CAGE 1CNP4 - UNIVERSITY OF TEXAS SOUTHWESTERN
USA

UNIVERSITY OF TEXAS SOUTHWESTERN

MEDICAL CENTER

DBA SOUTHWESTERN MEDICAL SCHOOL

CAGE Code: 1CNP4
DUNS: 800771545
5323 HARRY HINES BLVD
DALLAS TX 75390-7208
UNITED STATES

Telephone: 214-648-4494
Fax: 214-648-4474

UNIVERSITY OF TEXAS SOUTHWESTERN, MEDICAL CENTER, DBA SOUTHWESTERN MEDICAL SCHOOL is an Active Commercial Supplier with the Cage Code 1CNP4 and is tracked by Dun & Bradstreet under DUNS Number 800771545.

Additional Data For CAGE 1CNP4

SIC Code 1:8221
Status:A
Type:F
Size:E
Primary Business:N
Type of Business:N
Woman Owned:N
CAO:N68892
ADP CNT CT:N66018

USA Government Contracting Activity for 1CNP4

Monday, December 11, 2017
$3,590.00
3600: Department of Veterans Affairs
36C671: 671-SAN ANTONIO (00671)

B: PURCHASE ORDER
PURCHASE DSAEK CORNEA
6505: DRUGS AND BIOLOGICALS

  36C25718P0355  
Monday, December 11, 2017
$0.00
7500: Department of Health and Human Services
75N920: NATIONAL INSTITUTES OF HEALTH NHLBI

D: DEFINITIVE CONTRACT
BABY HUG FOLLOW-UP STUDY II
AN12: R&D- MEDICAL: BIOMEDICAL (APPLIED RESEARCH/EXPLORATORY DEVELOPMENT)

  HHSN268201200019C     NHLBIHB1202  
Tuesday, November 21, 2017
($4.51)
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
MOUSE GLIOMA MODELS TO ESTIMATE CANCER RISKS FROM HZE PARTICLE EXPOSURE THERE IS A PAUCITY OF SYSTEMATIC STUDIES CARRIED OUT WITH WELL-DEFINED MODEL SYSTEMS TO EVALUATE CANCER RISKS TO ASTRONAUTS FROM EXPOSURE TO CHARGED PARTICLES. GLIOBLASTOMAS (GBM) ARE DEADLY BRAIN TUMORS WITH VERY POOR PROGNOSIS AND ARE THE THIRD LEADING CAUSE OF CANCER-RELATED DEATHS AMONG ADULTS AGED 30-50 YEARS. EXPOSURE TO IONIZING RADIATION IS THE ONLY KNOWN RISK FACTOR FOR THE DEVELOPMENT OF THESE TUMORS. UNPRECEDENTED ADVANCES HAVE RECENTLY BEEN MADE IN THE GENETIC ANALYSIS OF THESE TUMORS AS PART OF THE HUMAN CANCER GENOME ATLAS PROJECT. FIVE KEY GENETIC CHANGES PREDOMINATE IN GBMS - LOSS OF INK4A, ARF, P53 AND/OR PTEN, AND AMPLIFICATION OF EGFR. UNDER THE AUSPICES OF OUR CURRENTLY-FUNDED NASA GRANT, OUR LAB HAS VALIDATED SENSITIVE MOUSE MODELS WITH BRAIN-TARGETED DELETIONS OF THESE GENES REPRESENTING PROGRESSIVE STEPS IN GLIOMAGENESIS. BY USING GENETICALLY "PRE-SENSITIZED" MODELS, WE ARE CAPABLE OF RAPIDLY ASSESSING BRAIN TUMOR DEVELOPMENT AFTER EXPOSURE TO PARTICLE RADIATION. OUR CURRENT RESEARCH SHOWS THAT FE IONS ARE 4-FOLD MORE GLIOMAGENIC THAN X-RAYS. ADDITIONALLY, WE HAVE DEMONSTRATED THAT FE-INDUCED GLIOMAGENESIS IS TRIGGERED BY SPECIFIC ONCOGENIC EVENTS, SUCH AS MET AMPLIFICATION, THAT ARE ALSO RELEVANT TO HUMAN GBMS. IN THIS (RENEWAL) PROPOSAL, WE AIM TO USE FURTHER FINESSED VERSIONS OF OUR CURRENT MOUSE MODELS TO ANALYZE NOT ONLY THE TUMORIGENIC POTENTIAL OF AN ARRAY OF PARTICLES AND DOSES, BUT ALSO TO IDENTIFY THE CELL TYPES IN THE BRAIN THAT ARE MOST SUSCEPTIBLE TO TRANSFORMATION FOLLOWING CHARGED PARTICLE EXPOSURE. FURTHERMORE, WE PROPOSE TO UNDERTAKE LARGE SCALE ONCOGENOMIC STUDIES TO IDENTIFY PATHWAYS THAT ARE ALTERED IN PARTICLE-INDUCED GBMS. THE RESULTS OF THIS STUDY WILL GREATLY FACILITATE THE ESTIMATION OF CANCER RISKS FROM CHARGED PARTICLE EXPOSURE AND SHOULD ULTIMATELY LEAD TO RADIOPROTECTIVE OR THERAPEUTIC STRATEGIES TO INHIBIT OR TREAT THESE RECALCITRANT TUMORS.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX13AI13G  
Tuesday, November 14, 2017
($102.25)
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
THE UT SOUTHWESTERN MEDICAL CENTER PROPOSAL FOCUSES ON THE DETERMINATION AND QUANTITATION OF RISK FACTORS FROM KEY GENETIC, EPIGENETIC AND CELLULAR FUNCTIONAL CHANGES IN THE MULTI-STEP PATHOGENESIS OF LUNG CANCER FOLLOWING SPACE RADIATION EXPOSURE IN BOTH HUMAN LUNG EPITHELIAL CELLS IN 2D AND 3D (ORGANOTYPIC) CULTURE AND TRANSGENIC MOUSE MODELS OF LUNG CANCER. THESE ASSESSMENTS ARE DESIGNED TO MEASURE EVENTS OF BOTH RADIATION-INDUCED CANCER PROMOTION (OF ALREADY-INITIATED CELLS) AS WELL AS RADIATION-INDUCED INITIATION (MUTATIONAL AND EPIGENETIC) EVENTS, AND INCLUDE EFFECTS ON STEM CELLS. 3D CULTURE AND ANIMAL MODELS WILL MEASURE RISK FACTORS IN BOTH TISSUE SURROGATES AND IN VIVO LUNG TISSUES. THESE INDIVIDUAL RISK FACTORS CAN THEN BE USED TO DEVELOP HYPOTHESES THAT WILL PERMIT MODELING FOR OVERALL RISK OF DEVELOPING INCREASES IN FATAL LUNG CANCER FROM EXPOSURE TO IRRADIATION THAT ARE LIKELY TO BE EXPERIENCED BY ASTRONAUTS ON DEEP-SPACE MISSIONS. WE SPECIFICALLY ADDRESS RADIATION CARCINOGENESIS GAP 1 (EXPERIMENTAL MODELS OF TUMOR DEVELOPMENT TO BE EXTRAPOLATED TO HUMAN RISK PROJECTIONS); AND GAPS 3-6 (MODELS OF CANCER RISK TO REDUCE UNCERTAINTIES IN RADIATION QUALITY EFFECTS, DOSE-RATE DEPENDENCIES, INDIVIDUAL RADIATION SENSITIVITY INCLUDING GENETIC AND EPIGENETIC FACTORS, AGE AND GENDER). THE NEW DATA FROM THIS RESEARCH WILL BE APPLIED IN ADDRESSING HOW SYSTEM BIOLOGY APPROACHES (GAP 7) CAN BE USED TO INTEGRATE THE RESULTS SO THAT MODELING WILL IMPROVE THE PREDICTION OF THE RISK OF FATAL CANCERS FROM EXPOSURE TO SPACE RADIATION. THIS PROPOSAL HAS 4 PROJECTS: 1. HZE PARTICLE EXPOSURE AND THE RISK FOR HUMAN LUNG CARCINOGENESIS; 2. MOUSE MODELS OF LUNG CANCER AFTER HZE PARTICLE IRRADIATION; 3. ORGANOTYPIC (3D) HUMAN AND MOUSE IN VIVO MODELS OF GENOMIC INSTABILITY FOR HZE PARTICLE INDUCED LUNG CARCINOGENESIS; AND 4. INTEGRATING BIOMARKERS OF LUNG CANCER PATHOGENESIS FOR RISK ASSESSMENT AFTER HZE PARTICLE IRRADIATION. PROJECTS ARE SUPPORTED BY ADMINISTRATIVE AND BIOINFORMATICS, BIOSTATISTICS AND DATABASE CORES.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX11AC54G  
Tuesday, November 7, 2017
$24,200.00
1500: Department of Justice
15JA77: U.S. ATTORNEYS OFFICE-TX(N) (USA77)

B: PURCHASE ORDER
EXPERT WITNESS SERVICES FOR UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER - SHIVANI DESAI, MD
R424: SUPPORT- PROFESSIONAL: EXPERT WITNESS

  15JA7718P00000020  
Friday, November 3, 2017
($128,711.29)
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

B: PURCHASE ORDER
IGF::OT::IGF
Q301: MEDICAL- LABORATORY TESTING

  VA25713P0427  
Sunday, October 1, 2017
$424,999.98
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

B: PURCHASE ORDER
IGF::OT::IGF REFERENCE LAB SERVICES
Q301: MEDICAL- LABORATORY TESTING

  VA25717P1727  
Wednesday, September 20, 2017
($100,000.02)
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

B: PURCHASE ORDER
IGF::OT::IGF REFERENCE LAB SERVICES
Q301: MEDICAL- LABORATORY TESTING

  VA25717P1727  
Wednesday, September 20, 2017
$15,000.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
THE INTEGRATED CARDIOVASCULAR (ICV) EXPERIMENT WAS PERHAPS THE MOST AMBITIOUS AND COMPREHENSIVE CARDIOVASCULAR STUDY PERFORMED IN THE ISS ERA. ALTHOUGH MANY QUESTIONS REGARDING THE CARDIOVASCULAR ADAPTATION TO LONG DURATION SPACEFLIGHT WERE ANSWERED, A NUMBER OF OTHER KEY QUESTIONS WERE RAISED THAT WE PROPOSE TO ADDRESS IN THIS OMNIBUS APPLICATION. THE FOCUS OF THIS APPLICATION IS WITH THE RISK OF ATRIAL FIBRILLATION (AFIB), THE MOST COMMON CLINICAL ARRHYTHMIA IN THE ASTRONAUT DEMOGRAPHIC. WITH THE AGING OF THE ASTRONAUT POPULATION, NUMEROUS CASES OF AFIB HAVE BEEN OBSERVED, PRIMARILY IN ACTIVE ASTRONAUTS ON THE GROUND. THEREFORE AFIB HAS BECOME AN ISSUE OF INCREASING IMPORTANCE FOR FLIGHT MEDICINE. IN ADDITION, IT MAY BE THAT THE EXTENSIVE EXERCISE PERFORMED ON THE ISS, WHICH PREVENTS CARDIAC ATROPHY AND CV DECONDITIONING, MIGHT ACTUALLY INCREASE THE RISK OF ATRIAL FIBRILLATION AS IT DOES IN COMPETITIVE ATHLETES. BECAUSE OF THE EXTENSIVE CARDIAC STRUCTURAL AND ARRHYTHMIA ANALYSIS ALREADY PERFORMED BY THE ICV INVESTIGATORS, ONLY MINOR MODIFICATIONS TO THE ICV ANALYSIS PLAN WOULD ALLOW HIGH RESOLUTION ASSESSMENT OF AFIB RISK. WE PROPOSE TO ANALYZE OUR ALREADY ACQUIRED DATA TO ASSESS ATRIAL MORPHOLOGY, ELECTROPHYSIOLOGY AND RISK FOR AFIB IN COMPLETED ICV SUBJECTS.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX15AP25G  
Monday, September 18, 2017
$0.00
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

B: PURCHASE ORDER
IGF::OT::IGF REFERENCE LAB SERVICES
Q301: MEDICAL- LABORATORY TESTING

  VA25717P1727  
Monday, September 18, 2017
$0.00
9700: Department of Defense
W81K00: W40M USA HLTH CONTRACTING ACT

B: PURCHASE ORDER
CADAVERS
6910: TRAINING AIDS

  W81K0017P0556  
Monday, September 18, 2017
$0.00
9700: Department of Defense
W81K00: W40M USA HLTH CONTRACTING ACT

B: PURCHASE ORDER
CADAVER, WHOLE, FRESH
6910: TRAINING AIDS

  W81K0017P0700  
Friday, September 15, 2017
$2,983.51
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

C: DELIVERY ORDER
IGF::OT::IGF VET TECH SERVICES
R416: SUPPORT- PROFESSIONAL: VETERINARY/ANIMAL CARE

  VA25717J2817     VA25715D0191  
Friday, September 15, 2017
$230,000.00
7500: Department of Health and Human Services
75F401: FDA OFFICE OF ACQ GRANT SVCS

B: PURCHASE ORDER
IGF::OT::IGF SEQUENCE GENOMIC DNA
B504: SPECIAL STUDIES/ANALYSIS- CHEMICAL/BIOLOGICAL

  HHSF223201710579A     FDA_172331176204  
Thursday, September 14, 2017
($482,892.68)
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

B: PURCHASE ORDER
IGF::OT::IGF LAB TESTING
Q301: MEDICAL- LABORATORY TESTING

  VA25716P1662  
Tuesday, September 5, 2017
$14,806.00
7500: Department of Health and Human Services
75N980: NATIONAL INSTITUTES OF HEALTH OLAO

B: PURCHASE ORDER
IGF::OT::IGF GENETIC FACTORS IN TASTE PERCEPTION AND TOBACCO USAGE. PRIOR AWARD: HHSN263201300011C
Q301: MEDICAL- LABORATORY TESTING

  HHSN263201700530P  
Friday, September 1, 2017
$499,874.02
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

D: DEFINITIVE CONTRACT
IGF::OT::IGF OPHTHALMOLOGY - AFFILIATE (SHORT TERM)
Q511: MEDICAL- OPHTHALMOLOGY

  VA25717C0159     VA257-17-Q-1313  
Thursday, August 17, 2017
$4,800.00
7500: Department of Health and Human Services
75N930: NATIONAL INSTITUTES OF HEALTH NIAID

B: PURCHASE ORDER
IGF::OT::IGF AUTO-ANTIBODY MICROARRAY PROFILING SERVICE
Q301: MEDICAL- LABORATORY TESTING

  HHSN272201701011P  
Thursday, August 3, 2017
$499,252.87
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

D: DEFINITIVE CONTRACT
IGF::OT::IGF NEUROSURGERY
Q510: MEDICAL- NEUROLOGY

  VA25717C0143     VA257-17-Q-1126  
Thursday, August 3, 2017
$499,355.27
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

D: DEFINITIVE CONTRACT
IGF::OT::IGF GENERAL/ONCOLOGY/VASCULAR SURGERY
Q523: MEDICAL- SURGERY

  VA25717C0142     VA257-17-Q-1125  
Tuesday, August 1, 2017
$33,023.00
9700: Department of Defense
N0622A: NAVY MEDICINE PROFESSIONAL

C: DELIVERY ORDER
IGF::OT::IGF TUITION AND FEES
U005: EDUCATION/TRAINING- TUITION/REGISTRATION/MEMBERSHIP FEES

  N0622A17F00NM     N0014098G2532  
Tuesday, August 1, 2017
$229,841.36
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

D: DEFINITIVE CONTRACT
IGF::OT::IGF ANESTHESIOLOGY (CRITICAL CARE INTENSEVIST)
Q501: MEDICAL- ANESTHESIOLOGY

  VA25717C0146     VA257-17-Q-1154  
Friday, July 28, 2017
$156,698.00
7500: Department of Health and Human Services
75N920: NATIONAL INSTITUTES OF HEALTH NHLBI

D: DEFINITIVE CONTRACT
BABY HUG FOLLOW-UP STUDY II
AN12: R&D- MEDICAL: BIOMEDICAL (APPLIED RESEARCH/EXPLORATORY DEVELOPMENT)

  HHSN268201200019C     NHLBIHB1202  
Tuesday, July 25, 2017
$0.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
AN UNAVOIDABLE CONSEQUENCE OF DEEP SPACE MISSIONS IS EXPOSURE TO GALACTIC COSMIC RADIATION (GCR), WHICH INCLUDES HIGH (H) ATOMIC NUMBER (Z) AND ENERGY (E) PARTICLES PARTICLES LIKE FE, SI, AND O. ESTIMATING RADIATION RISKS TO THE BRAIN BY HZE PARTICLES ENCOUNTERED DURING SPACE MISSIONS IS A HIGH RESEARCH PRIORITY. RODENTS EXPOSED TO HZE PARTICLES HAVE COGNITIVE AND PERFORMANCE DEFICITS IN NUMEROUS BEHAVIORAL TASKS, INCLUDING THOSE THAT RELY ON THE HIPPOCAMPUS, A BRAIN REGION INVOLVED IN LEARNING AND MEMORY. NOTABLY, WE HAVE FOUND THAT MATURE MICE (OF EQUIVALENT AGE TO ASTRONAUTS) EXPOSED TO EITHER SI OR FE HZE PARTICLE IRRADIATION (IRR) ACTUALLY SHOW IMPROVED PERFORMANCE ON A DIFFICULT HIPPOCAMPAL TASK (DISCRIMINATION OF 2 SIMILAR CONTEXTS) WITHOUT INFLUENCING PERFORMANCE ON AN EASIER HIPPOCAMPAL TASK OR OTHER BEHAVIORS. HERE WE PROPOSE THREE AIMS TO UNDERSTAND THIS IMPROVED CONTEXTUAL PATTERN SEPARATION AFTER HZE PARTICLE IRR. IN AIM 1, WE HYPOTHESIZE THAT HZE PARTICLE IRR-INDUCED IMPROVED PATTERN SEPARATION IS LINKED TO IMPROVED PERFORMANCE IN OTHER COGNITIVE TESTS. IN AIM 2, WE HYPOTHESIZE THAT HZE PARTICLE IRR-INDUCED IMPROVED PATTERN SEPARATION IS LINKED IN THE SHORT-TERM TO DIMINISHED STRESS-INDUCED EMERGENCE OF SOCIAL AVOIDANCE BEHAVIORS. IN AIM 3, WE HYPOTHESIZE THAT HZE PARTICLE IRR-INDUCED IMPROVED PATTERN SEPARATION IS ASSOCIATED WITH INDICES OF ENHANCED HIPPOCAMPAL ACTIVITY. TAKEN TOGETHER, THESE AIMS WILL ADDRESS WHETHER THE HZE PARTICLE IRR-INDUCED IMPROVEMENT IN PATTERN SEPARATION IS BENEFICIAL OR DETRIMENTAL TO MISSION SUCCESS (AIMS 1, 2), WILL REFLECT THE FUNCTIONAL (AIMS 1, 2) AND CELLULAR/MOLECULAR (AIM 3) INTEGRITY OF NEURAL CIRCUITRY CONTRIBUTING TO MISSION-RELEVANT BEHAVIORS, AND WILL ADVANCE NASAS KNOWLEDGE OF THE SHORT- AND LONG-TERM HEALTH OF NEURAL NETWORKS NEEDED TO COMPLETE DEEP SPACE MISSIONS.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX15AE09G  
Friday, July 21, 2017
$100,000.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
OVERALL HYPOTHESIS.. LOW DOSE RADIATION INDUCES MOLECULAR MANIFESTATIONS OF A PRO INFLAMMATORY RESPONSE AS A FUNCTION OF RADIATION TYPE, RADIATION DOSES, DOSES RATES, LET VALUE, AND TIME. AN ORAL AVAILABLE ANTI INFLAMMATORY COUNTERMEASURE, ALREADY IN HUMAN CLINICAL TRIALS WITH A GOOD SAFETY PROFILE, WILL SIGNIFICANTLY REDUCE PROTON AND HZE ION EXPOSURE ASSOCIATED TUMOR INITIATION AND PROGRESSION. ALTHOUGH BIOLOGICAL MECHANISMS OF NORMAL TISSUE RADIATION INJURY ARE NOT COMPLETELY UNDERSTOOD, THE ROLES OF SPECIFIC PATHWAYS IN SOME CELL TYPES ARE BECOMING ELUCIDATED. WHILE CELL DEATH IS GENERALLY BELIEVED TO BE ONE THE MAIN CAUSES OF TISSUE INJURY FROM EXPOSURE TO HIGHER DOSES OF LOW AND HIGH LET RADIATION, THE DOSE AND DOSE RATES LIKELY TO BE ENCOUNTERED BY AN ASTRONAUT ON LONG TERM MISSIONS INTO DEEP SPACE ARE UNLIKELY TO CAUSE MASSIVE CELL DEATH. PATHOLOGICAL MANIFESTATIONS AFTER LOW DOSE SPACE RADIATION SHOULD BE STRONGLY INFLUENCED BY NON CYTOTOXIC RADIATION EFFECTS, RESULTING IN INCREMENTAL SMALL CHANGES IN CELL FUNCTION, IMMUNE (MICRO ENVIRONMENTAL)ALTERED RESPONSES, AND CHANGES IN METABOLISM. TO MORE FULLY UNDERSTAND THE TISSUE EFFECTS OF EXPOSURE TO SPACE RADIATION COMPARED TO BACKGROUND CANCER ON EARTH, IT WILL REQUIRE A MORE INTEGRATED OMICS AND BIOLOGICAL END POINT ANALYSIS AS IS PROPOSED IN THIS FOCUSED PROPOSAL USING AGE APPROPRIATE MOUSE MODELS TO HELP FORM THE BASIS OF A NEW DESCRIPTION OF RADIATION QUALITY EFFECTS AND CANCER RISK. OUR PUBLISHED DATA (CLIN CANCER RESEARCH, 2014) LED US TO THE HYPOTHESIS THAT PROTRACTED FRACTIONATED HIGH LET IRRADIATION CAN HAVE LONG TERM EFFECTS BY CHANGING THE MICROENVIRONMENT IN TISSUES LEADING TO A PRO INFLAMMATORY CANCER PROGRESSING PHENOTYPE. IMPORTANTLY, THE MICROARRAY SIGNATURES IN THESE PUBLISHED STUDIES ON THE K RAS LUNG CANCER SUSCEPTIBLE MOUSE MODEL OF LUNG CANCER WERE SHOWN TO BE APPLICABLE TO OVERALL SURVIVAL IN HUMANS WITH LUNG AND BREAST CANCER. THUS, THE STUDIES PROPOSED ARE LIKELY TO BE APPLICABLE TO HUMAN RISKS. IN THE CURRENT PROPOSAL WE WILL TEST THIS HYPOTHESIS RIGOROUSLY WITH NORMAL MICE, INDUCIBLE EGFR MUTANT MICE SUSCEPTIBLE TO LUNG CANCER AND A COLON CANCER SUSCEPTIBLE MOUSE MODEL (CPC APC) BY INCORPORATING THE COUNTERMEASURE ARM IN ALREADY APPROVED STUDIES. WE HAVE ALREADY ESTABLISHED DOSE RESPONSES FOR TUMOR INCIDENCE IN THE K RAS AND CPC APC MOUSE MODELS USING SI, O, PROTONS AND SPE SIMULATIONS AND PROPOSE TO DEMONSTRATE THAT ORAL DELIVERABLE CDDO (WITH A KNOWN MECHANISM OF ACTION) USING MISSION RELEVANT IRRADIATION DOSES CAN SIGNIFICANTLY DECREASE TUMOR INCIDENCE (EGFR MUTANT MICE WITHOUT INDUCTION OF MUTANT EGFR ARE ESSENTIALLY WT MICE) OR PROGRESSION INVASIVENESS (DOXYCYCLINE INDUCTION OF MUTANT EGFR EITHER BEFORE OR AFTER IRRADIATION). WE WILL FOCUS ON INTERMEDIATE PERSISTENT EFFECTS (14 TO 100 DAYS POST IR) INCLUDING SOME LONG TERM EFFECTS (150 TO 200 DAYS). WE WILL CONDUCT TISSUE MICRO DISSECTIONS AND OMICS ANALYSES OF NORMAL TISSUES, PRECANCEROUS LESIONS, MALIGNANT LESIONS, AND CLEARED MARGINS SURROUNDING THE PRECANCEROUS LESIONS IN MICE WITH AND WITHOUT BEING PROVIDED THE MEDICAL RADIOPROTECTOR, CDDO. WE PROPOSE THAT USING A VARIETY OF RADIATION QUALITIES AND BIOLOGICAL MODELS, WE WILL BE ABLE TO DISSECT THE IMPORTANT DIFFERENCE BETWEEN SPACE RADIATION AND TERRESTRIAL RADIATION. THIS WILL LEAD TO IMPROVED RISK QUANTIFICATION AND DEVELOPMENT OF NEW SYSTEMS BIOLOGY RISK MODELING APPROACHES THAT CAN BE EXTRAPOLATED TO HUMAN CANCER RISKS.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX16AE08G  
Monday, July 17, 2017
$0.00
9700: Department of Defense
W81K00: W40M USA HLTH CONTRACTING ACT

B: PURCHASE ORDER
WHOLE FRESH CADAVERS
6509: DRUGS AND BIOLOGICALS, VETERINARY USE

  W81K0017P0491  
Thursday, July 13, 2017
$1,748.02
9700: Department of Defense
N0622A: NAVY MEDICINE PROFESSIONAL

C: DELIVERY ORDER
IGF::OT::IGF TUITION AND FEES
U005: EDUCATION/TRAINING- TUITION/REGISTRATION/MEMBERSHIP FEES

  8E29     N0014098G2532  
Wednesday, July 12, 2017
$0.00
9700: Department of Defense
W81K00: W40M USA HLTH CONTRACTING ACT

B: PURCHASE ORDER
HEAD EMBALMED (DYE INJECTED)
6510: SURGICAL DRESSING MATERIALS

  W81K0017P0513  
Monday, July 3, 2017
$0.00
7500: Department of Health and Human Services
75F401: FDA OFFICE OF ACQ GRANT SVCS

B: PURCHASE ORDER
IGF::OT::IGF MIRNA SEQUENCING FOR DILI STUDY- INVOICE PROCESSING SUPPORT
B504: SPECIAL STUDIES/ANALYSIS- CHEMICAL/BIOLOGICAL

  HHSF223201410112A  
Saturday, July 1, 2017
$271,889.68
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

D: DEFINITIVE CONTRACT
IGF::OT::IGF ANESTHESIOLOGY (CARDIOTHORACIC)
Q501: MEDICAL- ANESTHESIOLOGY

  VA25717C0121     VA257-17-Q-1135  
Saturday, July 1, 2017
$499,652.76
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

D: DEFINITIVE CONTRACT
IGF::OT::IGF CARDIOTHORACIC SURGEONS&PERFUSIONISTS
Q502: MEDICAL- CARDIO-VASCULAR

  VA25717C0088     VA257-17-Q-0431  
Friday, June 9, 2017
$160,000.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
GALACTIC COSMIC RAYS GCR AND SOLAR PARTICLE EVENTS SPES ARE A MAJOR SOURCE OF CARCINOGENIC RISK FOR ASTRONAUTS ON PROLONGED SPACE MISSIONS. LARGE UNCERTAINTIES EXIST IN THE EXACT ESTIMATION OF CANCER RISKS FROM CHARGED PARTICLES DUE TO THE PAUCITY OF EPIDEMIOLOGICAL DATA IN THIS AREA. FURTHERMORE, A MECHANISTIC UNDERSTANDING OF GENETIC CHANGES UNDERLYING TRANSFORMATION BY PARTICLE RADIATION IS NECESSARY FOR THE DEVELOPMENT OF APPROPRIATE COUNTERMEASURES. THUS, EXPERIMENTAL ANIMAL MODELS THAT CLOSELY MIMIC THE PROCESS OF CARCINOGENESIS IN HUMANS ARE ESSENTIAL FOR ONCOGENIC RISK ASSESSMENT. IN THE COURSE OF OUR CURRENTLY FUNDED 3 YR. NASA PROJECT 2013 2016, WE CHARACTERIZED TWO SENSITIVE AND COMPLEMENTARY MOUSE MODELS THAT CAN BE USED TO ELUCIDATE MOLECULAR MECHANISMS UNDERLYING THE PROCESS OF PARTICLE RADIATION INDUCED GLIOBLASTOMA GBM DEVELOPMENT. GBMS ARE LETHAL BRAIN TUMORS WITH VERY DISMAL PROGNOSIS FOR WHICH RADIATION IS THE ONLY KNOWN RISK FACTOR. GBMS REPRESENT THE THIRD LEADING CAUSE OF CANCERRELATED DEATH AMONG ADULTS AGED 30 50 YEARS THE AVERAGE AGE OF ASTRONAUTS, THE MEAN SURVIVAL AFTER DIAGNOSIS BEING ONLY ABOUT 14 MONTHS. GBM WAS THE FIRST CANCER TO BE ANALYZED BY THE CANCER GENOME ATLAS NETWORK TCGA, AND THE KEY GENETIC ALTERATIONS OCCURRING IN GBM ARE NOW WELL DEFINED. BASED ON THIS INFORMATION, WE UTILIZED TRANSGENIC MICE WITH BRAIN RESTRICTED DELETIONS OF GBM RELEVANT TUMOR SUPPRESSORS IN LOGICAL COMBINATIONS TO ANALYZE THE PROCESS OF CHARGED PARTICLE INDUCED CARCINOGENESIS. WE IDENTIFIED AND CHARACTERIZED TWO COMPLEMENTARY MOUSE GBM MODELS THAT WOULD BE IDEAL FOR STUDYING PARTICLE RADIATION INDUCED CARCINOGENESIS NESTIN CRE INK4AB ARF F F AND NESTIN CRE P53F PTENF. THESE MODELS EXHIBIT A LOW FREQUENCY OF SPONTANEOUS GBMS BUT READILY DEVELOP BRAIN TUMORS AFTER EXPOSURE TO HZE PARTICLES, WHICH RESEMBLE HUMAN HIGH GRADE GLIOMAS IN THEIR GENETIC AND MOLECULAR SIGNATURES. USING THESE MICE, WE HAVE CLEARLY DEMONSTRATED THAT HIGH LINEAR ENERGY TRANSFER LET CHARGED PARTICLES HAVE A GREATER TRANSFORMING POTENTIAL COMPARED TO LOW LET RADIATION, AND HAVE CHARACTERIZED THE MOLECULAR EVENTS UNDERLYING FE IONINDUCED GLIOMAGENESIS IN THESE MODELS THIS WORK SETS THE STAGE FOR QUANTITATIVE STUDIES ON RADIATION QUALITY EFFECTS ON CARCINOGENESIS FOR AN ARRAY OF CHARGED PARTICLES REPRESENTING THE GCR AS PROPOSED IN AIM 1. THESE CHARGED PARTICLES INDUCE COMPLEX DNA DOUBLESTRAND BREAKS DSBS THE ACCURATE REPAIR OF WHICH IS CRITICAL FOR PREVENTING TRANSFORMATION. OUR MODELS WILL ALSO ALLOW US TO DETERMINE WHICH DSB REPAIR PATHWAY REPRESENTS A MAJOR BARRIER TO CHARGED PARTICLE INDUCED GLIOMAGENESIS AS PROPOSED IN AIM 2. THIS INFORMATION WOULD BE FUNDAMENTAL TO THE DEVELOPMENT OF A MECHANISTIC UNDERSTANDING OF CHARGED PARTICLE INDUCED CARCINOGENESIS. WE WILL CROSS THE TRANSGENIC MICE CHARACTERIZED BY US WITH MICE HARBORING BRAIN SPECIFIC ABLATION OF NON HOMOLOGOUS END JOINING NHEJ OR HOMOLOGOUS RECOMBINATION HR REPAIR PATHWAYS NESTIN CRE LIGASE4F F AND NESTIN CRE BRCA2F F THAT WERE ESTABLISHED IN THE LABORATORY OF PROF. PETER MCKINNON COLLABORATOR ON PROJECT. FINALLY, GENOMIC AND BIOINFORMATICS ANALYSES WILL BE USED TO DEFINE GENETIC SIGNATURES UNIQUE TO PARTICLE RADIATION INDUCED GLIOBLASTOMAS AND TO DELINEATE KEY PATHWAYS THAT ARE DE REGULATED DURING HZE INDUCED GLIOMAGENESIS AS PROPOSED IN AIM 3. WE ARE HOPEFUL THAT AN IN DEPTH MECHANISTIC ANALYSIS OF CHARGED PARTICLE INDUCED GLIOMAGENESIS IN THESE VALIDATED MOUSE MODELS WILL HELP US TO MAKE SIGNIFICANT PROGRESS TOWARDS CANCER RISK ASSESSMENTS AND DEVELOPMENT OF PROTECTIVE STRATEGIES FOR CHARGED PARTICLE EXPOSURE.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX16AD78G  
Thursday, June 8, 2017
$39,611.73
9700: Department of Defense
N0622A: NAVY MEDICINE PROFESSIONAL

C: DELIVERY ORDER
IGF::OT::IGF TUITION AND FEES
U005: EDUCATION/TRAINING- TUITION/REGISTRATION/MEMBERSHIP FEES

  N0622A17F00NM     N0014098G2532  
Friday, May 26, 2017
$0.00
9700: Department of Defense
W81K00: W40M USA HLTH CONTRACTING ACT

B: PURCHASE ORDER
WHOLE FRESH CADAVERS
6510: SURGICAL DRESSING MATERIALS

  W81K0017P0367  
Monday, May 15, 2017
$0.00
7500: Department of Health and Human Services
75N920: NATIONAL INSTITUTES OF HEALTH NHLBI

D: DEFINITIVE CONTRACT
BABY HUG FOLLOW-UP STUDY II
AN12: R&D- MEDICAL: BIOMEDICAL (APPLIED RESEARCH/EXPLORATORY DEVELOPMENT)

  HHSN268201200019C     NHLBIHB1202  
Thursday, May 11, 2017
$3,635.00
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

B: PURCHASE ORDER
DSAEK CORNEA
6515: MEDICAL AND SURGICAL INSTRUMENTS, EQUIPMENT, AND SUPPLIES

  VA25717P1616     VA257-17-Q-0759  
Wednesday, May 10, 2017
$3,635.00
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

B: PURCHASE ORDER
DSAEK CORNEA
6515: MEDICAL AND SURGICAL INSTRUMENTS, EQUIPMENT, AND SUPPLIES

  VA25717P1452     VA257-17-Q-0688  
Wednesday, May 3, 2017
$3,635.00
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

B: PURCHASE ORDER
DSEAK CORNEA
6515: MEDICAL AND SURGICAL INSTRUMENTS, EQUIPMENT, AND SUPPLIES

  VA25717P1536     VA257-17-Q-0725  
Wednesday, May 3, 2017
$80,000.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
OVERALL HYPOTHESIS.. LOW DOSE RADIATION INDUCES MOLECULAR MANIFESTATIONS OF A PRO INFLAMMATORY RESPONSE AS A FUNCTION OF RADIATION TYPE, RADIATION DOSES, DOSES RATES, LET VALUE, AND TIME. AN ORAL AVAILABLE ANTI INFLAMMATORY COUNTERMEASURE, ALREADY IN HUMAN CLINICAL TRIALS WITH A GOOD SAFETY PROFILE, WILL SIGNIFICANTLY REDUCE PROTON AND HZE ION EXPOSURE ASSOCIATED TUMOR INITIATION AND PROGRESSION. ALTHOUGH BIOLOGICAL MECHANISMS OF NORMAL TISSUE RADIATION INJURY ARE NOT COMPLETELY UNDERSTOOD, THE ROLES OF SPECIFIC PATHWAYS IN SOME CELL TYPES ARE BECOMING ELUCIDATED. WHILE CELL DEATH IS GENERALLY BELIEVED TO BE ONE THE MAIN CAUSES OF TISSUE INJURY FROM EXPOSURE TO HIGHER DOSES OF LOW AND HIGH LET RADIATION, THE DOSE AND DOSE RATES LIKELY TO BE ENCOUNTERED BY AN ASTRONAUT ON LONG TERM MISSIONS INTO DEEP SPACE ARE UNLIKELY TO CAUSE MASSIVE CELL DEATH. PATHOLOGICAL MANIFESTATIONS AFTER LOW DOSE SPACE RADIATION SHOULD BE STRONGLY INFLUENCED BY NON CYTOTOXIC RADIATION EFFECTS, RESULTING IN INCREMENTAL SMALL CHANGES IN CELL FUNCTION, IMMUNE (MICRO ENVIRONMENTAL)ALTERED RESPONSES, AND CHANGES IN METABOLISM. TO MORE FULLY UNDERSTAND THE TISSUE EFFECTS OF EXPOSURE TO SPACE RADIATION COMPARED TO BACKGROUND CANCER ON EARTH, IT WILL REQUIRE A MORE INTEGRATED OMICS AND BIOLOGICAL END POINT ANALYSIS AS IS PROPOSED IN THIS FOCUSED PROPOSAL USING AGE APPROPRIATE MOUSE MODELS TO HELP FORM THE BASIS OF A NEW DESCRIPTION OF RADIATION QUALITY EFFECTS AND CANCER RISK. OUR PUBLISHED DATA (CLIN CANCER RESEARCH, 2014) LED US TO THE HYPOTHESIS THAT PROTRACTED FRACTIONATED HIGH LET IRRADIATION CAN HAVE LONG TERM EFFECTS BY CHANGING THE MICROENVIRONMENT IN TISSUES LEADING TO A PRO INFLAMMATORY CANCER PROGRESSING PHENOTYPE. IMPORTANTLY, THE MICROARRAY SIGNATURES IN THESE PUBLISHED STUDIES ON THE K RAS LUNG CANCER SUSCEPTIBLE MOUSE MODEL OF LUNG CANCER WERE SHOWN TO BE APPLICABLE TO OVERALL SURVIVAL IN HUMANS WITH LUNG AND BREAST CANCER. THUS, THE STUDIES PROPOSED ARE LIKELY TO BE APPLICABLE TO HUMAN RISKS. IN THE CURRENT PROPOSAL WE WILL TEST THIS HYPOTHESIS RIGOROUSLY WITH NORMAL MICE, INDUCIBLE EGFR MUTANT MICE SUSCEPTIBLE TO LUNG CANCER AND A COLON CANCER SUSCEPTIBLE MOUSE MODEL (CPC APC) BY INCORPORATING THE COUNTERMEASURE ARM IN ALREADY APPROVED STUDIES. WE HAVE ALREADY ESTABLISHED DOSE RESPONSES FOR TUMOR INCIDENCE IN THE K RAS AND CPC APC MOUSE MODELS USING SI, O, PROTONS AND SPE SIMULATIONS AND PROPOSE TO DEMONSTRATE THAT ORAL DELIVERABLE CDDO (WITH A KNOWN MECHANISM OF ACTION) USING MISSION RELEVANT IRRADIATION DOSES CAN SIGNIFICANTLY DECREASE TUMOR INCIDENCE (EGFR MUTANT MICE WITHOUT INDUCTION OF MUTANT EGFR ARE ESSENTIALLY WT MICE) OR PROGRESSION INVASIVENESS (DOXYCYCLINE INDUCTION OF MUTANT EGFR EITHER BEFORE OR AFTER IRRADIATION). WE WILL FOCUS ON INTERMEDIATE PERSISTENT EFFECTS (14 TO 100 DAYS POST IR) INCLUDING SOME LONG TERM EFFECTS (150 TO 200 DAYS). WE WILL CONDUCT TISSUE MICRO DISSECTIONS AND OMICS ANALYSES OF NORMAL TISSUES, PRECANCEROUS LESIONS, MALIGNANT LESIONS, AND CLEARED MARGINS SURROUNDING THE PRECANCEROUS LESIONS IN MICE WITH AND WITHOUT BEING PROVIDED THE MEDICAL RADIOPROTECTOR, CDDO. WE PROPOSE THAT USING A VARIETY OF RADIATION QUALITIES AND BIOLOGICAL MODELS, WE WILL BE ABLE TO DISSECT THE IMPORTANT DIFFERENCE BETWEEN SPACE RADIATION AND TERRESTRIAL RADIATION. THIS WILL LEAD TO IMPROVED RISK QUANTIFICATION AND DEVELOPMENT OF NEW SYSTEMS BIOLOGY RISK MODELING APPROACHES THAT CAN BE EXTRAPOLATED TO HUMAN CANCER RISKS.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX16AE08G  
Monday, May 1, 2017
$353,760.86
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

D: DEFINITIVE CONTRACT
IGF::OT::IGF ENT (OTOLARYNGOLOGY)
Q514: MEDICAL- OTOLARYNGOLOGY

  VA25717C0023     VA257-17-R-0129  
Wednesday, April 26, 2017
$0.00
9700: Department of Defense
W81K00: W40M USA HLTH CONTRACTING ACT

B: PURCHASE ORDER
CADAVERS
6510: SURGICAL DRESSING MATERIALS

  W81K0017P0368  
Friday, April 21, 2017
$11,480.00
7500: Department of Health and Human Services
75F401: FDA OFFICE OF ACQ GRANT SVCS

B: PURCHASE ORDER
IGF::OT::IGF MICRORNA PROFILING
B504: SPECIAL STUDIES/ANALYSIS- CHEMICAL/BIOLOGICAL

  HHSF223201610332A  
Monday, April 10, 2017
$0.00
7500: Department of Health and Human Services
75F401: FDA OFFICE OF ACQ GRANT SVCS

B: PURCHASE ORDER
IGF::OT::IGF MICRORNA PROFILING
B504: SPECIAL STUDIES/ANALYSIS- CHEMICAL/BIOLOGICAL

  HHSF223201610332A  
Wednesday, April 5, 2017
($19,159.00)
9700: Department of Defense
N0622A: NAVY MEDICINE PROFESSIONAL

C: DELIVERY ORDER
IGF::OT::IGF TUITION AND FEES
U005: EDUCATION/TRAINING- TUITION/REGISTRATION/MEMBERSHIP FEES

  8E29     N0014098G2532  
Friday, March 31, 2017
$499,652.76
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

D: DEFINITIVE CONTRACT
IGF::OT::IGF CARDIOTHORACIC SURGEONS&PERFUSIONISTS
Q502: MEDICAL- CARDIO-VASCULAR

  VA25717C0088     VA257-17-Q-0431  
Thursday, March 30, 2017
$424,999.98
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

B: PURCHASE ORDER
IGF::OT::IGF REFERENCE LAB SERVICES
Q301: MEDICAL- LABORATORY TESTING

  VA25717P1727  
Wednesday, March 29, 2017
$50,000.00
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

D: DEFINITIVE CONTRACT
IGF::OT::IGF VETERINARY SERVICES
R416: SUPPORT- PROFESSIONAL: VETERINARY/ANIMAL CARE

  VA25714C0094     VA257-14-Q-0529  
Monday, March 27, 2017
$20,000.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
THE INTEGRATED CARDIOVASCULAR (ICV) EXPERIMENT WAS PERHAPS THE MOST AMBITIOUS AND COMPREHENSIVE CARDIOVASCULAR STUDY PERFORMED IN THE ISS ERA. ALTHOUGH MANY QUESTIONS REGARDING THE CARDIOVASCULAR ADAPTATION TO LONG DURATION SPACEFLIGHT WERE ANSWERED, A NUMBER OF OTHER KEY QUESTIONS WERE RAISED THAT WE PROPOSE TO ADDRESS IN THIS OMNIBUS APPLICATION. THE FOCUS OF THIS APPLICATION IS WITH THE RISK OF ATRIAL FIBRILLATION (AFIB), THE MOST COMMON CLINICAL ARRHYTHMIA IN THE ASTRONAUT DEMOGRAPHIC. WITH THE AGING OF THE ASTRONAUT POPULATION, NUMEROUS CASES OF AFIB HAVE BEEN OBSERVED, PRIMARILY IN ACTIVE ASTRONAUTS ON THE GROUND. THEREFORE AFIB HAS BECOME AN ISSUE OF INCREASING IMPORTANCE FOR FLIGHT MEDICINE. IN ADDITION, IT MAY BE THAT THE EXTENSIVE EXERCISE PERFORMED ON THE ISS, WHICH PREVENTS CARDIAC ATROPHY AND CV DECONDITIONING, MIGHT ACTUALLY INCREASE THE RISK OF ATRIAL FIBRILLATION AS IT DOES IN COMPETITIVE ATHLETES. BECAUSE OF THE EXTENSIVE CARDIAC STRUCTURAL AND ARRHYTHMIA ANALYSIS ALREADY PERFORMED BY THE ICV INVESTIGATORS, ONLY MINOR MODIFICATIONS TO THE ICV ANALYSIS PLAN WOULD ALLOW HIGH RESOLUTION ASSESSMENT OF AFIB RISK. WE PROPOSE TO ANALYZE OUR ALREADY ACQUIRED DATA TO ASSESS ATRIAL MORPHOLOGY, ELECTROPHYSIOLOGY AND RISK FOR AFIB IN COMPLETED ICV SUBJECTS.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX15AP25G  
Tuesday, February 28, 2017
$0.00
9700: Department of Defense
W81K02: W40M FT LEWIS RHCO PACIFIC

B: PURCHASE ORDER
TEMPORAL BONES
6515: MEDICAL AND SURGICAL INSTRUMENTS, EQUIPMENT, AND SUPPLIES

  W81K0217P0167  
Tuesday, February 28, 2017
$0.00
7500: Department of Health and Human Services
75N920: NATIONAL INSTITUTES OF HEALTH NHLBI

D: DEFINITIVE CONTRACT
BABY HUG FOLLOW-UP STUDY II
AN12: R&D- MEDICAL: BIOMEDICAL (APPLIED RESEARCH/EXPLORATORY DEVELOPMENT)

  HHSN268201200019C     NHLBIHB1202  
Thursday, February 16, 2017
$28,778.04
3600: Department of Veterans Affairs
36C671: 671-SAN ANTONIO (00671)

B: PURCHASE ORDER
IGF::OT::IGF LASER SAFETY OFFICER
J065: MAINT/REPAIR/REBUILD OF EQUIPMENT- MEDICAL, DENTAL, AND VETERINARY EQUIPMENT AND SUPPLIES

  VA25715P2164  
Friday, February 3, 2017
$0.00
9700: Department of Defense
W81K00: W40M USA HLTH CONTRACTING ACT

B: PURCHASE ORDER
OTO TEMPORAL BONE (PAIR) FRESH
6910: TRAINING AIDS

  W81K0017P0178  
Wednesday, February 1, 2017
$141,666.66
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

B: PURCHASE ORDER
IGF::OT::IGF LAB TESTING
Q301: MEDICAL- LABORATORY TESTING

  VA25716P1662  
Wednesday, February 1, 2017
$599,226.32
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

D: DEFINITIVE CONTRACT
IGF::OT::IGF GENERAL/ONCOLOGY/VASCULAR SURGERY SERVICE
Q523: MEDICAL- SURGERY

  VA25717C0024     VA257-17-R-0130  
Wednesday, February 1, 2017
$3,635.00
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

B: PURCHASE ORDER
CORNEA
6515: MEDICAL AND SURGICAL INSTRUMENTS, EQUIPMENT, AND SUPPLIES

  VA25717P0715     VA257-17-Q-0369  
Wednesday, February 1, 2017
$748,879.34
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

D: DEFINITIVE CONTRACT
IGF::OT::IGF NEUROSURGERY
Q510: MEDICAL- NEUROLOGY

  VA25717C0029     VA257-17-R-0143  
Friday, January 20, 2017
$100,000.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
OVERALL HYPOTHESIS.. LOW DOSE RADIATION INDUCES MOLECULAR MANIFESTATIONS OF A PRO INFLAMMATORY RESPONSE AS A FUNCTION OF RADIATION TYPE, RADIATION DOSES, DOSES RATES, LET VALUE, AND TIME. AN ORAL AVAILABLE ANTI INFLAMMATORY COUNTERMEASURE, ALREADY IN HUMAN CLINICAL TRIALS WITH A GOOD SAFETY PROFILE, WILL SIGNIFICANTLY REDUCE PROTON AND HZE ION EXPOSURE ASSOCIATED TUMOR INITIATION AND PROGRESSION. ALTHOUGH BIOLOGICAL MECHANISMS OF NORMAL TISSUE RADIATION INJURY ARE NOT COMPLETELY UNDERSTOOD, THE ROLES OF SPECIFIC PATHWAYS IN SOME CELL TYPES ARE BECOMING ELUCIDATED. WHILE CELL DEATH IS GENERALLY BELIEVED TO BE ONE THE MAIN CAUSES OF TISSUE INJURY FROM EXPOSURE TO HIGHER DOSES OF LOW AND HIGH LET RADIATION, THE DOSE AND DOSE RATES LIKELY TO BE ENCOUNTERED BY AN ASTRONAUT ON LONG TERM MISSIONS INTO DEEP SPACE ARE UNLIKELY TO CAUSE MASSIVE CELL DEATH. PATHOLOGICAL MANIFESTATIONS AFTER LOW DOSE SPACE RADIATION SHOULD BE STRONGLY INFLUENCED BY NON CYTOTOXIC RADIATION EFFECTS, RESULTING IN INCREMENTAL SMALL CHANGES IN CELL FUNCTION, IMMUNE (MICRO ENVIRONMENTAL)ALTERED RESPONSES, AND CHANGES IN METABOLISM. TO MORE FULLY UNDERSTAND THE TISSUE EFFECTS OF EXPOSURE TO SPACE RADIATION COMPARED TO BACKGROUND CANCER ON EARTH, IT WILL REQUIRE A MORE INTEGRATED OMICS AND BIOLOGICAL END POINT ANALYSIS AS IS PROPOSED IN THIS FOCUSED PROPOSAL USING AGE APPROPRIATE MOUSE MODELS TO HELP FORM THE BASIS OF A NEW DESCRIPTION OF RADIATION QUALITY EFFECTS AND CANCER RISK. OUR PUBLISHED DATA (CLIN CANCER RESEARCH, 2014) LED US TO THE HYPOTHESIS THAT PROTRACTED FRACTIONATED HIGH LET IRRADIATION CAN HAVE LONG TERM EFFECTS BY CHANGING THE MICROENVIRONMENT IN TISSUES LEADING TO A PRO INFLAMMATORY CANCER PROGRESSING PHENOTYPE. IMPORTANTLY, THE MICROARRAY SIGNATURES IN THESE PUBLISHED STUDIES ON THE K RAS LUNG CANCER SUSCEPTIBLE MOUSE MODEL OF LUNG CANCER WERE SHOWN TO BE APPLICABLE TO OVERALL SURVIVAL IN HUMANS WITH LUNG AND BREAST CANCER. THUS, THE STUDIES PROPOSED ARE LIKELY TO BE APPLICABLE TO HUMAN RISKS. IN THE CURRENT PROPOSAL WE WILL TEST THIS HYPOTHESIS RIGOROUSLY WITH NORMAL MICE, INDUCIBLE EGFR MUTANT MICE SUSCEPTIBLE TO LUNG CANCER AND A COLON CANCER SUSCEPTIBLE MOUSE MODEL (CPC APC) BY INCORPORATING THE COUNTERMEASURE ARM IN ALREADY APPROVED STUDIES. WE HAVE ALREADY ESTABLISHED DOSE RESPONSES FOR TUMOR INCIDENCE IN THE K RAS AND CPC APC MOUSE MODELS USING SI, O, PROTONS AND SPE SIMULATIONS AND PROPOSE TO DEMONSTRATE THAT ORAL DELIVERABLE CDDO (WITH A KNOWN MECHANISM OF ACTION) USING MISSION RELEVANT IRRADIATION DOSES CAN SIGNIFICANTLY DECREASE TUMOR INCIDENCE (EGFR MUTANT MICE WITHOUT INDUCTION OF MUTANT EGFR ARE ESSENTIALLY WT MICE) OR PROGRESSION INVASIVENESS (DOXYCYCLINE INDUCTION OF MUTANT EGFR EITHER BEFORE OR AFTER IRRADIATION). WE WILL FOCUS ON INTERMEDIATE PERSISTENT EFFECTS (14 TO 100 DAYS POST IR) INCLUDING SOME LONG TERM EFFECTS (150 TO 200 DAYS). WE WILL CONDUCT TISSUE MICRO DISSECTIONS AND OMICS ANALYSES OF NORMAL TISSUES, PRECANCEROUS LESIONS, MALIGNANT LESIONS, AND CLEARED MARGINS SURROUNDING THE PRECANCEROUS LESIONS IN MICE WITH AND WITHOUT BEING PROVIDED THE MEDICAL RADIOPROTECTOR, CDDO. WE PROPOSE THAT USING A VARIETY OF RADIATION QUALITIES AND BIOLOGICAL MODELS, WE WILL BE ABLE TO DISSECT THE IMPORTANT DIFFERENCE BETWEEN SPACE RADIATION AND TERRESTRIAL RADIATION. THIS WILL LEAD TO IMPROVED RISK QUANTIFICATION AND DEVELOPMENT OF NEW SYSTEMS BIOLOGY RISK MODELING APPROACHES THAT CAN BE EXTRAPOLATED TO HUMAN CANCER RISKS.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX16AE08G  
Thursday, January 19, 2017
$0.00
3600: Department of Veterans Affairs
36C24E: SAO EAST (00240E)

B: IDC
IGF::OT::IGF
Q301: MEDICAL- LABORATORY TESTING

  VA24017D0031     VA240-17-Q-0050  
Thursday, January 19, 2017
$48,000.00
3600: Department of Veterans Affairs
36C24E: SAO EAST (00240E)

C: DELIVERY ORDER
IGF::OT::IGF
Q301: MEDICAL- LABORATORY TESTING

  VA24017J0093     VA24017D0031  
Thursday, January 19, 2017
$9,280.00
9700: Department of Defense
W81K00: W40M USA HLTH CONTRACTING ACT

B: PURCHASE ORDER
CADAVER, WHOLE, EMBALMED
6910: TRAINING AIDS

  W81K0017P0136  
Wednesday, January 18, 2017
$0.00
7500: Department of Health and Human Services
75F401: FDA OFFICE OF ACQ GRANT SVCS

B: PURCHASE ORDER
IGF::OT::IGF MIRNA SEQUENCING FOR DILI STUDY- INVOICE PROCESSING SUPPORT
B504: SPECIAL STUDIES/ANALYSIS- CHEMICAL/BIOLOGICAL

  HHSF223201410112A  
Tuesday, January 17, 2017
$22,285.12
1500: Department of Justice
15JA04: U.S. ATTORNEYS OFFICE-FL(S) (USA04)

B: PURCHASE ORDER
IGF::CT::IGF NEURO RADIOLOGIST
R424: SUPPORT- PROFESSIONAL: EXPERT WITNESS

  DJJ17WUSA040054  
Wednesday, January 11, 2017
$0.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
THE RISKS TO ASTRONAUTS FROM EXPOSURE TO SPACE RADIATION HAVE LONG BEEN OF GREAT CONCERN TO NASA. THESE RISKS ARE NOW MORE IMPORTANT WITH THE ADVENT OF LONG-DURATION SPACE MISSIONS, WHICH RAISES THE RISK OF EXPOSURE TO SPACE RADIATION. WHILE THE EFFECT OF SPACE RADIATION ON CANCER AND CORONARY ARTERY DISEASE HAS BEEN STUDIED, LITTLE IS KNOWN ABOUT THE EFFECT OF SPACE RADIATION ON THE HEART MUSCLE, IN PARTICULAR ON THE ABILITY OF THE HEART MUSCLE TO REPLENISH ITSELF. THE ADULT HEART IS INCAPABLE OF REGENERATING ITSELF AFTER INJURY BECAUSE THE VAST MAJORITY OF HEART MUSCLE CELLS CANNOT DIVIDE. NEVERTHELESS, THE ADULT HUMAN HEART SLOWLY REPLENISHES 1-2% OF ITS MUSCLE EVERY YEAR, AND IT IS ESTIMATED THAT IN A HUMAN HEART CLOSE TO 50% OF THE HEART MUSCLE IS RENEWED DURING ITS LIFESPAN. THEREFORE, PREVENTING THE FORMATION OF NEW HEART MUSCLE CELLS COULD RESULT IN A LOSS OF UP TO 50% OF HEART MUSCLE LEADING TO HEART FAILURE. WE RECENTLY DISCOVERED THAT AFTER BIRTH, THE INCREASE IN OXYGEN IN THE ATMOSPHERE RESULTS IN FORMATION OF HARMFUL REACTIVE OXYGEN SPECIES (ROS), WHICH IN TURN DAMAGE THE DNA OF HEART MUSCLE CELLS (CARDIOMYOCYTES) AND CAUSE THEM TO STOP DIVIDING. INTRIGUINGLY, A SMALL POPULATION OF DIVIDING HEART MUSCLE CELLS IS PROTECTED FROM DNA DAMAGE BY MAINTAINING THEMSELVES IN A LOW OXYGEN ENVIRONMENT WITHIN THE HEART. HOWEVER, IF PROLONGED EXPOSURE TO SPACE RADIATION DAMAGES THE DNA OF THESE CELLS, THEN THE HEART WILL LOSE ANY ABILITY TO REPLENISH ITSELF. OUR PROPOSAL WILL DETERMINE THE LONG-TERM EFFECT OF SPACE RADIATION ON THE HEART BY SHUTTING DOWN THE SLOW, BUT CRUCIAL, ABILITY OF THE HEART TO REPLENISH ITSELF. THE LONG-TERM GOAL OF THIS PROJECT IS TO DEVELOP COUNTERMEASURES TO REDUCE HEART FAILURE RISK DUE TO SPACE RADIATION IN ASTRONAUTS.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX15AE06G  
Tuesday, January 3, 2017
$151,497.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
THE RISKS TO ASTRONAUTS FROM EXPOSURE TO SPACE RADIATION HAVE LONG BEEN OF GREAT CONCERN TO NASA. THESE RISKS ARE NOW MORE IMPORTANT WITH THE ADVENT OF LONG-DURATION SPACE MISSIONS, WHICH RAISES THE RISK OF EXPOSURE TO SPACE RADIATION. WHILE THE EFFECT OF SPACE RADIATION ON CANCER AND CORONARY ARTERY DISEASE HAS BEEN STUDIED, LITTLE IS KNOWN ABOUT THE EFFECT OF SPACE RADIATION ON THE HEART MUSCLE, IN PARTICULAR ON THE ABILITY OF THE HEART MUSCLE TO REPLENISH ITSELF. THE ADULT HEART IS INCAPABLE OF REGENERATING ITSELF AFTER INJURY BECAUSE THE VAST MAJORITY OF HEART MUSCLE CELLS CANNOT DIVIDE. NEVERTHELESS, THE ADULT HUMAN HEART SLOWLY REPLENISHES 1-2% OF ITS MUSCLE EVERY YEAR, AND IT IS ESTIMATED THAT IN A HUMAN HEART CLOSE TO 50% OF THE HEART MUSCLE IS RENEWED DURING ITS LIFESPAN. THEREFORE, PREVENTING THE FORMATION OF NEW HEART MUSCLE CELLS COULD RESULT IN A LOSS OF UP TO 50% OF HEART MUSCLE LEADING TO HEART FAILURE. WE RECENTLY DISCOVERED THAT AFTER BIRTH, THE INCREASE IN OXYGEN IN THE ATMOSPHERE RESULTS IN FORMATION OF HARMFUL REACTIVE OXYGEN SPECIES (ROS), WHICH IN TURN DAMAGE THE DNA OF HEART MUSCLE CELLS (CARDIOMYOCYTES) AND CAUSE THEM TO STOP DIVIDING. INTRIGUINGLY, A SMALL POPULATION OF DIVIDING HEART MUSCLE CELLS IS PROTECTED FROM DNA DAMAGE BY MAINTAINING THEMSELVES IN A LOW OXYGEN ENVIRONMENT WITHIN THE HEART. HOWEVER, IF PROLONGED EXPOSURE TO SPACE RADIATION DAMAGES THE DNA OF THESE CELLS, THEN THE HEART WILL LOSE ANY ABILITY TO REPLENISH ITSELF. OUR PROPOSAL WILL DETERMINE THE LONG-TERM EFFECT OF SPACE RADIATION ON THE HEART BY SHUTTING DOWN THE SLOW, BUT CRUCIAL, ABILITY OF THE HEART TO REPLENISH ITSELF. THE LONG-TERM GOAL OF THIS PROJECT IS TO DEVELOP COUNTERMEASURES TO REDUCE HEART FAILURE RISK DUE TO SPACE RADIATION IN ASTRONAUTS.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX15AE06G  
Thursday, December 29, 2016
$3,635.00
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

B: PURCHASE ORDER
CORNEA
6515: MEDICAL AND SURGICAL INSTRUMENTS, EQUIPMENT, AND SUPPLIES

  VA25717P0532     VA257-17-Q-0256  
Wednesday, December 28, 2016
$945,108.98
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

D: DEFINITIVE CONTRACT
IGF::OT::IGF ANESTHESIOLOGY (CARDIOTHORACIC)
Q501: MEDICAL- ANESTHESIOLOGY

  VA25717C0031     VA257-17-R-0146  
Tuesday, December 27, 2016
$499,652.76
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

D: DEFINITIVE CONTRACT
IGF::OT::IGF CARDIOTHORACIC&PERFUSIONIST
Q502: MEDICAL- CARDIO-VASCULAR

  VA25716C0148     VA257-16-R-1591  
Friday, December 23, 2016
$0.00
7500: Department of Health and Human Services
75N920: NATIONAL INSTITUTES OF HEALTH NHLBI

D: DEFINITIVE CONTRACT
BABY HUG FOLLOW-UP STUDY II
AN12: R&D- MEDICAL: BIOMEDICAL (APPLIED RESEARCH/EXPLORATORY DEVELOPMENT)

  HHSN268201200019C     NHLBIHB1202  
Wednesday, December 14, 2016
($7,044.00)
1500: Department of Justice
15JA80: U.S. ATTORNEYS OFFICE-TX(W) (USA80)

B: PURCHASE ORDER
IGF::OT::IGF
R424: SUPPORT- PROFESSIONAL: EXPERT WITNESS

  DJJ16WUSA807040  
Wednesday, December 14, 2016
($24,346.60)
1500: Department of Justice
15JA80: U.S. ATTORNEYS OFFICE-TX(W) (USA80)

B: PURCHASE ORDER
IGF::OT::IGF
R424: SUPPORT- PROFESSIONAL: EXPERT WITNESS

  DJJ16WUSA807057  
Friday, December 2, 2016
$32,966.00
9700: Department of Defense
W81K00: W40M USA HLTH CONTRACTING ACT

B: PURCHASE ORDER
WHOLE BODY CADAVER SPECIMENS
6550: IN VITRO DIAGNOSTIC SUBSTANCES, REAGENTS, TEST KITS AND SETS

  W81K0017P0048     W81K0017T0003  
Thursday, December 1, 2016
$141,666.66
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

B: PURCHASE ORDER
IGF::OT::IGF LAB TESTING
Q301: MEDICAL- LABORATORY TESTING

  VA25716P1662  
Wednesday, November 30, 2016
($52,197.06)
7500: Department of Health and Human Services
75N980: NATIONAL INSTITUTES OF HEALTH OLAO

D: DEFINITIVE CONTRACT
IGF::OT::IGF GENETIC FACTORS IN TASTE PERCEPTION AND TOBACCO USAGE.
Q301: MEDICAL- LABORATORY TESTING

  HHSN263201300011C  
Tuesday, November 15, 2016
$0.00
7500: Department of Health and Human Services
75D301: CDC - PITTSBURG

B: IDC
IGF::OT::IGF FOR OTHER FUNCTIONS SHEPHERD IDIQ 2016 DOMAIN-2 CLAUSE CHANGE
AZ12: R&D- OTHER RESEARCH AND DEVELOPMENT (APPLIED RESEARCH/EXPLORATORY DEVELOPMENT)

  HHSD200201691798I     2016N17729  
Friday, November 4, 2016
$0.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
DNA DAMAGE AND CONSEQUENT MUTATIONS INITIATE THE MULTI-STEP CARCINOGENIC PROCESS. SUBSTANTIAL EVIDENCE INDICATES THAT HIGH CHARGE AND ENERGY [HZE] PARTICLES, COMPONENT OF GALACTIC COSMIC RAYS, INDUCED CLUSTERED DNA DAMAGES ARE DIFFICULT TO REPAIR, AND IN SOME INSTANCES ARE IRREPARABLE; THIS HAS BEEN ASSOCIATED WITH THE INCREASED RELATIVE BIOLOGICAL EFFECTIVENESS OF CHROMOSOMAL ABERRATIONS, MUTAGENESIS, AND CARCINOGENESIS. HOWEVER, IT IS UNCLEAR WHY CLUSTERED LESIONS ARE DIFFICULT TO REPAIR, AND THE MECHANISMS BY WHICH UNREPAIRED CLUSTERED DNA LESIONS TRIGGER CARCINOGENIC EVENTS ARE NOT KNOWN. THE GOALS OF THIS PROPOSED RESEARCH ARE TO UTILIZE OUR UNIQUE CAPABILITY TO QUANTITATIVELY ESTIMATE THE ABILITY OF CELLS TO REPAIR OF CLUSTERED DNA LESIONS IN RESPONSE TO A SPECTRUM OF HZE PARTICLES, AND TO DISSECT THE GENETIC FACTORS THAT MAY POTENTIALLY BE INVOLVED IN THE PROCESSING OF COMPLEX DNA LESIONS. THE SPECIFIC AIMS OF THE PROPOSED RESEARCH ARE TO TEST THE HYPOTHESIS THAT: (1) THE CELLULAR ABILITY TO REPAIR HZE PARTICLES INDUCED CLUSTERED DNA DAMAGE IS MODULATED BY RADIATION QUALITY AND CELL CYCLE STAGES, UTILIZING OUR NEWLY ESTABLISHED IN SITU AND IMAGING TECHNOLOGY; (2) HOMOLOGOUS RECOMBINATION PLAYS A KEY FUNCTION IN FACILITATING THE REPAIR OF DOUBLE-STRAND BREAKS ASSOCIATED WITH CLUSTERED DNA LESIONS, USING KEY HOMOLOGOUS RECOMBINATION FACTORS DEFICIENT CELLS; (3) FANCONI ANEMIA (FA) COMPLEX MAY ORCHESTRATE THE REPAIR OF COMPLEX DSBS INDUCED BY HZE PARTICLES, USING A PANEL OF FA PATHWAY DEFICIENT HUMAN CELLS; AND (4) DNA END-PROCESSING NUCLEASES, SUCH AS WERNER SYNDROME PROTEIN (WRN) AND ARTEMIS, MAY FACILITATE THE PROCESSING OF COMPLEX DNA ENDS GENERATED BY HZE PARTICLES USING HUMAN CELLS THAT ARE EITHER DEFICIENT IN WRN AND ARTEMIS OR EXPRESSING DIFFERENT NUCLEASE MUTANT FORMS OF WRN AND ARTEMIS. UNDERSTANDING THE MECHANISM UNDERLYING THE REPAIR OF DNA DAMAGE INDUCED BY HZE PARTICLES WILL HAVE IMPORTANT IMPLICATIONS FOR ESTIMATING THE RISKS TO ASTRONAUT HEALTH ASSOCIATED WITH GCR EXPOSURES.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX13AD57G  
Friday, October 28, 2016
$100,000.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
THE RISKS TO ASTRONAUTS FROM EXPOSURE TO SPACE RADIATION HAVE LONG BEEN OF GREAT CONCERN TO NASA. THESE RISKS ARE NOW MORE IMPORTANT WITH THE ADVENT OF LONG-DURATION SPACE MISSIONS, WHICH RAISES THE RISK OF EXPOSURE TO SPACE RADIATION. WHILE THE EFFECT OF SPACE RADIATION ON CANCER AND CORONARY ARTERY DISEASE HAS BEEN STUDIED, LITTLE IS KNOWN ABOUT THE EFFECT OF SPACE RADIATION ON THE HEART MUSCLE, IN PARTICULAR ON THE ABILITY OF THE HEART MUSCLE TO REPLENISH ITSELF. THE ADULT HEART IS INCAPABLE OF REGENERATING ITSELF AFTER INJURY BECAUSE THE VAST MAJORITY OF HEART MUSCLE CELLS CANNOT DIVIDE. NEVERTHELESS, THE ADULT HUMAN HEART SLOWLY REPLENISHES 1-2% OF ITS MUSCLE EVERY YEAR, AND IT IS ESTIMATED THAT IN A HUMAN HEART CLOSE TO 50% OF THE HEART MUSCLE IS RENEWED DURING ITS LIFESPAN. THEREFORE, PREVENTING THE FORMATION OF NEW HEART MUSCLE CELLS COULD RESULT IN A LOSS OF UP TO 50% OF HEART MUSCLE LEADING TO HEART FAILURE. WE RECENTLY DISCOVERED THAT AFTER BIRTH, THE INCREASE IN OXYGEN IN THE ATMOSPHERE RESULTS IN FORMATION OF HARMFUL REACTIVE OXYGEN SPECIES (ROS), WHICH IN TURN DAMAGE THE DNA OF HEART MUSCLE CELLS (CARDIOMYOCYTES) AND CAUSE THEM TO STOP DIVIDING. INTRIGUINGLY, A SMALL POPULATION OF DIVIDING HEART MUSCLE CELLS IS PROTECTED FROM DNA DAMAGE BY MAINTAINING THEMSELVES IN A LOW OXYGEN ENVIRONMENT WITHIN THE HEART. HOWEVER, IF PROLONGED EXPOSURE TO SPACE RADIATION DAMAGES THE DNA OF THESE CELLS, THEN THE HEART WILL LOSE ANY ABILITY TO REPLENISH ITSELF. OUR PROPOSAL WILL DETERMINE THE LONG-TERM EFFECT OF SPACE RADIATION ON THE HEART BY SHUTTING DOWN THE SLOW, BUT CRUCIAL, ABILITY OF THE HEART TO REPLENISH ITSELF. THE LONG-TERM GOAL OF THIS PROJECT IS TO DEVELOP COUNTERMEASURES TO REDUCE HEART FAILURE RISK DUE TO SPACE RADIATION IN ASTRONAUTS.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX15AE06G  
Wednesday, October 19, 2016
$0.00
9700: Department of Defense
W81K00: W40M USA HLTH CONTRACTING ACT

B: PURCHASE ORDER
HEAD W/NECK, FRESH CADAVERS
6505: DRUGS AND BIOLOGICALS

  W81K0017P0017  
Saturday, October 1, 2016
$420,997.17
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

D: DEFINITIVE CONTRACT
IGF::OT::IGF PLASTIC SURGERY
Q523: MEDICAL- SURGERY

  VA25717C0026     VA257-17-R-0132  
Saturday, October 1, 2016
$141,666.66
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

B: PURCHASE ORDER
IGF::OT::IGF LAB TESTING
Q301: MEDICAL- LABORATORY TESTING

  VA25716P1662  
Saturday, October 1, 2016
$412,432.19
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

D: DEFINITIVE CONTRACT
IGF::OT::IGF ANESTHESIOLOGY (CRITICAL CARE INTENSIVIST)
Q501: MEDICAL- ANESTHESIOLOGY

  VA25717C0030     VA257-17-R-0145  
Saturday, October 1, 2016
$499,252.87
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

D: DEFINITIVE CONTRACT
IGF::OT::IGF NEUROSURGERY
Q510: MEDICAL- NEUROLOGY

  VA25717C0029     VA257-17-R-0143  
Saturday, October 1, 2016
$499,652.76
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

D: DEFINITIVE CONTRACT
IGF::OT::IGF CARDIOTHORACIC&PERFUSIONIST
Q502: MEDICAL- CARDIO-VASCULAR

  VA25716C0148     VA257-16-R-1591  
Saturday, October 1, 2016
$495,265.20
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

D: DEFINITIVE CONTRACT
IGF::OT::IGF ENT (OTOLARYNGOLOGY)
Q514: MEDICAL- OTOLARYNGOLOGY

  VA25717C0023     VA257-17-R-0129  
Saturday, October 1, 2016
$499,895.63
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

D: DEFINITIVE CONTRACT
IGF::OT::IGF UROLOGY SERVICE
Q525: MEDICAL- UROLOGY

  VA25717C0025     VA257-17-R-0131  
Saturday, October 1, 2016
$499,874.02
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

D: DEFINITIVE CONTRACT
IGF::OT::IGF OPHTHALMOLOGY
Q511: MEDICAL- OPHTHALMOLOGY

  VA25717C0027     VA257-17-R-0133  
Saturday, October 1, 2016
$499,355.27
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

D: DEFINITIVE CONTRACT
IGF::OT::IGF GENERAL/ONCOLOGY/VASCULAR SURGERY SERVICE
Q523: MEDICAL- SURGERY

  VA25717C0024     VA257-17-R-0130  
Saturday, October 1, 2016
$472,704.49
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

D: DEFINITIVE CONTRACT
IGF::OT::IGF ANESTHESIOLOGY (CARDIOTHORACIC)
Q501: MEDICAL- ANESTHESIOLOGY

  VA25717C0031     VA257-17-R-0146  
Saturday, October 1, 2016
$499,647.58
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

D: DEFINITIVE CONTRACT
IGF::OT::IGF ORTHOPEDICS
Q513: MEDICAL- ORTHOPEDIC

  VA25717C0028     VA257-17-R-0142  
Friday, September 23, 2016
$3,000.00
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

C: DELIVERY ORDER
IGF::OT::IGF VET TECH SERVICES
R416: SUPPORT- PROFESSIONAL: VETERINARY/ANIMAL CARE

  VA25716J3248     VA25715D0191  
Wednesday, September 21, 2016
$6,563.82
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

B: PURCHASE ORDER
LIMBS
6515: MEDICAL AND SURGICAL INSTRUMENTS, EQUIPMENT, AND SUPPLIES

  VA25716P3943  
Wednesday, September 14, 2016
$1,000.00
7500: Department of Health and Human Services
75D301: CDC - PITTSBURG

B: IDC
IGF::OT::IGF FOR OTHER FUNCTIONS SHEPHERD IDIQ 2016 DOMAIN-2
AZ12: R&D- OTHER RESEARCH AND DEVELOPMENT (APPLIED RESEARCH/EXPLORATORY DEVELOPMENT)

  HHSD200201691798I     2016N17729  
Tuesday, September 13, 2016
$70,000.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
THE RISKS TO ASTRONAUTS FROM EXPOSURE TO SPACE RADIATION HAVE LONG BEEN OF GREAT CONCERN TO NASA. THESE RISKS ARE NOW MORE IMPORTANT WITH THE ADVENT OF LONG-DURATION SPACE MISSIONS, WHICH RAISES THE RISK OF EXPOSURE TO SPACE RADIATION. WHILE THE EFFECT OF SPACE RADIATION ON CANCER AND CORONARY ARTERY DISEASE HAS BEEN STUDIED, LITTLE IS KNOWN ABOUT THE EFFECT OF SPACE RADIATION ON THE HEART MUSCLE, IN PARTICULAR ON THE ABILITY OF THE HEART MUSCLE TO REPLENISH ITSELF. THE ADULT HEART IS INCAPABLE OF REGENERATING ITSELF AFTER INJURY BECAUSE THE VAST MAJORITY OF HEART MUSCLE CELLS CANNOT DIVIDE. NEVERTHELESS, THE ADULT HUMAN HEART SLOWLY REPLENISHES 1-2% OF ITS MUSCLE EVERY YEAR, AND IT IS ESTIMATED THAT IN A HUMAN HEART CLOSE TO 50% OF THE HEART MUSCLE IS RENEWED DURING ITS LIFESPAN. THEREFORE, PREVENTING THE FORMATION OF NEW HEART MUSCLE CELLS COULD RESULT IN A LOSS OF UP TO 50% OF HEART MUSCLE LEADING TO HEART FAILURE. WE RECENTLY DISCOVERED THAT AFTER BIRTH, THE INCREASE IN OXYGEN IN THE ATMOSPHERE RESULTS IN FORMATION OF HARMFUL REACTIVE OXYGEN SPECIES (ROS), WHICH IN TURN DAMAGE THE DNA OF HEART MUSCLE CELLS (CARDIOMYOCYTES) AND CAUSE THEM TO STOP DIVIDING. INTRIGUINGLY, A SMALL POPULATION OF DIVIDING HEART MUSCLE CELLS IS PROTECTED FROM DNA DAMAGE BY MAINTAINING THEMSELVES IN A LOW OXYGEN ENVIRONMENT WITHIN THE HEART. HOWEVER, IF PROLONGED EXPOSURE TO SPACE RADIATION DAMAGES THE DNA OF THESE CELLS, THEN THE HEART WILL LOSE ANY ABILITY TO REPLENISH ITSELF. OUR PROPOSAL WILL DETERMINE THE LONG-TERM EFFECT OF SPACE RADIATION ON THE HEART BY SHUTTING DOWN THE SLOW, BUT CRUCIAL, ABILITY OF THE HEART TO REPLENISH ITSELF. THE LONG-TERM GOAL OF THIS PROJECT IS TO DEVELOP COUNTERMEASURES TO REDUCE HEART FAILURE RISK DUE TO SPACE RADIATION IN ASTRONAUTS.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX15AE06G  
Wednesday, August 31, 2016
$200,000.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
THE UT SOUTHWESTERN MEDICAL CENTER PROPOSAL FOCUSES ON THE DETERMINATION AND QUANTITATION OF RISK FACTORS FROM KEY GENETIC, EPIGENETIC AND CELLULAR FUNCTIONAL CHANGES IN THE MULTI-STEP PATHOGENESIS OF LUNG CANCER FOLLOWING SPACE RADIATION EXPOSURE IN BOTH HUMAN LUNG EPITHELIAL CELLS IN 2D AND 3D (ORGANOTYPIC) CULTURE AND TRANSGENIC MOUSE MODELS OF LUNG CANCER. THESE ASSESSMENTS ARE DESIGNED TO MEASURE EVENTS OF BOTH RADIATION-INDUCED CANCER PROMOTION (OF ALREADY-INITIATED CELLS) AS WELL AS RADIATION-INDUCED INITIATION (MUTATIONAL AND EPIGENETIC) EVENTS, AND INCLUDE EFFECTS ON STEM CELLS. 3D CULTURE AND ANIMAL MODELS WILL MEASURE RISK FACTORS IN BOTH TISSUE SURROGATES AND IN VIVO LUNG TISSUES. THESE INDIVIDUAL RISK FACTORS CAN THEN BE USED TO DEVELOP HYPOTHESES THAT WILL PERMIT MODELING FOR OVERALL RISK OF DEVELOPING INCREASES IN FATAL LUNG CANCER FROM EXPOSURE TO IRRADIATION THAT ARE LIKELY TO BE EXPERIENCED BY ASTRONAUTS ON DEEP-SPACE MISSIONS. WE SPECIFICALLY ADDRESS RADIATION CARCINOGENESIS GAP 1 (EXPERIMENTAL MODELS OF TUMOR DEVELOPMENT TO BE EXTRAPOLATED TO HUMAN RISK PROJECTIONS); AND GAPS 3-6 (MODELS OF CANCER RISK TO REDUCE UNCERTAINTIES IN RADIATION QUALITY EFFECTS, DOSE-RATE DEPENDENCIES, INDIVIDUAL RADIATION SENSITIVITY INCLUDING GENETIC AND EPIGENETIC FACTORS, AGE AND GENDER). THE NEW DATA FROM THIS RESEARCH WILL BE APPLIED IN ADDRESSING HOW SYSTEM BIOLOGY APPROACHES (GAP 7) CAN BE USED TO INTEGRATE THE RESULTS SO THAT MODELING WILL IMPROVE THE PREDICTION OF THE RISK OF FATAL CANCERS FROM EXPOSURE TO SPACE RADIATION. THIS PROPOSAL HAS 4 PROJECTS: 1. HZE PARTICLE EXPOSURE AND THE RISK FOR HUMAN LUNG CARCINOGENESIS; 2. MOUSE MODELS OF LUNG CANCER AFTER HZE PARTICLE IRRADIATION; 3. ORGANOTYPIC (3D) HUMAN AND MOUSE IN VIVO MODELS OF GENOMIC INSTABILITY FOR HZE PARTICLE INDUCED LUNG CARCINOGENESIS; AND 4. INTEGRATING BIOMARKERS OF LUNG CANCER PATHOGENESIS FOR RISK ASSESSMENT AFTER HZE PARTICLE IRRADIATION. PROJECTS ARE SUPPORTED BY ADMINISTRATIVE AND BIOINFORMATICS, BIOSTATISTICS AND DATABASE CORES.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX11AC54G  
Monday, August 29, 2016
$0.00
7500: Department of Health and Human Services
75N980: NATIONAL INSTITUTES OF HEALTH OLAO

D: DEFINITIVE CONTRACT
IGF::OT::IGF GENETIC FACTORS IN TASTE PERCEPTION AND TOBACCO USAGE.
Q301: MEDICAL- LABORATORY TESTING

  HHSN263201300011C  
Wednesday, August 24, 2016
$125,000.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
OVERALL HYPOTHESIS.. LOW DOSE RADIATION INDUCES MOLECULAR MANIFESTATIONS OF A PRO INFLAMMATORY RESPONSE AS A FUNCTION OF RADIATION TYPE, RADIATION DOSES, DOSES RATES, LET VALUE, AND TIME. AN ORAL AVAILABLE ANTI INFLAMMATORY COUNTERMEASURE, ALREADY IN HUMAN CLINICAL TRIALS WITH A GOOD SAFETY PROFILE, WILL SIGNIFICANTLY REDUCE PROTON AND HZE ION EXPOSURE ASSOCIATED TUMOR INITIATION AND PROGRESSION. ALTHOUGH BIOLOGICAL MECHANISMS OF NORMAL TISSUE RADIATION INJURY ARE NOT COMPLETELY UNDERSTOOD, THE ROLES OF SPECIFIC PATHWAYS IN SOME CELL TYPES ARE BECOMING ELUCIDATED. WHILE CELL DEATH IS GENERALLY BELIEVED TO BE ONE THE MAIN CAUSES OF TISSUE INJURY FROM EXPOSURE TO HIGHER DOSES OF LOW AND HIGH LET RADIATION, THE DOSE AND DOSE RATES LIKELY TO BE ENCOUNTERED BY AN ASTRONAUT ON LONG TERM MISSIONS INTO DEEP SPACE ARE UNLIKELY TO CAUSE MASSIVE CELL DEATH. PATHOLOGICAL MANIFESTATIONS AFTER LOW DOSE SPACE RADIATION SHOULD BE STRONGLY INFLUENCED BY NON CYTOTOXIC RADIATION EFFECTS, RESULTING IN INCREMENTAL SMALL CHANGES IN CELL FUNCTION, IMMUNE (MICRO ENVIRONMENTAL)ALTERED RESPONSES, AND CHANGES IN METABOLISM. TO MORE FULLY UNDERSTAND THE TISSUE EFFECTS OF EXPOSURE TO SPACE RADIATION COMPARED TO BACKGROUND CANCER ON EARTH, IT WILL REQUIRE A MORE INTEGRATED OMICS AND BIOLOGICAL END POINT ANALYSIS AS IS PROPOSED IN THIS FOCUSED PROPOSAL USING AGE APPROPRIATE MOUSE MODELS TO HELP FORM THE BASIS OF A NEW DESCRIPTION OF RADIATION QUALITY EFFECTS AND CANCER RISK. OUR PUBLISHED DATA (CLIN CANCER RESEARCH, 2014) LED US TO THE HYPOTHESIS THAT PROTRACTED FRACTIONATED HIGH LET IRRADIATION CAN HAVE LONG TERM EFFECTS BY CHANGING THE MICROENVIRONMENT IN TISSUES LEADING TO A PRO INFLAMMATORY CANCER PROGRESSING PHENOTYPE. IMPORTANTLY, THE MICROARRAY SIGNATURES IN THESE PUBLISHED STUDIES ON THE K RAS LUNG CANCER SUSCEPTIBLE MOUSE MODEL OF LUNG CANCER WERE SHOWN TO BE APPLICABLE TO OVERALL SURVIVAL IN HUMANS WITH LUNG AND BREAST CANCER. THUS, THE STUDIES PROPOSED ARE LIKELY TO BE APPLICABLE TO HUMAN RISKS. IN THE CURRENT PROPOSAL WE WILL TEST THIS HYPOTHESIS RIGOROUSLY WITH NORMAL MICE, INDUCIBLE EGFR MUTANT MICE SUSCEPTIBLE TO LUNG CANCER AND A COLON CANCER SUSCEPTIBLE MOUSE MODEL (CPC APC) BY INCORPORATING THE COUNTERMEASURE ARM IN ALREADY APPROVED STUDIES. WE HAVE ALREADY ESTABLISHED DOSE RESPONSES FOR TUMOR INCIDENCE IN THE K RAS AND CPC APC MOUSE MODELS USING SI, O, PROTONS AND SPE SIMULATIONS AND PROPOSE TO DEMONSTRATE THAT ORAL DELIVERABLE CDDO (WITH A KNOWN MECHANISM OF ACTION) USING MISSION RELEVANT IRRADIATION DOSES CAN SIGNIFICANTLY DECREASE TUMOR INCIDENCE (EGFR MUTANT MICE WITHOUT INDUCTION OF MUTANT EGFR ARE ESSENTIALLY WT MICE) OR PROGRESSION INVASIVENESS (DOXYCYCLINE INDUCTION OF MUTANT EGFR EITHER BEFORE OR AFTER IRRADIATION). WE WILL FOCUS ON INTERMEDIATE PERSISTENT EFFECTS (14 TO 100 DAYS POST IR) INCLUDING SOME LONG TERM EFFECTS (150 TO 200 DAYS). WE WILL CONDUCT TISSUE MICRO DISSECTIONS AND OMICS ANALYSES OF NORMAL TISSUES, PRECANCEROUS LESIONS, MALIGNANT LESIONS, AND CLEARED MARGINS SURROUNDING THE PRECANCEROUS LESIONS IN MICE WITH AND WITHOUT BEING PROVIDED THE MEDICAL RADIOPROTECTOR, CDDO. WE PROPOSE THAT USING A VARIETY OF RADIATION QUALITIES AND BIOLOGICAL MODELS, WE WILL BE ABLE TO DISSECT THE IMPORTANT DIFFERENCE BETWEEN SPACE RADIATION AND TERRESTRIAL RADIATION. THIS WILL LEAD TO IMPROVED RISK QUANTIFICATION AND DEVELOPMENT OF NEW SYSTEMS BIOLOGY RISK MODELING APPROACHES THAT CAN BE EXTRAPOLATED TO HUMAN CANCER RISKS.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX16AE08G  
Wednesday, August 24, 2016
$150,000.00
8000: National Aeronautics and Space Administration
80NSSC: NASA SHARED SERVICES CENTER

G: GRANT FOR RESEARCH
GALACTIC COSMIC RAYS GCR AND SOLAR PARTICLE EVENTS SPES ARE A MAJOR SOURCE OF CARCINOGENIC RISK FOR ASTRONAUTS ON PROLONGED SPACE MISSIONS. LARGE UNCERTAINTIES EXIST IN THE EXACT ESTIMATION OF CANCER RISKS FROM CHARGED PARTICLES DUE TO THE PAUCITY OF EPIDEMIOLOGICAL DATA IN THIS AREA. FURTHERMORE, A MECHANISTIC UNDERSTANDING OF GENETIC CHANGES UNDERLYING TRANSFORMATION BY PARTICLE RADIATION IS NECESSARY FOR THE DEVELOPMENT OF APPROPRIATE COUNTERMEASURES. THUS, EXPERIMENTAL ANIMAL MODELS THAT CLOSELY MIMIC THE PROCESS OF CARCINOGENESIS IN HUMANS ARE ESSENTIAL FOR ONCOGENIC RISK ASSESSMENT. IN THE COURSE OF OUR CURRENTLY FUNDED 3 YR. NASA PROJECT 2013 2016, WE CHARACTERIZED TWO SENSITIVE AND COMPLEMENTARY MOUSE MODELS THAT CAN BE USED TO ELUCIDATE MOLECULAR MECHANISMS UNDERLYING THE PROCESS OF PARTICLE RADIATION INDUCED GLIOBLASTOMA GBM DEVELOPMENT. GBMS ARE LETHAL BRAIN TUMORS WITH VERY DISMAL PROGNOSIS FOR WHICH RADIATION IS THE ONLY KNOWN RISK FACTOR. GBMS REPRESENT THE THIRD LEADING CAUSE OF CANCERRELATED DEATH AMONG ADULTS AGED 30 50 YEARS THE AVERAGE AGE OF ASTRONAUTS, THE MEAN SURVIVAL AFTER DIAGNOSIS BEING ONLY ABOUT 14 MONTHS. GBM WAS THE FIRST CANCER TO BE ANALYZED BY THE CANCER GENOME ATLAS NETWORK TCGA, AND THE KEY GENETIC ALTERATIONS OCCURRING IN GBM ARE NOW WELL DEFINED. BASED ON THIS INFORMATION, WE UTILIZED TRANSGENIC MICE WITH BRAIN RESTRICTED DELETIONS OF GBM RELEVANT TUMOR SUPPRESSORS IN LOGICAL COMBINATIONS TO ANALYZE THE PROCESS OF CHARGED PARTICLE INDUCED CARCINOGENESIS. WE IDENTIFIED AND CHARACTERIZED TWO COMPLEMENTARY MOUSE GBM MODELS THAT WOULD BE IDEAL FOR STUDYING PARTICLE RADIATION INDUCED CARCINOGENESIS NESTIN CRE INK4AB ARF F F AND NESTIN CRE P53F PTENF. THESE MODELS EXHIBIT A LOW FREQUENCY OF SPONTANEOUS GBMS BUT READILY DEVELOP BRAIN TUMORS AFTER EXPOSURE TO HZE PARTICLES, WHICH RESEMBLE HUMAN HIGH GRADE GLIOMAS IN THEIR GENETIC AND MOLECULAR SIGNATURES. USING THESE MICE, WE HAVE CLEARLY DEMONSTRATED THAT HIGH LINEAR ENERGY TRANSFER LET CHARGED PARTICLES HAVE A GREATER TRANSFORMING POTENTIAL COMPARED TO LOW LET RADIATION, AND HAVE CHARACTERIZED THE MOLECULAR EVENTS UNDERLYING FE IONINDUCED GLIOMAGENESIS IN THESE MODELS THIS WORK SETS THE STAGE FOR QUANTITATIVE STUDIES ON RADIATION QUALITY EFFECTS ON CARCINOGENESIS FOR AN ARRAY OF CHARGED PARTICLES REPRESENTING THE GCR AS PROPOSED IN AIM 1. THESE CHARGED PARTICLES INDUCE COMPLEX DNA DOUBLESTRAND BREAKS DSBS THE ACCURATE REPAIR OF WHICH IS CRITICAL FOR PREVENTING TRANSFORMATION. OUR MODELS WILL ALSO ALLOW US TO DETERMINE WHICH DSB REPAIR PATHWAY REPRESENTS A MAJOR BARRIER TO CHARGED PARTICLE INDUCED GLIOMAGENESIS AS PROPOSED IN AIM 2. THIS INFORMATION WOULD BE FUNDAMENTAL TO THE DEVELOPMENT OF A MECHANISTIC UNDERSTANDING OF CHARGED PARTICLE INDUCED CARCINOGENESIS. WE WILL CROSS THE TRANSGENIC MICE CHARACTERIZED BY US WITH MICE HARBORING BRAIN SPECIFIC ABLATION OF NON HOMOLOGOUS END JOINING NHEJ OR HOMOLOGOUS RECOMBINATION HR REPAIR PATHWAYS NESTIN CRE LIGASE4F F AND NESTIN CRE BRCA2F F THAT WERE ESTABLISHED IN THE LABORATORY OF PROF. PETER MCKINNON COLLABORATOR ON PROJECT. FINALLY, GENOMIC AND BIOINFORMATICS ANALYSES WILL BE USED TO DEFINE GENETIC SIGNATURES UNIQUE TO PARTICLE RADIATION INDUCED GLIOBLASTOMAS AND TO DELINEATE KEY PATHWAYS THAT ARE DE REGULATED DURING HZE INDUCED GLIOMAGENESIS AS PROPOSED IN AIM 3. WE ARE HOPEFUL THAT AN IN DEPTH MECHANISTIC ANALYSIS OF CHARGED PARTICLE INDUCED GLIOMAGENESIS IN THESE VALIDATED MOUSE MODELS WILL HELP US TO MAKE SIGNIFICANT PROGRESS TOWARDS CANCER RISK ASSESSMENTS AND DEVELOPMENT OF PROTECTIVE STRATEGIES FOR CHARGED PARTICLE EXPOSURE.
AR21: R&D- SPACE: SCIENCE/APPLICATIONS (BASIC RESEARCH)

  NNX16AD78G  
Monday, August 22, 2016
$0.00
9700: Department of Defense
H92239: HQ USASOC

B: PURCHASE ORDER
SUPPLY CONTRACT FOR CADAVERS FOR MEDICAL TRAINING AT FORT BLISS, TX.
6515: MEDICAL AND SURGICAL INSTRUMENTS, EQUIPMENT, AND SUPPLIES

  H9223916P0038     H9223916TCADA  
Friday, August 19, 2016
$0.00
3600: Department of Veterans Affairs
36C257: 257-NETWORK CONTRACT OFC 17(00257)

B: IDC
IGF::OT::IGF VET TECH SERVICES
R416: SUPPORT- PROFESSIONAL: VETERINARY/ANIMAL CARE

  VA25715D0191     VA257-15-Q-1234  
Thursday, August 18, 2016
$30,421.98
9700: Department of Defense
H92239: HQ USASOC

B: PURCHASE ORDER
SUPPLY CONTRACT FOR HUMAN CADAVERS FOR MEDICAL TRAINING AT FORT BLISS, TX.
6515: MEDICAL AND SURGICAL INSTRUMENTS, EQUIPMENT, AND SUPPLIES

  H9223916P0038     H9223916TCADA  
Thursday, August 18, 2016
$0.00
9700: Department of Defense
W81K00: W40M USA HLTH CONTRACTING ACT

B: PURCHASE ORDER
WHOLE EMBALMED CADAVER
6510: SURGICAL DRESSING MATERIALS

  W81K0016P0421