CLOSE TO THE CENTER OF THE SECOND TRACK. SUCH INTERACTIONS WILL ADD CURVATURE TO THE CHROMOSOME EXCHANGE BREAKPOINT DOSE RESPONSE. WE PLAN TO TEST THIS HYPOTHESIS BY IRRADIATING HUMAN FIBROBLASTS AND LYMPHOCYTES WITH PARTICLES OF DIFFERENT ENERGY CHOSEN IN SUCH A WAY THAT THEY DEPOSIT THE SAME AMOUNT OF ENERGY ALONG A SPECIFIC LENGTH OF THEIR TRACK AND MEASURE THE RESULTING CHROMOSOME EXCHANGES. THE ENERGY IMPARTED TO THE DELTA RAYS WILL BE PROPORTIONAL TO THE ENERGY OF THE HZE PARTICLE SO THAT THE DELTA RAYS FROM A HIGHER ENERGY PARTICLE CAN POTENTIALLY TRAVEL LONGER DISTANCES. THIS SUGGESTS TO US THAT THEY MAY BE ABLE TO ADD MORE BREAKS TO EXCHANGES AND INCREASE THE CURVATURE OF THE DOSE RESPONSE. CHROMOSOME ABERRATIONS ARE IMPORTANT CHANGES IN CELLS THOUGHT TO BE CAUSATIVE OR DIAGNOSTIC OF RADIATION CARCINOGENESIS. A BETTER UNDERSTANDING OF THE MECHANISMS OF THEIR FORMATION WILL REDUCE UNCERTAINTIES IN MODELS USED BY NASA TO DESIGN SPACECRAFT BETTER ABLE TO PROTECT ASTRONAUTS FROM RADIATION.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX14AC76G  
Friday, January 29, 2016
$0.00
7500: Department of Health and Human Services
00272: NIH, NIAID DEA OA OFC ACQUISITIONS

C: DELIVERY ORDER
OTHER FUNCTION: THE PURPOSE OF THIS MODIFICATION IS TO EXTEND THE COMPLETION DATE FOR OPTION 1 PERIOD AT NO ADDITIONAL COST TO THE GOVERNMENT.
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200003     HHSN272201000040I  
Thursday, January 28, 2016
$24,390.20
8000: National Aeronautics and Space Administration
NSSC0: NASA SHARED SERVICES CENTER

F: COOPERATIVE AGREEMENT
THE TRAINING REQUIREMENTS FOR SPACE MEDICINE OPERATIONAL AND RESEARCH PROVIDERS ARE UNIQUE. AS PARTNERS IN THIS SPACE MEDICINE FOCUSED RESIDENCY PROGRAM, NASA AND THE UNIVERSITY OF TEXAS MEDICAL BRANCH (UTMB) HAVE A 21-YEAR TRACK RECORD OF SUCCESSFULLY SELECTING AND TRAINING OUTSTANDING PHYSICIANS WHO PROGRESS TO ACTIVELY SUPPORT NASA AND MEET NEEDS OF THE U.S. SPACE PROGRAM. NOT ONLY ARE THE RESIDENTS TRAINED FOR SPACE MEDICINE SUPPORT AT NASA, THEY ALSO COMPLETE THE CORE COMPETENCIES SET BY THE ACCREDITATION COUNCIL ON GRADUATE MEDICAL EDUCATION (ACGME), LEADING TO CERTIFICATION IN AEROSPACE MEDICINE BY THE AMERICAN BOARD OF PREVENTIVE MEDICINE. UTMB OFFERS GRADUATE COURSES AS PART OF THE APPROVED MASTER OF PUBLIC HEALTH (MPH) WITH AN AEROSPACE MEDICINE TRACK AND PRACTICUM ACTIVITIES. OTHER EDUCATIONAL ACTIVITIES, SUCH AS JOURNAL CLUB AND AEROSPACE GRAND ROUNDS ARE ESSENTIAL TO SPACE MEDICINE PRACTITIONERS, AND ARE AVAILABLE LOCALLY AND REMOTELY FOR PHYSICIANS AT ALL THE NASA CENTERS, SATELLITE LOCATIONS, AND STREAMED LIVE. THIS ALLOWS PRACTICING PHYSICIANS TO TAKE ADVANTAGE OF OPPORTUNITIES TO IMPROVE THEIR CLINICAL AND ACADEMIC SKILLS AND MEET THE CONTINUING MEDICAL EDUCATION (CME) REQUIREMENTS OF STATE LICENSING BOARDS. UTMB ALSO COORDINATES OTHER ACTIVITIES FOR NASA PHYSICIANS AND RESIDENTS, SUCH AS VOLUNTEER SERVICE PROJECTS, PROVIDING MEDICAL SUPPORT FOR THE WINGS OVER HOUSTON AIRSHOW AND THE HOUSTON MARATHON, CME TRAINING SUCH AS ADVANCED CARDIAC LIFE SUPPORT, BASIC LIFE SUPPORT, AND PRE-HOSPITAL TRAUMA LIFE SUPPORT TRAINING, AS WELL AS OPPORTUNITIES FOR ADJUNCT FACULTY APPOINTMENTS, MEDICAL CREDENTIALING, AND TEACHING. NO OTHER ACADEMIC INSTITUTION PROVIDES ACADEMIC AND PRACTICUM ACTIVITIES SO CLOSELY TIED TO MEDICAL OPERATIONS AND SCIENCE SUPPORT IN THE SPACE PROGRAM. UTMB ALSO MAINTAINS AFFILIATION AGREEMENTS WITH MILITARY AND FEDERAL AVIATION-RELATED INSTITUTIONS SUCH AS THE USAF SCHOOL OF AEROSPACE MEDICINE, WRIGHT-PATTERSON AIR FORCE BASE, THE US ARMY SCHOOL OF AVIATION MEDICINE, AND THE FAA CIVIL AEROSPACE MEDICAL INSTITUTE THAT BENEFIT NOT ONLY NASA BUT THE MILITARY AND CIVILIAN CREWMEMBERS THESE PHYSICIANS EVENTUALLY SUPPORT. RESIDENT PHYSICIANS SUPPORTED BY THIS AGREEMENT ARE TRAINED IN ALL ASPECTS OF AEROSPACE MEDICINE, AND UPON GRADUATION ARE ABLE TO FUNCTION IN ENVIRONMENTS AS DIVERSE AS GENERAL AVIATION, COMMERCIAL AVIATION, SPACE FLIGHT, AND IN GOVERNMENTAL AND ACADEMIC INSTITUTIONS. IN PREPARATION FOR FUTURE INCREASED COOPERATION WITH THE COMMERCIAL SPACEFLIGHT INDUSTRY, RESIDENTS ARE GIVEN EXPERIENCE IN THIS ARENA AS WELL. GRADUATES OF THE AEROSPACE MEDICINE RESIDENCY PROGRAM ARE IN DEMAND, AND IT IS PREDICTED THAT THIS DEMAND WILL CONTINUE THROUGH THE LIFE CYCLE OF THE ISS AND ON TO FUTURE EXPLORATION MISSIONS. TO DATE, 30 OF THE 40 PROGRAM'S GRADUATES HAVE BEEN EMPLOYED BY NASA OR ONE OF ITS PRIMARY CONTRACTORS. THE TRAINING PARTNERSHIP PRODUCES GRADUATES THAT ARE IMMEDIATELY PRODUCTIVE WHEN HIRED. NASA AND UTMB HAVE A UNIQUE OPPORTUNITY TO CONTINUE THIS PRODUCTIVE PARTNERSHIP IN TRAINING THE NEXT GENERATION OF SPACE MEDICINE PHYSICIANS TO LEAD THE FIELD IN RESEARCH AND OPERATIONAL SUPPORT. UTMB PROPOSES TO CONTINUE PRODUCING GRADUATES TRAINED AND BOARD ELIGIBLE IN AEROSPACE MEDICINE, WITH AN EMPHASIS IN SPACE. UTMB IS REQUESTING NASA'S CONTINUED FINANCIAL SUPPORT FOR GRADUATE MEDICAL EDUCATION TRAINING IN AEROSPACE MEDICINE. IN ORDER TO FACILITATE LONG TERM PLANNING, UTMB IS SEEKING A NEW FIVE YEAR COOPERATIVE AGREEMENT.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX16AC91A  
Monday, January 25, 2016
$150,000.00
8000: National Aeronautics and Space Administration
NSSC0: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
DURING DEEP SPACE EXPLORATION, PERSONNEL WILL BE EXPOSED TO LOW-FLUENCES OF DENSELY-IONIZING CHARGED PARTICLES OF INTERMEDIATE AND HIGH ATOMIC NUMBER. FOR A GIVEN DOSE THESE ARE ALMOST CERTAINLY MORE LIKELY TO CAUSE CANCER THAN THE SPARSELY IONIZING TYPES OF RADIATION TYPICALLY ENCOUNTERED ON EARTH, SUCH AS X- AND GAMMA-RAYS. IT IS NOT POSSIBLE TO DETERMINE THE CARCINOGENIC POTENTIAL OF SUCH RADIATIONS DIRECTLY IN ASTRONAUTS, SO IT BECOMES NECESSARY TO RELY ON SURROGATE EXPERIMENTAL SYSTEMS TO PROVIDE THIS INFORMATION. BECAUSE THEY CAUSE CANCER, BECAUSE THEY FOUND IN VIRTUALLY ALL CANCERS, AND BECAUSE THEY RESPOND TO DOSE IN BIOPHYSICALLY PREDICTABLE WAYS, THE FORMATION NONLETHAL (TRANSMISSIBLE) CHROMOSOME ABERRATIONS REPRESENTS AN EXCELLENT SURROGATE MODEL TO STUDY RADIATION CARCINOGENESIS. AND YET, ONLY RECENTLY HAVE WE BEGUN TO REALLY UNDERSTAND THE MOLECULAR PROCESSES GOVERNING ABERRATION FORMATION, INCLUDING DIFFERENCES THAT PROBABLY EXIST IN THE WAY THAT THEY ARE PRODUCED BY SPARSELY- VERSUS DENSELY-IONIZING RADIATIONS. WE PROPOSE USING WHOLE GENOME SEQUENCING TO CHARACTERIZE STRUCTURAL CHANGES TO THE DNA OF NORMAL HUMAN CELLS THAT ACCOMPANY THE FORMATION OF TRANSMISSIBLE CHROMOSOME ABERRATIONS. WE FOCUS OUR STUDY ON PORTIONS OF THE GCR SPECTRA THAT ARE LIKELY TO BE ENCOUNTERED IN DEEP SPACE, AND WHICH WE HYPOTHESIZE WILL ELICIT DIFFERENT BIOLOGICAL RESPONSES AT THE DNA LEVEL.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX15AG74G  
Wednesday, January 6, 2016
$138,600.00
7500: Department of Health and Human Services
00272: NIH, NIAID DEA OA OFC ACQUISITIONS

C: DELIVERY ORDER
IGF::OT::IGF OTHER FUNCTIONS - THE PURPOSE OF THIS MODIFICATION IS TO: (1) EXERCISE OPTION 2A IN THE AMOUNT OF $138,600; (2) UPDATE ARTICLE F.1; AND (3) UPDATE THE TASK ORDER CLAUSES.
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200009     HHSN272201000040I  
Monday, December 21, 2015
$26,343.15
8000: National Aeronautics and Space Administration
NSSC0: NASA SHARED SERVICES CENTER

F: COOPERATIVE AGREEMENT
THE TRAINING REQUIREMENTS FOR SPACE MEDICINE OPERATIONAL AND RESEARCH PROVIDERS ARE UNIQUE. AS PARTNERS IN THIS SPACE MEDICINE FOCUSED RESIDENCY PROGRAM, NASA AND THE UNIVERSITY OF TEXAS MEDICAL BRANCH (UTMB) HAVE A 21-YEAR TRACK RECORD OF SUCCESSFULLY SELECTING AND TRAINING OUTSTANDING PHYSICIANS WHO PROGRESS TO ACTIVELY SUPPORT NASA AND MEET NEEDS OF THE U.S. SPACE PROGRAM. NOT ONLY ARE THE RESIDENTS TRAINED FOR SPACE MEDICINE SUPPORT AT NASA, THEY ALSO COMPLETE THE CORE COMPETENCIES SET BY THE ACCREDITATION COUNCIL ON GRADUATE MEDICAL EDUCATION (ACGME), LEADING TO CERTIFICATION IN AEROSPACE MEDICINE BY THE AMERICAN BOARD OF PREVENTIVE MEDICINE. UTMB OFFERS GRADUATE COURSES AS PART OF THE APPROVED MASTER OF PUBLIC HEALTH (MPH) WITH AN AEROSPACE MEDICINE TRACK AND PRACTICUM ACTIVITIES. OTHER EDUCATIONAL ACTIVITIES, SUCH AS JOURNAL CLUB AND AEROSPACE GRAND ROUNDS ARE ESSENTIAL TO SPACE MEDICINE PRACTITIONERS, AND ARE AVAILABLE LOCALLY AND REMOTELY FOR PHYSICIANS AT ALL THE NASA CENTERS, SATELLITE LOCATIONS, AND STREAMED LIVE. THIS ALLOWS PRACTICING PHYSICIANS TO TAKE ADVANTAGE OF OPPORTUNITIES TO IMPROVE THEIR CLINICAL AND ACADEMIC SKILLS AND MEET THE CONTINUING MEDICAL EDUCATION (CME) REQUIREMENTS OF STATE LICENSING BOARDS. UTMB ALSO COORDINATES OTHER ACTIVITIES FOR NASA PHYSICIANS AND RESIDENTS, SUCH AS VOLUNTEER SERVICE PROJECTS, PROVIDING MEDICAL SUPPORT FOR THE WINGS OVER HOUSTON AIRSHOW AND THE HOUSTON MARATHON, CME TRAINING SUCH AS ADVANCED CARDIAC LIFE SUPPORT, BASIC LIFE SUPPORT, AND PRE-HOSPITAL TRAUMA LIFE SUPPORT TRAINING, AS WELL AS OPPORTUNITIES FOR ADJUNCT FACULTY APPOINTMENTS, MEDICAL CREDENTIALING, AND TEACHING. NO OTHER ACADEMIC INSTITUTION PROVIDES ACADEMIC AND PRACTICUM ACTIVITIES SO CLOSELY TIED TO MEDICAL OPERATIONS AND SCIENCE SUPPORT IN THE SPACE PROGRAM. UTMB ALSO MAINTAINS AFFILIATION AGREEMENTS WITH MILITARY AND FEDERAL AVIATION-RELATED INSTITUTIONS SUCH AS THE USAF SCHOOL OF AEROSPACE MEDICINE, WRIGHT-PATTERSON AIR FORCE BASE, THE US ARMY SCHOOL OF AVIATION MEDICINE, AND THE FAA CIVIL AEROSPACE MEDICAL INSTITUTE THAT BENEFIT NOT ONLY NASA BUT THE MILITARY AND CIVILIAN CREWMEMBERS THESE PHYSICIANS EVENTUALLY SUPPORT. RESIDENT PHYSICIANS SUPPORTED BY THIS AGREEMENT ARE TRAINED IN ALL ASPECTS OF AEROSPACE MEDICINE, AND UPON GRADUATION ARE ABLE TO FUNCTION IN ENVIRONMENTS AS DIVERSE AS GENERAL AVIATION, COMMERCIAL AVIATION, SPACE FLIGHT, AND IN GOVERNMENTAL AND ACADEMIC INSTITUTIONS. IN PREPARATION FOR FUTURE INCREASED COOPERATION WITH THE COMMERCIAL SPACEFLIGHT INDUSTRY, RESIDENTS ARE GIVEN EXPERIENCE IN THIS ARENA AS WELL. GRADUATES OF THE AEROSPACE MEDICINE RESIDENCY PROGRAM ARE IN DEMAND, AND IT IS PREDICTED THAT THIS DEMAND WILL CONTINUE THROUGH THE LIFE CYCLE OF THE ISS AND ON TO FUTURE EXPLORATION MISSIONS. TO DATE, 30 OF THE 40 PROGRAM'S GRADUATES HAVE BEEN EMPLOYED BY NASA OR ONE OF ITS PRIMARY CONTRACTORS. THE TRAINING PARTNERSHIP PRODUCES GRADUATES THAT ARE IMMEDIATELY PRODUCTIVE WHEN HIRED. NASA AND UTMB HAVE A UNIQUE OPPORTUNITY TO CONTINUE THIS PRODUCTIVE PARTNERSHIP IN TRAINING THE NEXT GENERATION OF SPACE MEDICINE PHYSICIANS TO LEAD THE FIELD IN RESEARCH AND OPERATIONAL SUPPORT. UTMB PROPOSES TO CONTINUE PRODUCING GRADUATES TRAINED AND BOARD ELIGIBLE IN AEROSPACE MEDICINE, WITH AN EMPHASIS IN SPACE. UTMB IS REQUESTING NASA'S CONTINUED FINANCIAL SUPPORT FOR GRADUATE MEDICAL EDUCATION TRAINING IN AEROSPACE MEDICINE. IN ORDER TO FACILITATE LONG TERM PLANNING, UTMB IS SEEKING A NEW FIVE YEAR COOPERATIVE AGREEMENT.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX16AC91A  
Tuesday, November 24, 2015
$105,000.00
8000: National Aeronautics and Space Administration
NSSC0: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
HIGHLY ENERGETIC HEAVY IONS (HZE), OF THE TYPE FOUND IN GALACTIC COSMIC RAYS, DEPOSIT ENERGY IN CLOSELY SPACED AREAS ALONG THE PATHS (TRACKS) THESE IONS TAKE AS THEY PASS THROUGH CELLS. THIS TIGHT SPACING MAKES THESE PARTICLES PARTICULARLY DAMAGING TO IMPORTANT CELLULAR COMPONENTS SUCH AS CHROMOSOMES. SOME OF THE ENERGY OF THE HZE PARTICLE CAN BE TRANSFERRED TO ELECTRONS (DELTA RAYS) WHICH CAN TRAVEL RELATIVELY LONG DISTANCES AND PRODUCE DAMAGE IN CELLS FAR REMOVED FROM THE ORIGINAL PARTICLE TRACK. THE CELL HAS MECHANISMS THAT CAN REJOIN BROKEN CHROMOSOMES BUT THESE PROCESSES CAN MAKE MISTAKES CAUSING SEGMENTS OF THE CHROMOSOMES INVOLVED TO EXCHANGE. IT IS OUR HYPOTHESIS THAT DAMAGE PRODUCED BY DELTA RAYS FROM HZE PARTICLE TRACKS CAN INTERACT WITH DAMAGE NEAR THE CENTER OF AN INDEPENDENT PARTICLE TRACK AND ADD MORE BREAKS TO AN EXCHANGE THAT MIGHT BE FORMING CLOSE TO THE CENTER OF THE SECOND TRACK. SUCH INTERACTIONS WILL ADD CURVATURE TO THE CHROMOSOME EXCHANGE BREAKPOINT DOSE RESPONSE. WE PLAN TO TEST THIS HYPOTHESIS BY IRRADIATING HUMAN FIBROBLASTS AND LYMPHOCYTES WITH PARTICLES OF DIFFERENT ENERGY CHOSEN IN SUCH A WAY THAT THEY DEPOSIT THE SAME AMOUNT OF ENERGY ALONG A SPECIFIC LENGTH OF THEIR TRACK AND MEASURE THE RESULTING CHROMOSOME EXCHANGES. THE ENERGY IMPARTED TO THE DELTA RAYS WILL BE PROPORTIONAL TO THE ENERGY OF THE HZE PARTICLE SO THAT THE DELTA RAYS FROM A HIGHER ENERGY PARTICLE CAN POTENTIALLY TRAVEL LONGER DISTANCES. THIS SUGGESTS TO US THAT THEY MAY BE ABLE TO ADD MORE BREAKS TO EXCHANGES AND INCREASE THE CURVATURE OF THE DOSE RESPONSE. CHROMOSOME ABERRATIONS ARE IMPORTANT CHANGES IN CELLS THOUGHT TO BE CAUSATIVE OR DIAGNOSTIC OF RADIATION CARCINOGENESIS. A BETTER UNDERSTANDING OF THE MECHANISMS OF THEIR FORMATION WILL REDUCE UNCERTAINTIES IN MODELS USED BY NASA TO DESIGN SPACECRAFT BETTER ABLE TO PROTECT ASTRONAUTS FROM RADIATION.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX14AC76G  
Monday, November 23, 2015
($108.93)
9700: Department of Defense
N0622A: NAVY MEDICINE PROFESSIONAL

C: DELIVERY ORDER
IGF::OT::IGF TUITION AND FEES
U005: EDUCATION/TRAINING- TUITION/REGISTRATION/MEMBERSHIP FEES

  8E43     N0014098G2541  
Thursday, November 19, 2015
$0.00
7500: Department of Health and Human Services
00272: NIH, NIAID DEA OA OFC ACQUISITIONS

C: DELIVERY ORDER
OTHER FUNCTION: THE PURPOSE OF THIS MODIFICATION IS TO: (1) EXTEND THE COMPLETION DATES FOR THE BASE AND OPTION 1 PERIODS AT NO ADDITIONAL COST TO THE GOVERNMENT; AND (2) UPDATE THE CONTRACT CLAUSES.
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200003     HHSN272201000040I  
Wednesday, November 18, 2015
$0.00
7500: Department of Health and Human Services
00272: NIH, NIAID DEA OA OFC ACQUISITIONS

C: DELIVERY ORDER
OTHER FUNCTION: THE PURPOSE OF THIS MODIFICATION IS TO CHANGE THE PRINCIPAL INVESTIGATOR TO DR. DAVID BEASLEY UNDER THE KEY PERSONNEL IN ARTICLE G.2.
AN11: R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

  HHSN27200003     HHSN272201000040I